In silico docking studies of Yucca gloriosa L. phytoconstituents with TNF-α, IL-6 and IL-13 receptor against Asthma
- Publication Type:
- Journal Article
- Citation:
- Chemical Biology Letters, 2023, 10, (1)
- Issue Date:
- 2023-01-01
Open Access
Copyright Clearance Process
- Recently Added
- In Progress
- Open Access
This item is open access.
Yucca gloriosa L has been comprehensively assessed in vitro and in vivo for its action against asthma Y gloriosa L is a rich source of phenolic compounds such as gloriosaols A E and yuccaols A E which exhibit potent antioxidant activity Gloriosaols A E and yuccaols A E are structurally related to corticosteroids The current study describes the in silico docking of some important anti asthmatic phytoconstituents from the plant Y gloriosa L with molecular targets of asthma Toward the recognition of the binding methods of these pharmacologically dynamic components molecular modelling studies were carried out with target proteins i e interleukin IL 6 1N26 IL 13 3LB6 and TNF 2AZ5 using in silico molecular docking The components demonstrated encouraging binding interactions with the amino acid residues at the active sites of these proteins authenticating their verified efficiency as anti asthmatic agents The current research in addition provides insight into the possible herbal drug receptor interaction and synthetic drug montelukast sodium receptor interaction for the possible management of asthma ScienceIn Publishing ISSN 2347 9825
Please use this identifier to cite or link to this item: