Novel inductively coupled ear-bars (ICEs) to enhance restored fMRI signal from susceptibility compensation in rats.

Chen, Y; Fernandez, Z; Scheel, N; Gifani, M; Zhu, DC; Counts, SE; Dorrance, AM; Razansky, D; Yu, X; Qian, W; Qian, C

Novel inductively coupled ear-bars (ICEs) to enhance restored fMRI signal from susceptibility compensation in rats.

Chen, Y Fernandez, Z Scheel, N Gifani, M Zhu, DC Counts, SE Dorrance, AM Razansky, D Yu, X

Qian, W Qian, C

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Publisher:: Oxford University Press (OUP)
Publication Type:: Journal Article
Citation:: Cereb Cortex, 2024, 34, (1), pp. bhad479
Issue Date:: 2024-01-14

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Field	Value	Language
dc.contributor.author	Chen, Y
dc.contributor.author	Fernandez, Z
dc.contributor.author	Scheel, N
dc.contributor.author	Gifani, M
dc.contributor.author	Zhu, DC
dc.contributor.author	Counts, SE
dc.contributor.author	Dorrance, AM
dc.contributor.author	Razansky, D
dc.contributor.author	Yu, X https://orcid.org/0000-0002-0269-5649
dc.contributor.author	Qian, W
dc.contributor.author	Qian, C
dc.date.accessioned	2024-08-06T03:55:14Z
dc.date.available	2023-11-21
dc.date.available	2024-08-06T03:55:14Z
dc.date.issued	2024-01-14
dc.identifier.citation	Cereb Cortex, 2024, 34, (1), pp. bhad479
dc.identifier.issn	1047-3211
dc.identifier.issn	1460-2199
dc.identifier.uri	http://hdl.handle.net/10453/180175
dc.description.abstract	Functional magnetic resonance imaging faces inherent challenges when applied to deep-brain areas in rodents, e.g. entorhinal cortex, due to the signal loss near the ear cavities induced by susceptibility artifacts and reduced sensitivity induced by the long distance from the surface array coil. Given the pivotal roles of deep brain regions in various diseases, optimized imaging techniques are needed. To mitigate susceptibility-induced signal losses, we introduced baby cream into the middle ear. To enhance the detection sensitivity of deep brain regions, we implemented inductively coupled ear-bars, resulting in approximately a 2-fold increase in sensitivity in entorhinal cortex. Notably, the inductively coupled ear-bar can be seamlessly integrated as an add-on device, without necessitating modifications to the scanner interface. To underscore the versatility of inductively coupled ear-bars, we conducted echo-planner imaging-based task functional magnetic resonance imaging in rats modeling Alzheimer's disease. As a proof of concept, we also demonstrated resting-state-functional magnetic resonance imaging connectivity maps originating from the left entorhinal cortex-a central hub for memory and navigation networks-to amygdala hippocampal area, Insular Cortex, Prelimbic Systems, Cingulate Cortex, Secondary Visual Cortex, and Motor Cortex. This work demonstrates an optimized procedure for acquiring large-scale networks emanating from a previously challenging seed region by conventional magnetic resonance imaging detectors, thereby facilitating improved observation of functional magnetic resonance imaging outcomes.
dc.format	Print
dc.language	eng
dc.publisher	Oxford University Press (OUP)
dc.relation.ispartof	Cereb Cortex
dc.relation.isbasedon	10.1093/cercor/bhad479
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1109 Neurosciences, 1701 Psychology, 1702 Cognitive Sciences
dc.subject.classification	Experimental Psychology
dc.subject.classification	3209 Neurosciences
dc.subject.classification	5202 Biological psychology
dc.subject.classification	5204 Cognitive and computational psychology
dc.subject.mesh	Rats
dc.subject.mesh	Animals
dc.subject.mesh	Magnetic Resonance Imaging
dc.subject.mesh	Brain Mapping
dc.subject.mesh	Brain
dc.subject.mesh	Gyrus Cinguli
dc.subject.mesh	Alzheimer Disease
dc.subject.mesh	Brain
dc.subject.mesh	Gyrus Cinguli
dc.subject.mesh	Animals
dc.subject.mesh	Rats
dc.subject.mesh	Alzheimer Disease
dc.subject.mesh	Magnetic Resonance Imaging
dc.subject.mesh	Brain Mapping
dc.subject.mesh	Rats
dc.subject.mesh	Animals
dc.subject.mesh	Magnetic Resonance Imaging
dc.subject.mesh	Brain Mapping
dc.subject.mesh	Brain
dc.subject.mesh	Gyrus Cinguli
dc.subject.mesh	Alzheimer Disease
dc.title	Novel inductively coupled ear-bars (ICEs) to enhance restored fMRI signal from susceptibility compensation in rats.
dc.type	Journal Article
utslib.citation.volume	34
utslib.location.activity	United States
utslib.for	1109 Neurosciences
utslib.for	1701 Psychology
utslib.for	1702 Cognitive Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Strength - AAII - Australian Artificial Intelligence Institute
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated	2024-08-06T03:55:11Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	34
utslib.citation.issue	1

Abstract:

Functional magnetic resonance imaging faces inherent challenges when applied to deep-brain areas in rodents, e.g. entorhinal cortex, due to the signal loss near the ear cavities induced by susceptibility artifacts and reduced sensitivity induced by the long distance from the surface array coil. Given the pivotal roles of deep brain regions in various diseases, optimized imaging techniques are needed. To mitigate susceptibility-induced signal losses, we introduced baby cream into the middle ear. To enhance the detection sensitivity of deep brain regions, we implemented inductively coupled ear-bars, resulting in approximately a 2-fold increase in sensitivity in entorhinal cortex. Notably, the inductively coupled ear-bar can be seamlessly integrated as an add-on device, without necessitating modifications to the scanner interface. To underscore the versatility of inductively coupled ear-bars, we conducted echo-planner imaging-based task functional magnetic resonance imaging in rats modeling Alzheimer's disease. As a proof of concept, we also demonstrated resting-state-functional magnetic resonance imaging connectivity maps originating from the left entorhinal cortex-a central hub for memory and navigation networks-to amygdala hippocampal area, Insular Cortex, Prelimbic Systems, Cingulate Cortex, Secondary Visual Cortex, and Motor Cortex. This work demonstrates an optimized procedure for acquiring large-scale networks emanating from a previously challenging seed region by conventional magnetic resonance imaging detectors, thereby facilitating improved observation of functional magnetic resonance imaging outcomes.

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http://hdl.handle.net/10453/180175