Incidence of mother-to-child transmission of HIV and predictors of positivity among HIV exposed infants in South Gondar public hospitals, Northwest Ethiopia: competing risk regression model.

Tilaye, BA; Hailemeskel, HS; Baye, FD; Hailu, MK; Mekonnen, GB; Arage, G; Birhane, BM; Tibebu, NS; Moges, N

Incidence of mother-to-child transmission of HIV and predictors of positivity among HIV exposed infants in South Gondar public hospitals, Northwest Ethiopia: competing risk regression model.

Tilaye, BA Hailemeskel, HS Baye, FD Hailu, MK Mekonnen, GB Arage, G Birhane, BM Tibebu, NS Moges, N

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Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: BMC Pediatr, 2024, 24, (1), pp. 597
Issue Date:: 2024-09-20

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Field	Value	Language
dc.contributor.author	Tilaye, BA
dc.contributor.author	Hailemeskel, HS
dc.contributor.author	Baye, FD
dc.contributor.author	Hailu, MK
dc.contributor.author	Mekonnen, GB
dc.contributor.author	Arage, G
dc.contributor.author	Birhane, BM
dc.contributor.author	Tibebu, NS
dc.contributor.author	Moges, N
dc.date.accessioned	2024-11-19T03:23:23Z
dc.date.available	2024-09-05
dc.date.available	2024-11-19T03:23:23Z
dc.date.issued	2024-09-20
dc.identifier.citation	BMC Pediatr, 2024, 24, (1), pp. 597
dc.identifier.issn	1471-2431
dc.identifier.issn	1471-2431
dc.identifier.uri	http://hdl.handle.net/10453/181978
dc.description.abstract	BACKGROUND: The principal route of HIV infection in children is vertical transmission. Thus, this study aimed to assess the incidence of mother-to-child transmission of HIV and predictors of positivity among HIV-exposed infants. METHOD: Institutions-based retrospective follow-up study was conducted in South Gondar Public hospitals, Northwest Ethiopia from December 2019 to November 2021. The data were taken from PMTCT logbooks and patient medical records, with death being the competing event. Data were entered in to Epi info version 7 and exported to STATA version 14 for final analysis. Both bivariable and multiple variable proportional subdistribution hazard analysis were conducted to identify predictors. P-value < 0.05 was level of significance. RESULT: A total of 469 exposed infant mother pairs records were included. The cumulative incidence rate at the end of the study period was 5.2 per 1000 person months (5.2; 95% CI: 3.4-8.0).Infants' absence of ARV prophylaxis at birth (aSHR = 3.7; 95% CI: 1.33-10.48), Mothers with no PMTCT intervention (aSHR = 5.1; 95% CI: 1.83-14.03), home delivery (aSHR = 4.1; 95%CI: 1.46-11.63) and maternal disclosure of HIV status to partner/families (aSHR = 2.9; 95% CI: 1.06-7.78) were predictors of HIV positivity. CONCLUSION: The study found that Infants' absence of ARV prophylaxis at birth, mothers without PMTCT intervention, home delivery and mothers who were not disclosing their HIV status to families were predictors of HIV positivity.
dc.format	Electronic
dc.language	eng
dc.publisher	Springer Nature
dc.relation.ispartof	BMC Pediatr
dc.relation.isbasedon	10.1186/s12887-024-05061-x
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1114 Paediatrics and Reproductive Medicine
dc.subject.classification	Pediatrics
dc.subject.classification	3213 Paediatrics
dc.subject.classification	4204 Midwifery
dc.subject.mesh	Humans
dc.subject.mesh	Infectious Disease Transmission, Vertical
dc.subject.mesh	Ethiopia
dc.subject.mesh	Female
dc.subject.mesh	HIV Infections
dc.subject.mesh	Incidence
dc.subject.mesh	Retrospective Studies
dc.subject.mesh	Hospitals, Public
dc.subject.mesh	Infant, Newborn
dc.subject.mesh	Infant
dc.subject.mesh	Adult
dc.subject.mesh	Pregnancy
dc.subject.mesh	Male
dc.subject.mesh	Follow-Up Studies
dc.subject.mesh	Pregnancy Complications, Infectious
dc.subject.mesh	Risk Factors
dc.subject.mesh	Young Adult
dc.subject.mesh	Humans
dc.subject.mesh	Pregnancy Complications, Infectious
dc.subject.mesh	HIV Infections
dc.subject.mesh	Incidence
dc.subject.mesh	Risk Factors
dc.subject.mesh	Retrospective Studies
dc.subject.mesh	Follow-Up Studies
dc.subject.mesh	Pregnancy
dc.subject.mesh	Adult
dc.subject.mesh	Infant
dc.subject.mesh	Infant, Newborn
dc.subject.mesh	Hospitals, Public
dc.subject.mesh	Ethiopia
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Infectious Disease Transmission, Vertical
dc.subject.mesh	Young Adult
dc.subject.mesh	Humans
dc.subject.mesh	Infectious Disease Transmission, Vertical
dc.subject.mesh	Ethiopia
dc.subject.mesh	Female
dc.subject.mesh	HIV Infections
dc.subject.mesh	Incidence
dc.subject.mesh	Retrospective Studies
dc.subject.mesh	Hospitals, Public
dc.subject.mesh	Infant, Newborn
dc.subject.mesh	Infant
dc.subject.mesh	Adult
dc.subject.mesh	Pregnancy
dc.subject.mesh	Male
dc.subject.mesh	Follow-Up Studies
dc.subject.mesh	Pregnancy Complications, Infectious
dc.subject.mesh	Risk Factors
dc.subject.mesh	Young Adult
dc.title	Incidence of mother-to-child transmission of HIV and predictors of positivity among HIV exposed infants in South Gondar public hospitals, Northwest Ethiopia: competing risk regression model.
dc.type	Journal Article
utslib.citation.volume	24
utslib.location.activity	England
utslib.for	1114 Paediatrics and Reproductive Medicine
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/School of Public Health
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated	2024-11-19T03:23:21Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	24
utslib.citation.issue	1

Abstract:

BACKGROUND: The principal route of HIV infection in children is vertical transmission. Thus, this study aimed to assess the incidence of mother-to-child transmission of HIV and predictors of positivity among HIV-exposed infants. METHOD: Institutions-based retrospective follow-up study was conducted in South Gondar Public hospitals, Northwest Ethiopia from December 2019 to November 2021. The data were taken from PMTCT logbooks and patient medical records, with death being the competing event. Data were entered in to Epi info version 7 and exported to STATA version 14 for final analysis. Both bivariable and multiple variable proportional subdistribution hazard analysis were conducted to identify predictors. P-value < 0.05 was level of significance. RESULT: A total of 469 exposed infant mother pairs records were included. The cumulative incidence rate at the end of the study period was 5.2 per 1000 person months (5.2; 95% CI: 3.4-8.0).Infants' absence of ARV prophylaxis at birth (aSHR = 3.7; 95% CI: 1.33-10.48), Mothers with no PMTCT intervention (aSHR = 5.1; 95% CI: 1.83-14.03), home delivery (aSHR = 4.1; 95%CI: 1.46-11.63) and maternal disclosure of HIV status to partner/families (aSHR = 2.9; 95% CI: 1.06-7.78) were predictors of HIV positivity. CONCLUSION: The study found that Infants' absence of ARV prophylaxis at birth, mothers without PMTCT intervention, home delivery and mothers who were not disclosing their HIV status to families were predictors of HIV positivity.

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http://hdl.handle.net/10453/181978