Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice.

Allam, VSRR; Akula, S; Waern, I; Taha, S; Wernersson, S; Pejler, G

Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice.

Allam, VSRR Akula, S Waern, I Taha, S Wernersson, S Pejler, G

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Publisher:: Springer
Publication Type:: Journal Article
Citation:: Inflammation, 2025, 48, (2), pp. 806-819
Issue Date:: 2025-07-03

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Field	Value	Language
dc.contributor.author	Allam, VSRR
dc.contributor.author	Akula, S
dc.contributor.author	Waern, I
dc.contributor.author	Taha, S
dc.contributor.author	Wernersson, S
dc.contributor.author	Pejler, G
dc.date.accessioned	2025-07-15T06:02:09Z
dc.date.available	2024-06-25
dc.date.available	2025-07-15T06:02:09Z
dc.date.issued	2025-07-03
dc.identifier.citation	Inflammation, 2025, 48, (2), pp. 806-819
dc.identifier.issn	0360-3997
dc.identifier.issn	1573-2576
dc.identifier.uri	http://hdl.handle.net/10453/188316
dc.description.abstract	Despite intense efforts to develop efficient therapeutic regimes for asthma, there is a large demand for novel treatment strategies in this disease. Here we evaluated the impact of monensin, a drug with potent anti-mast cell effects, in a mouse model of asthma. Allergic airway inflammation was induced by sensitization of mice with house dust mite (HDM) antigen, and effects of monensin on airway hyperreactivity and inflammatory parameters were studied. Following intraperitoneal administration, monensin did not suppress airway hyperreactivity but was shown to have anti-inflammatory properties, as manifested by reduced eosinophil- and lymphocyte infiltration into the airway lumen, and by suppressed inflammation of the lung tissue. After intranasal instillation, monensin exhibited similar anti-inflammatory effects as seen after intraperitoneal administration. Moreover, intranasally administered monensin was demonstrated to suppress goblet cell hyperplasia, and to cause a reduction in the expression of genes coding for key inflammatory markers. Further, monensin blocked mast cell degranulation in the airways of allergen-sensitized mice. Together, this study reveals that monensin has the capacity to suppress key pathological events associated with allergic airway inflammation.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer
dc.relation.ispartof	Inflammation
dc.relation.isbasedon	10.1007/s10753-024-02090-7
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1107 Immunology
dc.subject.classification	Immunology
dc.subject.classification	3204 Immunology
dc.subject.mesh	Animals
dc.subject.mesh	Asthma
dc.subject.mesh	Mice
dc.subject.mesh	Pyroglyphidae
dc.subject.mesh	Monensin
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Mast Cells
dc.subject.mesh	Mice, Inbred BALB C
dc.subject.mesh	Anti-Inflammatory Agents
dc.subject.mesh	Lung
dc.subject.mesh	Cell Degranulation
dc.subject.mesh	Lung
dc.subject.mesh	Mast Cells
dc.subject.mesh	Animals
dc.subject.mesh	Mice, Inbred BALB C
dc.subject.mesh	Mice
dc.subject.mesh	Pyroglyphidae
dc.subject.mesh	Asthma
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Monensin
dc.subject.mesh	Anti-Inflammatory Agents
dc.subject.mesh	Cell Degranulation
dc.subject.mesh	Animals
dc.subject.mesh	Asthma
dc.subject.mesh	Mice
dc.subject.mesh	Pyroglyphidae
dc.subject.mesh	Monensin
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Mast Cells
dc.subject.mesh	Mice, Inbred BALB C
dc.subject.mesh	Anti-Inflammatory Agents
dc.subject.mesh	Lung
dc.subject.mesh	Cell Degranulation
dc.title	Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice.
dc.type	Journal Article
utslib.citation.volume	48
utslib.location.activity	United States
utslib.for	1107 Immunology
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2025-07-15T06:01:56Z
pubs.issue	2
pubs.publication-status	Published online
pubs.volume	48
utslib.citation.issue	2

Abstract:

Despite intense efforts to develop efficient therapeutic regimes for asthma, there is a large demand for novel treatment strategies in this disease. Here we evaluated the impact of monensin, a drug with potent anti-mast cell effects, in a mouse model of asthma. Allergic airway inflammation was induced by sensitization of mice with house dust mite (HDM) antigen, and effects of monensin on airway hyperreactivity and inflammatory parameters were studied. Following intraperitoneal administration, monensin did not suppress airway hyperreactivity but was shown to have anti-inflammatory properties, as manifested by reduced eosinophil- and lymphocyte infiltration into the airway lumen, and by suppressed inflammation of the lung tissue. After intranasal instillation, monensin exhibited similar anti-inflammatory effects as seen after intraperitoneal administration. Moreover, intranasally administered monensin was demonstrated to suppress goblet cell hyperplasia, and to cause a reduction in the expression of genes coding for key inflammatory markers. Further, monensin blocked mast cell degranulation in the airways of allergen-sensitized mice. Together, this study reveals that monensin has the capacity to suppress key pathological events associated with allergic airway inflammation.

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http://hdl.handle.net/10453/188316