Prognostic nutritional index (PNI) is an independent predictor for functional outcome after hip fracture in the elderly: a prospective cohort study.

Chen, Y; Bei, M; Liu, G; Zhang, J; Ge, Y; Tan, Z; Peng, W; Gao, F; Tu, C; Tian, M; Yang, M; Wu, X

Prognostic nutritional index (PNI) is an independent predictor for functional outcome after hip fracture in the elderly: a prospective cohort study.

Chen, Y Bei, M Liu, G Zhang, J Ge, Y Tan, Z Peng, W Gao, F Tu, C Tian, M Yang, M Wu, X

Permalink

Publisher:: SPRINGER LONDON LTD
Publication Type:: Journal Article
Citation:: Arch Osteoporos, 2024, 19, (1), pp. 107
Issue Date:: 2024-11-05

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Published versionAdobe PDF (1.4 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Chen, Y
dc.contributor.author	Bei, M
dc.contributor.author	Liu, G
dc.contributor.author	Zhang, J
dc.contributor.author	Ge, Y
dc.contributor.author	Tan, Z
dc.contributor.author	Peng, W
dc.contributor.author	Gao, F
dc.contributor.author	Tu, C
dc.contributor.author	Tian, M
dc.contributor.author	Yang, M
dc.contributor.author	Wu, X
dc.date.accessioned	2025-04-23T03:12:30Z
dc.date.available	2024-10-21
dc.date.available	2025-04-23T03:12:30Z
dc.date.issued	2024-11-05
dc.identifier.citation	Arch Osteoporos, 2024, 19, (1), pp. 107
dc.identifier.issn	1862-3522
dc.identifier.issn	1862-3514
dc.identifier.uri	http://hdl.handle.net/10453/186969
dc.description.abstract	UNLABELLED: The prognostic nutritional index (PNI) is a useful tool for assessing nutritional status using serum albumin and lymphocyte count. This study indicates that a higher preoperative PNI correlates with improved mobility and health-related quality of life during the initial postoperative period in elderly patients with hip fractures. PURPOSE: To investigate the prognostic value of the prognostic nutritional index (PNI) in predicting mobility and health-related quality of life (HRQoL) in elderly hip fracture patients after surgery. METHODS: We prospectively involved patients aged 65 and above, who could walk freely before injury and underwent surgery between 2018 and 2019. Admission PNI was calculated as serum albumin (g/L) + 5 × total lymphocyte count (× 109/L). Patients were classified into two groups based on PNI median value. All patients were followed up by telephone for four times (30-day, 120-day, 1-year, and 3-year after surgery). The Fracture Mobility Score (FMS) and EuroQol 5-Dimension 5-Level (EQ-5D 5L) were used to evaluate mobility and HRQoL, respectively. RESULTS: Of 705 eligible patients, 487 completed all assessments. Patients in the higher PNI group had a significantly increased possibility of achieving unrestricted mobility at the 120-day follow-up (OR 1.69, 95% CI 1.10-2.61, P.adj = 0.017), while no significant differences were observed at other follow-ups. Additionally, patients in the higher PNI group had a significantly higher EQ-5D utility value at the 30-day follow-up (P.adj = 0.015). A linear regression model with adjusting for all confounders showed that admission PNI value was positively associated with EQ-5D utility values at 30-day, 120-day, and 1-year follow-up assessments (P.adj = 0.011, P.adj = 0.001, and P.adj = 0.030, respectively). However, this correlation was not observed at the 3-year time point (P.adj = 0.079). CONCLUSION: The PNI is a valuable predictor of functional outcomes in elderly patients with hip fractures following surgery.
dc.format	Electronic
dc.language	eng
dc.publisher	SPRINGER LONDON LTD
dc.relation.ispartof	Arch Osteoporos
dc.relation.isbasedon	10.1007/s11657-024-01469-1
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1103 Clinical Sciences, 1104 Complementary and Alternative Medicine
dc.subject.classification	3202 Clinical sciences
dc.subject.mesh	Humans
dc.subject.mesh	Hip Fractures
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Aged
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Prognosis
dc.subject.mesh	Quality of Life
dc.subject.mesh	Nutrition Assessment
dc.subject.mesh	Nutritional Status
dc.subject.mesh	Recovery of Function
dc.subject.mesh	Geriatric Assessment
dc.subject.mesh	Lymphocyte Count
dc.subject.mesh	Humans
dc.subject.mesh	Hip Fractures
dc.subject.mesh	Lymphocyte Count
dc.subject.mesh	Prognosis
dc.subject.mesh	Geriatric Assessment
dc.subject.mesh	Nutrition Assessment
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Recovery of Function
dc.subject.mesh	Nutritional Status
dc.subject.mesh	Quality of Life
dc.subject.mesh	Aged
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Humans
dc.subject.mesh	Hip Fractures
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Aged
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Prognosis
dc.subject.mesh	Quality of Life
dc.subject.mesh	Nutrition Assessment
dc.subject.mesh	Nutritional Status
dc.subject.mesh	Recovery of Function
dc.subject.mesh	Geriatric Assessment
dc.subject.mesh	Lymphocyte Count
dc.title	Prognostic nutritional index (PNI) is an independent predictor for functional outcome after hip fracture in the elderly: a prospective cohort study.
dc.type	Journal Article
utslib.citation.volume	19
utslib.location.activity	England
utslib.for	1103 Clinical Sciences
utslib.for	1104 Complementary and Alternative Medicine
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2025-04-23T03:12:28Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	19
utslib.citation.issue	1

Abstract:

UNLABELLED: The prognostic nutritional index (PNI) is a useful tool for assessing nutritional status using serum albumin and lymphocyte count. This study indicates that a higher preoperative PNI correlates with improved mobility and health-related quality of life during the initial postoperative period in elderly patients with hip fractures. PURPOSE: To investigate the prognostic value of the prognostic nutritional index (PNI) in predicting mobility and health-related quality of life (HRQoL) in elderly hip fracture patients after surgery. METHODS: We prospectively involved patients aged 65 and above, who could walk freely before injury and underwent surgery between 2018 and 2019. Admission PNI was calculated as serum albumin (g/L) + 5 × total lymphocyte count (× 109/L). Patients were classified into two groups based on PNI median value. All patients were followed up by telephone for four times (30-day, 120-day, 1-year, and 3-year after surgery). The Fracture Mobility Score (FMS) and EuroQol 5-Dimension 5-Level (EQ-5D 5L) were used to evaluate mobility and HRQoL, respectively. RESULTS: Of 705 eligible patients, 487 completed all assessments. Patients in the higher PNI group had a significantly increased possibility of achieving unrestricted mobility at the 120-day follow-up (OR 1.69, 95% CI 1.10-2.61, P.adj = 0.017), while no significant differences were observed at other follow-ups. Additionally, patients in the higher PNI group had a significantly higher EQ-5D utility value at the 30-day follow-up (P.adj = 0.015). A linear regression model with adjusting for all confounders showed that admission PNI value was positively associated with EQ-5D utility values at 30-day, 120-day, and 1-year follow-up assessments (P.adj = 0.011, P.adj = 0.001, and P.adj = 0.030, respectively). However, this correlation was not observed at the 3-year time point (P.adj = 0.079). CONCLUSION: The PNI is a valuable predictor of functional outcomes in elderly patients with hip fractures following surgery.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/186969