Birth Outcomes After Pertussis and Influenza Diagnosed in Pregnancy: A Retrospective, Population-Based Study.

Frawley, JE; He, W-Q; McCallum, L; McIntyre, P; Hayen, A; Gidding, H; Sullivan, E; Liu, B

Birth Outcomes After Pertussis and Influenza Diagnosed in Pregnancy: A Retrospective, Population-Based Study.

Frawley, JE He, W-Q McCallum, L McIntyre, P Hayen, A

Gidding, H Sullivan, E

Liu, B

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: BJOG, 2025, 132, (3), pp. 355-364
Issue Date:: 2025-02

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Field	Value	Language
dc.contributor.author	Frawley, JE
dc.contributor.author	He, W-Q
dc.contributor.author	McCallum, L
dc.contributor.author	McIntyre, P
dc.contributor.author	Hayen, A https://orcid.org/0000-0003-4046-8030
dc.contributor.author	Gidding, H
dc.contributor.author	Sullivan, E https://orcid.org/0000-0002-8718-2753
dc.contributor.author	Liu, B
dc.date.accessioned	2025-01-14T23:46:40Z
dc.date.available	2024-10-01
dc.date.available	2025-01-14T23:46:40Z
dc.date.issued	2025-02
dc.identifier.citation	BJOG, 2025, 132, (3), pp. 355-364
dc.identifier.issn	1470-0328
dc.identifier.issn	1471-0528
dc.identifier.uri	http://hdl.handle.net/10453/183476
dc.description.abstract	OBJECTIVE: Adverse birth outcomes and the maternal severity of influenza in pregnancy are well documented but information on pertussis is limited. DESIGN: Population-based linkage data were collected during 2001-2016. SETTING: New South Wales, Australia. POPULATION OR SAMPLE: A total of 1 453 037 singleton births. METHODS: Cox regression was used to estimate the associations between pertussis or influenza during pregnancy and birth outcomes with adjustment of covariates. MAIN OUTCOME MEASURES: Adverse birth outcomes (preterm birth and low birth weight). RESULTS: Among 1 453 037 singleton births over 16 years, we identified pertussis in 925 (49; 5.3% hospitalised) and influenza in 2850 (1092; 38.3% hospitalised) women during pregnancy. Cases of pertussis were similarly distributed by trimester (32% 3rd) whereas 46% of influenza cases were in the 3rd trimester. Younger age, previous birth, and being overseas-born were associated with both pertussis and influenza, whereas identifying as Aboriginal or Torres Strait Islander, hypertension or diabetes before and during pregnancy, and a number of other factors were only associated with influenza. Both pertussis and influenza in pregnancy were associated with increased risk of preterm birth (pertussis: aHR = 1.30, 95% CI 1.01-1.68; influenza: aHR = 1.56, 95% CI 1.36-1.79) and these increased risks were greater when infections in the period within 2 weeks of birth were considered (pertussis: aHR = 2.36, 95% CI 1.26-4.41; influenza: aHR = 2.29, 95% CI 1.78-2.96). CONCLUSIONS: Maternal pertussis and influenza infections close to the time of birth were associated with adverse birth outcomes. These findings highlight the benefits of vaccination during pregnancy.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY
dc.relation	http://purl.org/au-research/grants/nhmrc/1124075
dc.relation.ispartof	BJOG
dc.relation.isbasedon	10.1111/1471-0528.17984
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	11 Medical and Health Sciences
dc.subject.classification	Obstetrics & Reproductive Medicine
dc.subject.classification	3215 Reproductive medicine
dc.subject.mesh	Humans
dc.subject.mesh	Female
dc.subject.mesh	Pregnancy
dc.subject.mesh	Influenza, Human
dc.subject.mesh	Whooping Cough
dc.subject.mesh	Pregnancy Complications, Infectious
dc.subject.mesh	Adult
dc.subject.mesh	Retrospective Studies
dc.subject.mesh	Premature Birth
dc.subject.mesh	New South Wales
dc.subject.mesh	Infant, Newborn
dc.subject.mesh	Pregnancy Outcome
dc.subject.mesh	Infant, Low Birth Weight
dc.subject.mesh	Young Adult
dc.subject.mesh	Risk Factors
dc.title	Birth Outcomes After Pertussis and Influenza Diagnosed in Pregnancy: A Retrospective, Population-Based Study.
dc.type	Journal Article
utslib.citation.volume	132
utslib.location.activity	England
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/School of Public Health
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Women & Children’s Health Research Collaborative (WCHC)
pubs.organisational-group	University of Technology Sydney/UTS Groups/INSIGHT: Institute for Innovative Solutions for Well-being and Health
utslib.copyright.status	in_progress	*
dc.date.updated	2025-01-14T23:46:39Z
pubs.issue	3
pubs.publication-status	Published
pubs.volume	132
utslib.citation.issue	3

Abstract:

OBJECTIVE: Adverse birth outcomes and the maternal severity of influenza in pregnancy are well documented but information on pertussis is limited. DESIGN: Population-based linkage data were collected during 2001-2016. SETTING: New South Wales, Australia. POPULATION OR SAMPLE: A total of 1 453 037 singleton births. METHODS: Cox regression was used to estimate the associations between pertussis or influenza during pregnancy and birth outcomes with adjustment of covariates. MAIN OUTCOME MEASURES: Adverse birth outcomes (preterm birth and low birth weight). RESULTS: Among 1 453 037 singleton births over 16 years, we identified pertussis in 925 (49; 5.3% hospitalised) and influenza in 2850 (1092; 38.3% hospitalised) women during pregnancy. Cases of pertussis were similarly distributed by trimester (32% 3rd) whereas 46% of influenza cases were in the 3rd trimester. Younger age, previous birth, and being overseas-born were associated with both pertussis and influenza, whereas identifying as Aboriginal or Torres Strait Islander, hypertension or diabetes before and during pregnancy, and a number of other factors were only associated with influenza. Both pertussis and influenza in pregnancy were associated with increased risk of preterm birth (pertussis: aHR = 1.30, 95% CI 1.01-1.68; influenza: aHR = 1.56, 95% CI 1.36-1.79) and these increased risks were greater when infections in the period within 2 weeks of birth were considered (pertussis: aHR = 2.36, 95% CI 1.26-4.41; influenza: aHR = 2.29, 95% CI 1.78-2.96). CONCLUSIONS: Maternal pertussis and influenza infections close to the time of birth were associated with adverse birth outcomes. These findings highlight the benefits of vaccination during pregnancy.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/183476