Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction.
Siew, K
Nestler, KA
Nelson, C
D'Ambrosio, V
Zhong, C
Li, Z
Grillo, A
Wan, ER
Patel, V
Overbey, E
Kim, J
Blaber, E
Schisler, JC
Eisch, AJ
Muratani, M
Zwart, SR
Smith, SM
Galazka, JM
Mason, CE
Beheshti, A
Walsh, SB
Yun, S
Vaughan, MB
Cheshire, C
Cubitt, L
Broni-Tabi, J
Al-Jaber, MY
Boyko, V
Meydan, C
Barker, P
Arif, S
Afsari, F
Allen, N
Al-Maadheed, M
Altinok, S
Bah, N
Border, S
Brown, AL
Burling, K
Cheng-Campbell, M
Colón, LM
Degoricija, L
Figg, N
Finch, R
Foox, J
Faridi, P
French, A
Gebre, S
Gordon, P
Houerbi, N
Valipour Kahrood, H
Kiffer, FC
Klosinska, AS
Kubik, A
Lee, H-C
Li, Y
Lucarelli, N
Marullo, AL
Matei, I
McCann, CM
Mimar, S
Naglah, A
Nicod, J
O'Shaughnessy, KM
Oliveira, LCD
Oswalt, L
Patras, LI
Lai Polo, S-H
Rodríguez-Lopez, M
Roufosse, C
Sadeghi-Alavijeh, O
Sanchez-Hodge, R
Paul, AS
Schittenhelm, RB
Schweickart, A
Scott, RT
Choy Lim Kam Sian, TC
da Silveira, WA
Slawinski, H
Snell, D
Sosa, J
Saravia-Butler, AM
Tabetah, M
Tanuwidjaya, E
Walker-Samuel, S
Yang, X
Yasmin,
Zhang, H
Godovac-Zimmermann, J
Sarder, P
Sanders, LM
Costes, SV
Campbell, RAA
Karouia, F
Mohamed-Alis, V
Rodriques, S
Lynham, S
Steele, JR
Baranzini, S
Fazelinia, H
Dai, Z
Uruno, A
Shiba, D
Yamamoto, M
A C Almeida, E
- Publisher:
- Springer Nature
- Publication Type:
- Journal Article
- Citation:
- Nat Commun, 2024, 15, (1), pp. 4923
- Issue Date:
- 2024-06-11
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Siew, K | |
dc.contributor.author | Nestler, KA | |
dc.contributor.author | Nelson, C | |
dc.contributor.author | D'Ambrosio, V | |
dc.contributor.author | Zhong, C | |
dc.contributor.author | Li, Z | |
dc.contributor.author | Grillo, A | |
dc.contributor.author | Wan, ER | |
dc.contributor.author | Patel, V | |
dc.contributor.author | Overbey, E | |
dc.contributor.author | Kim, J | |
dc.contributor.author | Blaber, E | |
dc.contributor.author | Schisler, JC | |
dc.contributor.author | Eisch, AJ | |
dc.contributor.author | Muratani, M | |
dc.contributor.author | Zwart, SR | |
dc.contributor.author | Smith, SM | |
dc.contributor.author | Galazka, JM | |
dc.contributor.author | Mason, CE | |
dc.contributor.author | Beheshti, A | |
dc.contributor.author | Walsh, SB | |
dc.contributor.author | Yun, S | |
dc.contributor.author | Vaughan, MB | |
dc.contributor.author | Cheshire, C | |
dc.contributor.author | Cubitt, L | |
dc.contributor.author | Broni-Tabi, J | |
dc.contributor.author | Al-Jaber, MY | |
dc.contributor.author | Boyko, V | |
dc.contributor.author | Meydan, C | |
dc.contributor.author | Barker, P | |
dc.contributor.author | Arif, S | |
dc.contributor.author | Afsari, F | |
dc.contributor.author | Allen, N | |
dc.contributor.author | Al-Maadheed, M | |
dc.contributor.author | Altinok, S | |
dc.contributor.author | Bah, N | |
dc.contributor.author | Border, S | |
dc.contributor.author | Brown, AL | |
dc.contributor.author | Burling, K | |
dc.contributor.author | Cheng-Campbell, M | |
dc.contributor.author | Colón, LM | |
dc.contributor.author | Degoricija, L | |
dc.contributor.author | Figg, N | |
dc.contributor.author | Finch, R | |
dc.contributor.author | Foox, J | |
dc.contributor.author | Faridi, P | |
dc.contributor.author | French, A | |
dc.contributor.author | Gebre, S | |
dc.contributor.author | Gordon, P | |
dc.contributor.author | Houerbi, N | |
dc.contributor.author | Valipour Kahrood, H | |
dc.contributor.author | Kiffer, FC | |
dc.contributor.author | Klosinska, AS | |
dc.contributor.author | Kubik, A | |
dc.contributor.author | Lee, H-C | |
dc.contributor.author | Li, Y | |
dc.contributor.author | Lucarelli, N | |
dc.contributor.author | Marullo, AL | |
dc.contributor.author | Matei, I | |
dc.contributor.author | McCann, CM | |
dc.contributor.author | Mimar, S | |
dc.contributor.author | Naglah, A | |
dc.contributor.author | Nicod, J | |
dc.contributor.author | O'Shaughnessy, KM | |
dc.contributor.author | Oliveira, LCD | |
dc.contributor.author | Oswalt, L | |
dc.contributor.author | Patras, LI | |
dc.contributor.author | Lai Polo, S-H | |
dc.contributor.author | Rodríguez-Lopez, M | |
dc.contributor.author | Roufosse, C | |
dc.contributor.author | Sadeghi-Alavijeh, O | |
dc.contributor.author | Sanchez-Hodge, R | |
