Global Disparities of Cancer and Its Projected Burden in 2050

Bizuayehu, HM; Ahmed, KY; Kibret, GD; Dadi, AF; Belachew, SA; Bagade, T; Tegegne, TK; Venchiarutti, RL; Kibret, KT; Hailegebireal, AH; Assefa, Y; Khan, N; Abajobir, A; Alene, KA; Mengesha, Z; Erku, D; Enquobahrie, DA

Global Disparities of Cancer and Its Projected Burden in 2050

Bizuayehu, HM Ahmed, KY Kibret, GD Dadi, AF Belachew, SA Bagade, T Tegegne, TK Venchiarutti, RL Kibret, KT Hailegebireal, AH Assefa, Y Khan, N Abajobir, A Alene, KA Mengesha, Z Erku, D Enquobahrie, DA

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Publisher:: American Medical Association (AMA)
Publication Type:: Journal Article
Citation:: JAMA Network Open, 2024, 7, (11), pp. e2443198
Issue Date:: 2024-11-04

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Field	Value	Language
dc.contributor.author	Bizuayehu, HM
dc.contributor.author	Ahmed, KY
dc.contributor.author	Kibret, GD
dc.contributor.author	Dadi, AF
dc.contributor.author	Belachew, SA
dc.contributor.author	Bagade, T
dc.contributor.author	Tegegne, TK
dc.contributor.author	Venchiarutti, RL
dc.contributor.author	Kibret, KT
dc.contributor.author	Hailegebireal, AH
dc.contributor.author	Assefa, Y
dc.contributor.author	Khan, N
dc.contributor.author	Abajobir, A
dc.contributor.author	Alene, KA
dc.contributor.author	Mengesha, Z
dc.contributor.author	Erku, D
dc.contributor.author	Enquobahrie, DA
dc.date.accessioned	2025-04-30T06:29:45Z
dc.date.available	2025-04-30T06:29:45Z
dc.date.issued	2024-11-04
dc.identifier.citation	JAMA Network Open, 2024, 7, (11), pp. e2443198
dc.identifier.issn	2574-3805
dc.identifier.issn	2574-3805
dc.identifier.uri	http://hdl.handle.net/10453/187121
dc.description.abstract	Importance Cancer prevention and care efforts have been challenged by the COVID-19 pandemic and armed conflicts, resulting in a decline in the global Human Development Index (HDI), particularly in low- and middle-income countries. These challenges and subsequent shifts in health care priorities underscore the need to continuously monitor cancer outcome disparities and statistics globally to ensure delivery of equitable and optimal cancer prevention and care in uncertain times. Objective To measure the global burden of 36 cancers in 2022 by sex, age, and geographic location and to project future trends by 2050. Design, Setting, and Participants This cross-sectional study used population-based data from 2022 in 185 countries and territories were obtained from the Global Cancer Observatory database. Data extraction and analysis were carried out in April 2024. Main Outcomes and Measures Counts, rates, prevalence, mortality to incidence ratios (MIRs), and demography-based projections were used to characterize current and future cancer burden. Results This population-based study included 36 cancer types from 185 countries and territories. By 2050, 35.3 million cancer cases worldwide are expected, a 76.6 increase from the 2022 estimate of 20 million. Similarly, 18.5 million cancer deaths are projected by 2050, an 89.7 increase from the 2022 estimate of 9.7 million. Cancer cases and deaths are projected to nearly triple in low-HDI countries by 2050, compared to a moderate increase in very high-HDI countries (142.1 vs 41.7 for cancer cases and 146.1 vs 56.8 for cancer deaths). Males had a higher incidence and greater number of deaths in 2022 than females, with this disparity projected to widen by up to 16.0 in 2050. In 2022, the MIR for all cancers was 46.6 , with higher MIRs observed for pancreatic cancer (89.4 ), among males (51.7 ), among those aged 75 years or older (64.3 ), in low-HDI countries (69.9 ), and in the African region (67.2 ). Conclusions and Relevance In thi
dc.format	Electronic
dc.language	eng
dc.publisher	American Medical Association (AMA)
dc.relation.ispartof	JAMA Network Open
dc.relation.isbasedon	10.1001/jamanetworkopen.2024.43198
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject.classification	32 Biomedical and clinical sciences
dc.subject.classification	42 Health sciences
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Male
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Female
dc.subject.mesh	Global Health
dc.subject.mesh	Middle Aged
dc.subject.mesh	Aged
dc.subject.mesh	Adult
dc.subject.mesh	COVID-19
dc.subject.mesh	Incidence
dc.subject.mesh	Prevalence
dc.subject.mesh	Health Status Disparities
dc.subject.mesh	Young Adult
dc.subject.mesh	Adolescent
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Incidence
dc.subject.mesh	Prevalence
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Adolescent
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Middle Aged
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Health Status Disparities
dc.subject.mesh	Young Adult
dc.subject.mesh	Global Health
dc.subject.mesh	COVID-19
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Male
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Female
dc.subject.mesh	Global Health
dc.subject.mesh	Middle Aged
dc.subject.mesh	Aged
dc.subject.mesh	Adult
dc.subject.mesh	COVID-19
dc.subject.mesh	Incidence
dc.subject.mesh	Prevalence
dc.subject.mesh	Health Status Disparities
dc.subject.mesh	Young Adult
dc.subject.mesh	Adolescent
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	SARS-CoV-2
dc.title	Global Disparities of Cancer and Its Projected Burden in 2050
dc.type	Journal Article
utslib.citation.volume	7
utslib.location.activity	United States
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	recently_added	*
pubs.consider-herdc	true
dc.date.updated	2025-04-30T06:29:43Z
pubs.issue	11
pubs.publication-status	Published
pubs.volume	7
utslib.citation.issue	11

Abstract:

Importance Cancer prevention and care efforts have been challenged by the COVID-19 pandemic and armed conflicts, resulting in a decline in the global Human Development Index (HDI), particularly in low- and middle-income countries. These challenges and subsequent shifts in health care priorities underscore the need to continuously monitor cancer outcome disparities and statistics globally to ensure delivery of equitable and optimal cancer prevention and care in uncertain times. Objective To measure the global burden of 36 cancers in 2022 by sex, age, and geographic location and to project future trends by 2050. Design, Setting, and Participants This cross-sectional study used population-based data from 2022 in 185 countries and territories were obtained from the Global Cancer Observatory database. Data extraction and analysis were carried out in April 2024. Main Outcomes and Measures Counts, rates, prevalence, mortality to incidence ratios (MIRs), and demography-based projections were used to characterize current and future cancer burden. Results This population-based study included 36 cancer types from 185 countries and territories. By 2050, 35.3 million cancer cases worldwide are expected, a 76.6 increase from the 2022 estimate of 20 million. Similarly, 18.5 million cancer deaths are projected by 2050, an 89.7 increase from the 2022 estimate of 9.7 million. Cancer cases and deaths are projected to nearly triple in low-HDI countries by 2050, compared to a moderate increase in very high-HDI countries (142.1 vs 41.7 for cancer cases and 146.1 vs 56.8 for cancer deaths). Males had a higher incidence and greater number of deaths in 2022 than females, with this disparity projected to widen by up to 16.0 in 2050. In 2022, the MIR for all cancers was 46.6 , with higher MIRs observed for pancreatic cancer (89.4 ), among males (51.7 ), among those aged 75 years or older (64.3 ), in low-HDI countries (69.9 ), and in the African region (67.2 ). Conclusions and Relevance In thi

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http://hdl.handle.net/10453/187121