The use of genetic testing in amyotrophic lateral sclerosis (ALS): a practical approach.

Chaouch, A; Crook, A; Douglas, AGL; McDermott, CJ; Al-Chalabi, A; McNeill, A; Bedford, J; Howard, J; MacLeod, R

The use of genetic testing in amyotrophic lateral sclerosis (ALS): a practical approach.

Chaouch, A Crook, A

Douglas, AGL McDermott, CJ Al-Chalabi, A McNeill, A Bedford, J Howard, J MacLeod, R

Permalink

Publisher:: TAYLOR & FRANCIS LTD
Publication Type:: Journal Article
Citation:: Amyotroph Lateral Scler Frontotemporal Degener, 2025, ahead-of-print, (ahead-of-print), pp. 1-7
Issue Date:: 2025-08-08

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Published versionAdobe PDF (1.4 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Chaouch, A
dc.contributor.author	Crook, A https://orcid.org/0000-0001-5578-0460
dc.contributor.author	Douglas, AGL
dc.contributor.author	McDermott, CJ
dc.contributor.author	Al-Chalabi, A
dc.contributor.author	McNeill, A
dc.contributor.author	Bedford, J
dc.contributor.author	Howard, J
dc.contributor.author	MacLeod, R
dc.date.accessioned	2025-09-03T07:50:45Z
dc.date.available	2025-09-03T07:50:45Z
dc.date.issued	2025-08-08
dc.identifier.citation	Amyotroph Lateral Scler Frontotemporal Degener, 2025, ahead-of-print, (ahead-of-print), pp. 1-7
dc.identifier.issn	2167-8421
dc.identifier.issn	2167-9223
dc.identifier.uri	http://hdl.handle.net/10453/189600
dc.description.abstract	Amyotrophic lateral sclerosis (ALS) is a rare and fatal neurodegenerative disease thought to be precipitated by genetic, environment and lifestyle factors. In the UK, whole genome sequencing has become available to all people living with ALS, regardless of their family history or age of onset of disease. However, there is currently no formal guidance on how to deliver genetic counseling and testing in busy mainstream clinics. This article offers practical suggestions to clinicians who may wish or need to discuss genomic testing. As more clinical trials and targeted gene therapies develop, it is likely that conversations will evolve, reflecting the dynamic nature of this important and complex field.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	TAYLOR & FRANCIS LTD
dc.relation.ispartof	Amyotroph Lateral Scler Frontotemporal Degener
dc.relation.isbasedon	10.1080/21678421.2025.2539895
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1103 Clinical Sciences, 1109 Neurosciences
dc.subject.classification	3209 Neurosciences
dc.title	The use of genetic testing in amyotrophic lateral sclerosis (ALS): a practical approach.
dc.type	Journal Article
utslib.citation.volume	ahead-of-print
utslib.location.activity	England
utslib.for	1103 Clinical Sciences
utslib.for	1109 Neurosciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated	2025-09-03T07:50:43Z
pubs.issue	ahead-of-print
pubs.publication-status	Published online
pubs.volume	ahead-of-print
utslib.citation.issue	ahead-of-print

Abstract:

Amyotrophic lateral sclerosis (ALS) is a rare and fatal neurodegenerative disease thought to be precipitated by genetic, environment and lifestyle factors. In the UK, whole genome sequencing has become available to all people living with ALS, regardless of their family history or age of onset of disease. However, there is currently no formal guidance on how to deliver genetic counseling and testing in busy mainstream clinics. This article offers practical suggestions to clinicians who may wish or need to discuss genomic testing. As more clinical trials and targeted gene therapies develop, it is likely that conversations will evolve, reflecting the dynamic nature of this important and complex field.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/189600