dc.contributor.author | Paul, AS | |
dc.contributor.author | Schittenhelm, RB | |
dc.contributor.author | Schweickart, A | |
dc.contributor.author | Scott, RT | |
dc.contributor.author | Choy Lim Kam Sian, TC | |
dc.contributor.author | da Silveira, WA | |
dc.contributor.author | Slawinski, H | |
dc.contributor.author | Snell, D | |
dc.contributor.author | Sosa, J | |
dc.contributor.author | Saravia-Butler, AM | |
dc.contributor.author | Tabetah, M | |
dc.contributor.author | Tanuwidjaya, E | |
dc.contributor.author | Walker-Samuel, S | |
dc.contributor.author | Yang, X | |
dc.contributor.author | Yasmin, | |
dc.contributor.author | Zhang, H | |
dc.contributor.author | Godovac-Zimmermann, J | |
dc.contributor.author | Sarder, P | |
dc.contributor.author | Sanders, LM | |
dc.contributor.author | Costes, SV | |
dc.contributor.author | Campbell, RAA | |
dc.contributor.author | Karouia, F | |
dc.contributor.author | Mohamed-Alis, V | |
dc.contributor.author | Rodriques, S | |
dc.contributor.author | Lynham, S | |
dc.contributor.author | Steele, JR | |
dc.contributor.author | Baranzini, S | |
dc.contributor.author | Fazelinia, H | |
dc.contributor.author | Dai, Z | |
dc.contributor.author | Uruno, A | |
dc.contributor.author | Shiba, D | |
dc.contributor.author | Yamamoto, M | |
dc.contributor.author | A C Almeida, E | |
dc.date.accessioned | 2025-04-08T21:06:42Z | |
dc.date.available | 2024-05-28 | |
dc.date.available | 2025-04-08T21:06:42Z | |
dc.date.issued | 2024-06-11 | |
dc.identifier.citation | Nat Commun, 2024, 15, (1), pp. 4923 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/10453/186797 | |
dc.description.abstract | Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions. We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts' increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | Springer Nature | |
dc.relation.ispartof | Nat Commun | |
dc.relation.isbasedon | 10.1038/s41467-024-49212-1 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Space Flight | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Cosmic Radiation | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Male | |
dc.subject.mesh | Kidney | |
dc.subject.mesh | Kidney Diseases | |
dc.subject.mesh | Weightlessness | |
dc.subject.mesh | Astronauts | |
dc.subject.mesh | Mice, Inbred C57BL | |
dc.subject.mesh | Proteomics | |
dc.subject.mesh | Female | |
dc.subject.mesh | Mars | |
dc.subject.mesh | Weightlessness Simulation | |
dc.subject.mesh | Kidney | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Mice, Inbred C57BL | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Kidney Diseases | |
dc.subject.mesh | Weightlessness Simulation | |
dc.subject.mesh | Proteomics | |
dc.subject.mesh | Cosmic Radiation | |
dc.subject.mesh | Mars | |
dc.subject.mesh | Weightlessness | |
dc.subject.mesh | Space Flight | |
dc.subject.mesh | Astronauts | |
dc.subject.mesh | Female | |
dc.subject.mesh | Male | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Space Flight | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Cosmic Radiation | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Male | |
dc.subject.mesh | Kidney | |
dc.subject.mesh | Kidney Diseases | |
dc.subject.mesh | Weightlessness | |
dc.subject.mesh | Astronauts | |
dc.subject.mesh | Mice, Inbred C57BL | |
dc.subject.mesh | Proteomics | |
dc.subject.mesh | Female | |
dc.subject.mesh | Mars | |
dc.subject.mesh | Weightlessness Simulation | |
dc.title | Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction. | |
dc.type | Journal Article | |
utslib.citation.volume | 15 | |
utslib.location.activity | England | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Provost | |
pubs.organisational-group | University of Technology Sydney/Provost/Jumbunna | |
utslib.copyright.status | open_access | * |
dc.rights.license | This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ | |
dc.date.updated | 2025-04-08T21:06:37Z | |
pubs.issue | 1 | |
pubs.publication-status | Published online | |
pubs.volume | 15 | |
utslib.citation.issue | 1 |
Abstract:
Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions. We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts' increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.
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