Synbiotics as a Nutraceutical Adjuvant: Neuroprotective and Neurorestorative Effects

Nadar, RM; Liu, K; Pathak, S; Deruiter, J; Ramapuram, JB; Lynn, G; Carl, B; Dua, K; Moore, T; Dhanasekaran, M

Synbiotics as a Nutraceutical Adjuvant: Neuroprotective and Neurorestorative Effects

Nadar, RM Liu, K Pathak, S Deruiter, J Ramapuram, JB Lynn, G Carl, B Dua, K

Moore, T Dhanasekaran, M

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Publisher:: Springer Nature
Publication Type:: Chapter
Citation:: Synbiotics in Human Health Biology to Drug Delivery, 2024, pp. 377-392
Issue Date:: 2024-01-01

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Field	Value	Language
dc.contributor.author	Nadar, RM
dc.contributor.author	Liu, K
dc.contributor.author	Pathak, S
dc.contributor.author	Deruiter, J
dc.contributor.author	Ramapuram, JB
dc.contributor.author	Lynn, G
dc.contributor.author	Carl, B
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Moore, T
dc.contributor.author	Dhanasekaran, M
dc.date.accessioned	2025-07-01T05:14:20Z
dc.date.available	2025-07-01T05:14:20Z
dc.date.issued	2024-01-01
dc.identifier.citation	Synbiotics in Human Health Biology to Drug Delivery, 2024, pp. 377-392
dc.identifier.isbn	9789819955749
dc.identifier.uri	http://hdl.handle.net/10453/188023
dc.description.abstract	With the potential to have a synergistic effect on gut microbiota and overall health, synbiotics are dietary supplements that include prebiotics mixed with probiotics to enhance the survival and proliferation of probiotics in the gastrointestinal tract. By enhancing gut microbiota, these combined supplements may improve gut permeability and endothelial function, as well as minimize the production and action of endotoxins and proinflammatory cytokines. The gut-brain axis comprises interactions or “cross talk” among the GI tract, enteric nervous system (ENS), central nervous system (CNS), and gut bacteria. Due to the production of endotoxins and proinflammatory cytokines, the gut-brain axis may then be “negatively regulated,” leading to various central nervous system (CNS) pathologies. Such dysregulation has been explored as a contributing factor to the pathologies of Parkinson’s. The inclusion of synbiotics in the diet supports the survival, growth, and function of the gut microbiota. These ingredients can be found in a variety of foods, including dairy products, fermented vegetables and fruit, and nutritional meals in addition to medicaments. They may also be prepared by conventional isolation or synthetic methods. Based on the evidence that is currently available, this chapter provides an overview of the established neuroprotective effects of probiotics, prebiotics, and synbiotics.
dc.language	en
dc.publisher	Springer Nature
dc.relation.ispartof	Synbiotics in Human Health Biology to Drug Delivery
dc.relation.isbasedon	10.1007/978-981-99-5575-6_18
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	Synbiotics as a Nutraceutical Adjuvant: Neuroprotective and Neurorestorative Effects
dc.type	Chapter
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Inflammation (CFI)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Inflammation (CFI)/Centre for Inflammation (CFI) Associate Members
pubs.organisational-group	University of Technology Sydney/UTS Groups/Australian Research Consortium in Complementary and Integrative Medicine (ARCCIM)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Stroke Research Collaborative
utslib.copyright.status	closed_access	*
dc.date.updated	2025-07-01T05:14:18Z
pubs.publication-status	Published

Abstract:

With the potential to have a synergistic effect on gut microbiota and overall health, synbiotics are dietary supplements that include prebiotics mixed with probiotics to enhance the survival and proliferation of probiotics in the gastrointestinal tract. By enhancing gut microbiota, these combined supplements may improve gut permeability and endothelial function, as well as minimize the production and action of endotoxins and proinflammatory cytokines. The gut-brain axis comprises interactions or “cross talk” among the GI tract, enteric nervous system (ENS), central nervous system (CNS), and gut bacteria. Due to the production of endotoxins and proinflammatory cytokines, the gut-brain axis may then be “negatively regulated,” leading to various central nervous system (CNS) pathologies. Such dysregulation has been explored as a contributing factor to the pathologies of Parkinson’s. The inclusion of synbiotics in the diet supports the survival, growth, and function of the gut microbiota. These ingredients can be found in a variety of foods, including dairy products, fermented vegetables and fruit, and nutritional meals in addition to medicaments. They may also be prepared by conventional isolation or synthetic methods. Based on the evidence that is currently available, this chapter provides an overview of the established neuroprotective effects of probiotics, prebiotics, and synbiotics.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/188023