Caffeic acid-grafted chitosan/sodium alginate/nanoclay-based multifunctional 3D-printed hybrid scaffolds for local drug release therapy after breast cancer surgery.

Su, Y; Liu, Y; Hu, X; Lu, Y; Zhang, J; Jin, W; Liu, W; Shu, Y; Cheng, YY; Li, W; Nie, Y; Pan, B; Song, K

Caffeic acid-grafted chitosan/sodium alginate/nanoclay-based multifunctional 3D-printed hybrid scaffolds for local drug release therapy after breast cancer surgery.

Su, Y Liu, Y Hu, X Lu, Y Zhang, J Jin, W Liu, W Shu, Y Cheng, YY Li, W Nie, Y Pan, B Song, K

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Carbohydr Polym, 2024, 324, pp. 121441
Issue Date:: 2024-01-15

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Field	Value	Language
dc.contributor.author	Su, Y
dc.contributor.author	Liu, Y
dc.contributor.author	Hu, X
dc.contributor.author	Lu, Y
dc.contributor.author	Zhang, J
dc.contributor.author	Jin, W
dc.contributor.author	Liu, W
dc.contributor.author	Shu, Y
dc.contributor.author	Cheng, YY
dc.contributor.author	Li, W
dc.contributor.author	Nie, Y
dc.contributor.author	Pan, B
dc.contributor.author	Song, K
dc.date.accessioned	2025-01-21T06:32:50Z
dc.date.available	2023-09-26
dc.date.available	2025-01-21T06:32:50Z
dc.date.issued	2024-01-15
dc.identifier.citation	Carbohydr Polym, 2024, 324, pp. 121441
dc.identifier.issn	0144-8617
dc.identifier.issn	1879-1344
dc.identifier.uri	http://hdl.handle.net/10453/183971
dc.description.abstract	Breast cancer is one of the most common malignant tumors in women all over the world. Mastectomy is the most effective treatment, but there are serious problems such as high tumor recurrence rate and side effects of chemotherapy. Therefore, there is an urgent need for a therapeutic strategy that can effectively promote postoperative wound healing and inhibit local tumor recurrence. In this study, a 3D printing scaffold based on carbon dots-curcumin nano-drug release (CCNPs) was developed as a local drug delivery platform (named CCNACA using CCNPs, Sodium alginate, Nanoclay and Caffeic Acid grafted Chitosan as raw materials), which has the ability to visualize drug release. The 14-day drug release test in vitro showed that the tumor inhibition rate of CCNACA scaffolds on breast cancer cells (MCF-7) was 73.77 ± 1.68 %. And the CCNACA scaffolds had good long-term antibacterial (Escherichia coli and Staphylococcus aureus) activity. Animal experiments have shown that implanting CCNACA scaffolds into surgical defects can inhibit postoperative residual cancer cells, reduce inflammation, promote angiogenesis, and repair tissue defects caused by surgery. In summary, the local drug delivery system of this manuscript has great potential in wound healing and prevention of tumor recurrence after breast cancer surgery.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Carbohydr Polym
dc.relation.isbasedon	10.1016/j.carbpol.2023.121441
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0303 Macromolecular and Materials Chemistry, 0305 Organic Chemistry, 0908 Food Sciences
dc.subject.classification	Polymers
dc.subject.classification	3006 Food sciences
dc.subject.classification	3101 Biochemistry and cell biology
dc.subject.classification	4004 Chemical engineering
dc.subject.mesh	Animals
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Chitosan
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Drug Liberation
dc.subject.mesh	Alginates
dc.subject.mesh	Neoplasm Recurrence, Local
dc.subject.mesh	Mastectomy
dc.subject.mesh	Printing, Three-Dimensional
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Neoplasm Recurrence, Local
dc.subject.mesh	Chitosan
dc.subject.mesh	Alginates
dc.subject.mesh	Mastectomy
dc.subject.mesh	Female
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Drug Liberation
dc.subject.mesh	Printing, Three-Dimensional
dc.subject.mesh	Animals
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Chitosan
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Drug Liberation
dc.subject.mesh	Alginates
dc.subject.mesh	Neoplasm Recurrence, Local
dc.subject.mesh	Mastectomy
dc.subject.mesh	Printing, Three-Dimensional
dc.title	Caffeic acid-grafted chitosan/sodium alginate/nanoclay-based multifunctional 3D-printed hybrid scaffolds for local drug release therapy after breast cancer surgery.
dc.type	Journal Article
utslib.citation.volume	324
utslib.location.activity	England
utslib.for	0303 Macromolecular and Materials Chemistry
utslib.for	0305 Organic Chemistry
utslib.for	0908 Food Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Institute of Biomedical Materials and Devices (IBMD)
utslib.copyright.status	closed_access	*
dc.date.updated	2025-01-21T06:32:45Z
pubs.publication-status	Published
pubs.volume	324

Abstract:

Breast cancer is one of the most common malignant tumors in women all over the world. Mastectomy is the most effective treatment, but there are serious problems such as high tumor recurrence rate and side effects of chemotherapy. Therefore, there is an urgent need for a therapeutic strategy that can effectively promote postoperative wound healing and inhibit local tumor recurrence. In this study, a 3D printing scaffold based on carbon dots-curcumin nano-drug release (CCNPs) was developed as a local drug delivery platform (named CCNACA using CCNPs, Sodium alginate, Nanoclay and Caffeic Acid grafted Chitosan as raw materials), which has the ability to visualize drug release. The 14-day drug release test in vitro showed that the tumor inhibition rate of CCNACA scaffolds on breast cancer cells (MCF-7) was 73.77 ± 1.68 %. And the CCNACA scaffolds had good long-term antibacterial (Escherichia coli and Staphylococcus aureus) activity. Animal experiments have shown that implanting CCNACA scaffolds into surgical defects can inhibit postoperative residual cancer cells, reduce inflammation, promote angiogenesis, and repair tissue defects caused by surgery. In summary, the local drug delivery system of this manuscript has great potential in wound healing and prevention of tumor recurrence after breast cancer surgery.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/183971