Effect of a 4-Week Telerehabilitation Program for People With Post-COVID Syndrome on Physical Function and Symptoms: Protocol for a Randomized Controlled Trial.

Reeves, JM; Spencer, LM; Tsai, L-L; Baillie, AJ; Han, Y; Leung, RWM; Bishop, JA; Troy, LK; Corte, TJ; Teoh, AKY; Peters, M; Barton, C; Jones, L; Alison, JA

Effect of a 4-Week Telerehabilitation Program for People With Post-COVID Syndrome on Physical Function and Symptoms: Protocol for a Randomized Controlled Trial.

Reeves, JM Spencer, LM Tsai, L-L Baillie, AJ Han, Y Leung, RWM Bishop, JA Troy, LK Corte, TJ Teoh, AKY Peters, M Barton, C Jones, L Alison, JA

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Publisher:: Oxford University Press (OUP)
Publication Type:: Journal Article
Citation:: Phys Ther, 2024, 104, (9), pp. pzae080
Issue Date:: 2024-09-04

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Field	Value	Language
dc.contributor.author	Reeves, JM
dc.contributor.author	Spencer, LM
dc.contributor.author	Tsai, L-L
dc.contributor.author	Baillie, AJ
dc.contributor.author	Han, Y
dc.contributor.author	Leung, RWM
dc.contributor.author	Bishop, JA
dc.contributor.author	Troy, LK
dc.contributor.author	Corte, TJ
dc.contributor.author	Teoh, AKY
dc.contributor.author	Peters, M
dc.contributor.author	Barton, C
dc.contributor.author	Jones, L
dc.contributor.author	Alison, JA
dc.date.accessioned	2025-01-20T03:12:39Z
dc.date.available	2024-06-27
dc.date.available	2025-01-20T03:12:39Z
dc.date.issued	2024-09-04
dc.identifier.citation	Phys Ther, 2024, 104, (9), pp. pzae080
dc.identifier.issn	0031-9023
dc.identifier.issn	1538-6724
dc.identifier.uri	http://hdl.handle.net/10453/183860
dc.description.abstract	OBJECTIVE: COVID-19 has led to significant morbidity and mortality globally. Post-COVID sequelae can persist beyond the acute and subacute phases of infection, often termed post-COVID syndrome (PCS). There is limited evidence on the appropriate rehabilitation for people with PCS. The aim of this study is to evaluate the effect on exercise capacity, symptoms, cognition, anxiety, depression, health-related quality of life, and fatigue of a 4-week, twice-weekly supervised pulmonary telerehabilitation program compared with usual medical care for people with PCS with persistent respiratory symptoms. METHODS: The study will be a multi-site randomized controlled trial with assessor blinding. Participants with confirmed previous COVID-19 infection and persistent respiratory symptoms who attend a post-COVID respiratory clinic will be randomized 1:1 to either an intervention group of 4 weeks, twice-weekly pulmonary telerehabilitation or a control group of usual medical care. Participants in the control group will be invited to cross-over into the intervention group after the week 4 assessment. Primary outcome: exercise capacity measured by the 1-minute sit-to-stand test. Secondary outcomes: 5 repetition sit-to-stand test; Montreal Cognitive Assessment; COVID-19 Yorkshire Rehabilitation Scale; Chronic Obstructive Pulmonary Disease Assessment Test; 36-Item Short-Form Health Survey; Hospital Anxiety and Depression Scale; Fatigue Severity Scale; and the Kessler Psychological Distress Scale. Outcomes will be collected at baseline, after 4-weeks intervention or control period, after intervention in the cross-over group, and at 12-month follow-up. IMPACT: Research into effective rehabilitation programs is crucial given the substantial morbidity associated with PCS and the lack of long-term data for COVID-19 recovery. A short-duration pulmonary telerehabilitation program, if effective compared with usual care, could inform practice guidelines and direct future clinical trials for the benefit of individuals with persistent respiratory symptoms post-COVID.
dc.format	Print
dc.language	eng
dc.publisher	Oxford University Press (OUP)
dc.relation.ispartof	Phys Ther
dc.relation.isbasedon	10.1093/ptj/pzae080
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1103 Clinical Sciences, 1106 Human Movement and Sports Sciences
dc.subject.classification	Rehabilitation
dc.subject.classification	4201 Allied health and rehabilitation science
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Male
dc.subject.mesh	COVID-19
dc.subject.mesh	Exercise Tolerance
dc.subject.mesh	Post-Acute COVID-19 Syndrome
dc.subject.mesh	Quality of Life
dc.subject.mesh	Randomized Controlled Trials as Topic
dc.subject.mesh	Telerehabilitation
dc.subject.mesh	Multicenter Studies as Topic
dc.subject.mesh	Humans
dc.subject.mesh	Exercise Tolerance
dc.subject.mesh	Quality of Life
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Multicenter Studies as Topic
dc.subject.mesh	Randomized Controlled Trials as Topic
dc.subject.mesh	Telerehabilitation
dc.subject.mesh	COVID-19
dc.subject.mesh	Post-Acute COVID-19 Syndrome
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Male
dc.subject.mesh	COVID-19
dc.subject.mesh	Exercise Tolerance
dc.subject.mesh	Post-Acute COVID-19 Syndrome
dc.subject.mesh	Quality of Life
dc.subject.mesh	Randomized Controlled Trials as Topic
dc.subject.mesh	Telerehabilitation
dc.subject.mesh	Multicenter Studies as Topic
dc.title	Effect of a 4-Week Telerehabilitation Program for People With Post-COVID Syndrome on Physical Function and Symptoms: Protocol for a Randomized Controlled Trial.
dc.type	Journal Article
utslib.citation.volume	104
utslib.location.activity	United States
utslib.for	1103 Clinical Sciences
utslib.for	1106 Human Movement and Sports Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Physiotherapy
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2025-01-20T03:12:38Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	104
utslib.citation.issue	9

