Exploring potential anti-inflammatory effects of medicinal cannabis.

Gurgenci, T; Kijanka, G; Greer, R; Huggett, G; Good, P; Moniruzzaman, M; Hardy, J

Exploring potential anti-inflammatory effects of medicinal cannabis.

Gurgenci, T Kijanka, G Greer, R Huggett, G Good, P

Moniruzzaman, M Hardy, J

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Publisher:: SPRINGER
Publication Type:: Journal Article
Citation:: Support Care Cancer, 2023, 31, (12), pp. 629
Issue Date:: 2023-10-14

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Field	Value	Language
dc.contributor.author	Gurgenci, T
dc.contributor.author	Kijanka, G
dc.contributor.author	Greer, R
dc.contributor.author	Huggett, G
dc.contributor.author	Good, P https://orcid.org/0000-0002-8198-0375
dc.contributor.author	Moniruzzaman, M
dc.contributor.author	Hardy, J
dc.date.accessioned	2024-07-10T00:18:49Z
dc.date.available	2023-09-22
dc.date.available	2024-07-10T00:18:49Z
dc.date.issued	2023-10-14
dc.identifier.citation	Support Care Cancer, 2023, 31, (12), pp. 629
dc.identifier.issn	0941-4355
dc.identifier.issn	1433-7339
dc.identifier.uri	http://hdl.handle.net/10453/179759
dc.description.abstract	PURPOSE: Inflammation is thought to play a key role in malignant disease and may play a significant part in the expression of cancer-related symptoms. Cannabidiol (CBD) is a bioactive compound in cannabis and is reported to have significant anti-inflammatory properties. METHOD: Serial C-reactive protein (CRP) levels were measured in all participants recruited to a randomised controlled trial of CBD versus placebo in patients with symptoms related to advanced cancer. A panel of inflammatory cytokines was measured over time in a subset of these patients. RESULTS: There was no difference between the two arms in the trajectory of CRP or cytokine levels from baseline to day 28. CONCLUSION: We were unable to demonstrate an anti-inflammatory effect of CBD in cancer patients. TRIAL REGISTRATION: ANZCTR 26180001220257, registered 20/07/2018.
dc.format	Electronic
dc.language	eng
dc.publisher	SPRINGER
dc.relation.ispartof	Support Care Cancer
dc.relation.isbasedon	10.1007/s00520-023-08069-8
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences
dc.subject.classification	Oncology & Carcinogenesis
dc.subject.classification	32 Biomedical and clinical sciences
dc.subject.classification	42 Health sciences
dc.subject.classification	52 Psychology
dc.subject.mesh	Humans
dc.subject.mesh	Medical Marijuana
dc.subject.mesh	Cannabidiol
dc.subject.mesh	Cannabis
dc.subject.mesh	Anti-Inflammatory Agents
dc.subject.mesh	Neoplasms
dc.subject.mesh	Humans
dc.subject.mesh	Cannabis
dc.subject.mesh	Neoplasms
dc.subject.mesh	Cannabidiol
dc.subject.mesh	Anti-Inflammatory Agents
dc.subject.mesh	Medical Marijuana
dc.subject.mesh	Humans
dc.subject.mesh	Medical Marijuana
dc.subject.mesh	Cannabidiol
dc.subject.mesh	Cannabis
dc.subject.mesh	Anti-Inflammatory Agents
dc.subject.mesh	Neoplasms
dc.title	Exploring potential anti-inflammatory effects of medicinal cannabis.
dc.type	Journal Article
utslib.citation.volume	31
utslib.location.activity	Germany
utslib.for	11 Medical and Health Sciences
utslib.for	17 Psychology and Cognitive Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-07-10T00:18:40Z
pubs.issue	12
pubs.publication-status	Published online
pubs.volume	31
utslib.citation.issue	12

Abstract:

PURPOSE: Inflammation is thought to play a key role in malignant disease and may play a significant part in the expression of cancer-related symptoms. Cannabidiol (CBD) is a bioactive compound in cannabis and is reported to have significant anti-inflammatory properties. METHOD: Serial C-reactive protein (CRP) levels were measured in all participants recruited to a randomised controlled trial of CBD versus placebo in patients with symptoms related to advanced cancer. A panel of inflammatory cytokines was measured over time in a subset of these patients. RESULTS: There was no difference between the two arms in the trajectory of CRP or cytokine levels from baseline to day 28. CONCLUSION: We were unable to demonstrate an anti-inflammatory effect of CBD in cancer patients. TRIAL REGISTRATION: ANZCTR 26180001220257, registered 20/07/2018.

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http://hdl.handle.net/10453/179759