Synbiotics as a Nutraceutical Adjuvant: Neuroprotective and Neurorestorative Effects
- Publisher:
- Springer Nature
- Publication Type:
- Chapter
- Citation:
- Synbiotics in Human Health Biology to Drug Delivery, 2024, pp. 377-392
- Issue Date:
- 2024-01-01
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With the potential to have a synergistic effect on gut microbiota and overall health, synbiotics are dietary supplements that include prebiotics mixed with probiotics to enhance the survival and proliferation of probiotics in the gastrointestinal tract. By enhancing gut microbiota, these combined supplements may improve gut permeability and endothelial function, as well as minimize the production and action of endotoxins and proinflammatory cytokines. The gut-brain axis comprises interactions or “cross talk” among the GI tract, enteric nervous system (ENS), central nervous system (CNS), and gut bacteria. Due to the production of endotoxins and proinflammatory cytokines, the gut-brain axis may then be “negatively regulated,” leading to various central nervous system (CNS) pathologies. Such dysregulation has been explored as a contributing factor to the pathologies of Parkinson’s. The inclusion of synbiotics in the diet supports the survival, growth, and function of the gut microbiota. These ingredients can be found in a variety of foods, including dairy products, fermented vegetables and fruit, and nutritional meals in addition to medicaments. They may also be prepared by conventional isolation or synthetic methods. Based on the evidence that is currently available, this chapter provides an overview of the established neuroprotective effects of probiotics, prebiotics, and synbiotics.
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