Abstract:

OBJECTIVE: COVID-19 has led to significant morbidity and mortality globally. Post-COVID sequelae can persist beyond the acute and subacute phases of infection, often termed post-COVID syndrome (PCS). There is limited evidence on the appropriate rehabilitation for people with PCS. The aim of this study is to evaluate the effect on exercise capacity, symptoms, cognition, anxiety, depression, health-related quality of life, and fatigue of a 4-week, twice-weekly supervised pulmonary telerehabilitation program compared with usual medical care for people with PCS with persistent respiratory symptoms. METHODS: The study will be a multi-site randomized controlled trial with assessor blinding. Participants with confirmed previous COVID-19 infection and persistent respiratory symptoms who attend a post-COVID respiratory clinic will be randomized 1:1 to either an intervention group of 4 weeks, twice-weekly pulmonary telerehabilitation or a control group of usual medical care. Participants in the control group will be invited to cross-over into the intervention group after the week 4 assessment. Primary outcome: exercise capacity measured by the 1-minute sit-to-stand test. Secondary outcomes: 5 repetition sit-to-stand test; Montreal Cognitive Assessment; COVID-19 Yorkshire Rehabilitation Scale; Chronic Obstructive Pulmonary Disease Assessment Test; 36-Item Short-Form Health Survey; Hospital Anxiety and Depression Scale; Fatigue Severity Scale; and the Kessler Psychological Distress Scale. Outcomes will be collected at baseline, after 4-weeks intervention or control period, after intervention in the cross-over group, and at 12-month follow-up. IMPACT: Research into effective rehabilitation programs is crucial given the substantial morbidity associated with PCS and the lack of long-term data for COVID-19 recovery. A short-duration pulmonary telerehabilitation program, if effective compared with usual care, could inform practice guidelines and direct future clinical trials for the benefit of individuals with persistent respiratory symptoms post-COVID.

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http://hdl.handle.net/10453/183860