Nutrient-delivery and metabolism reactivation therapy for melanoma.

Chen, Y; Wang, C; Wu, Y; Wang, Y; Meng, Y; Wu, F; Zhang, H; Cheng, YY; Jiang, X; Shi, J; Li, H; Zhao, P; Wu, J; Zheng, B; Jin, D; Bu, W

Nutrient-delivery and metabolism reactivation therapy for melanoma.

Chen, Y Wang, C Wu, Y Wang, Y Meng, Y Wu, F Zhang, H Cheng, YY Jiang, X Shi, J Li, H Zhao, P Wu, J Zheng, B Jin, D

Bu, W

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Publisher:: NATURE PORTFOLIO
Publication Type:: Journal Article
Citation:: Nat Nanotechnol, 2024, 19, (9), pp. 1399-1408
Issue Date:: 2024-09

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Field	Value	Language
dc.contributor.author	Chen, Y
dc.contributor.author	Wang, C
dc.contributor.author	Wu, Y
dc.contributor.author	Wang, Y
dc.contributor.author	Meng, Y
dc.contributor.author	Wu, F
dc.contributor.author	Zhang, H
dc.contributor.author	Cheng, YY
dc.contributor.author	Jiang, X
dc.contributor.author	Shi, J
dc.contributor.author	Li, H
dc.contributor.author	Zhao, P
dc.contributor.author	Wu, J
dc.contributor.author	Zheng, B
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666
dc.contributor.author	Bu, W
dc.date.accessioned	2025-01-21T06:20:35Z
dc.date.available	2024-05-01
dc.date.available	2025-01-21T06:20:35Z
dc.date.issued	2024-09
dc.identifier.citation	Nat Nanotechnol, 2024, 19, (9), pp. 1399-1408
dc.identifier.issn	1748-3387
dc.identifier.issn	1748-3395
dc.identifier.uri	http://hdl.handle.net/10453/183965
dc.description.abstract	To fulfil the demands of rapid proliferation, tumour cells undergo significant metabolic alterations. Suppression of hyperactivated metabolism has been proven to counteract tumour growth. However, whether the reactivation of downregulated metabolic pathways has therapeutic effects remains unexplored. Here we report a nutrient-based metabolic reactivation strategy for effective melanoma treatment. L-Tyrosine-oleylamine nanomicelles (MTyr-OANPs) were constructed for targeted supplementation of tyrosine to reactivate melanogenesis in melanoma cells. We found that reactivation of melanogenesis using MTyr-OANPs significantly impeded the proliferation of melanoma cells, primarily through the inhibition of glycolysis. Furthermore, leveraging melanin as a natural photothermal reagent for photothermal therapy, we demonstrated the complete eradication of tumours in B16F10 melanoma-bearing mice through treatment with MTyr-OANPs and photothermal therapy. Our strategy for metabolism activation-based tumour treatment suggests specific nutrients as potent activators of metabolic pathways.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	NATURE PORTFOLIO
dc.relation.ispartof	Nat Nanotechnol
dc.relation.isbasedon	10.1038/s41565-024-01690-6
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Nanoscience & Nanotechnology
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Melanoma, Experimental
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Tyrosine
dc.subject.mesh	Melanins
dc.subject.mesh	Cell Proliferation
dc.subject.mesh	Humans
dc.subject.mesh	Micelles
dc.subject.mesh	Melanoma
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Photothermal Therapy
dc.subject.mesh	Glycolysis
dc.subject.mesh	Nutrients
dc.subject.mesh	Mice, Inbred C57BL
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Animals
dc.subject.mesh	Mice, Inbred C57BL
dc.subject.mesh	Humans
dc.subject.mesh	Mice
dc.subject.mesh	Melanoma
dc.subject.mesh	Melanoma, Experimental
dc.subject.mesh	Melanins
dc.subject.mesh	Tyrosine
dc.subject.mesh	Cell Proliferation
dc.subject.mesh	Glycolysis
dc.subject.mesh	Micelles
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Nutrients
dc.subject.mesh	Photothermal Therapy
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Melanoma, Experimental
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Tyrosine
dc.subject.mesh	Melanins
dc.subject.mesh	Cell Proliferation
dc.subject.mesh	Humans
dc.subject.mesh	Micelles
dc.subject.mesh	Melanoma
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Photothermal Therapy
dc.subject.mesh	Glycolysis
dc.subject.mesh	Nutrients
dc.subject.mesh	Mice, Inbred C57BL
dc.title	Nutrient-delivery and metabolism reactivation therapy for melanoma.
dc.type	Journal Article
utslib.citation.volume	19
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Institute of Biomedical Materials and Devices (IBMD)
utslib.copyright.status	open_access	*
dc.date.updated	2025-01-21T06:20:31Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	19
utslib.citation.issue	9

Abstract:

To fulfil the demands of rapid proliferation, tumour cells undergo significant metabolic alterations. Suppression of hyperactivated metabolism has been proven to counteract tumour growth. However, whether the reactivation of downregulated metabolic pathways has therapeutic effects remains unexplored. Here we report a nutrient-based metabolic reactivation strategy for effective melanoma treatment. L-Tyrosine-oleylamine nanomicelles (MTyr-OANPs) were constructed for targeted supplementation of tyrosine to reactivate melanogenesis in melanoma cells. We found that reactivation of melanogenesis using MTyr-OANPs significantly impeded the proliferation of melanoma cells, primarily through the inhibition of glycolysis. Furthermore, leveraging melanin as a natural photothermal reagent for photothermal therapy, we demonstrated the complete eradication of tumours in B16F10 melanoma-bearing mice through treatment with MTyr-OANPs and photothermal therapy. Our strategy for metabolism activation-based tumour treatment suggests specific nutrients as potent activators of metabolic pathways.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/183965