Improving acquisition times of elemental bio-imaging for quadrupole-based LA-ICP-MS

Lear, J; Hare, D; Adlard, P; Finkelstein, D; Doble, P

Improving acquisition times of elemental bio-imaging for quadrupole-based LA-ICP-MS

Lear, J Hare, D

Adlard, P Finkelstein, D Doble, P

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Publication Type:: Journal Article
Citation:: Journal of Analytical Atomic Spectrometry, 2012, 27 (1), pp. 159 - 164
Issue Date:: 2012-01-01

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Field	Value	Language
dc.contributor.author	Lear, J	en_US
dc.contributor.author	Hare, D https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Adlard, P	en_US
dc.contributor.author	Finkelstein, D	en_US
dc.contributor.author	Doble, P https://orcid.org/0000-0002-8472-1301	en_US
dc.date.issued	2012-01-01	en_US
dc.identifier.citation	Journal of Analytical Atomic Spectrometry, 2012, 27 (1), pp. 159 - 164	en_US
dc.identifier.issn	0267-9477	en_US
dc.identifier.uri	http://hdl.handle.net/10453/22046
dc.description.abstract	Elemental bio-imaging experiments by quadrupole-based LA-ICP-MS normally employ scan speeds where the distance traversed in one second is equal to or less than the diameter of the laser beam. Consequently, data for a higher-resolution (pixel size = 15 μm 2) image of a 5 mm 2 tissue section can take upwards of 30 h to acquire. Appropriate laser scan speeds may be calculated by consideration of the relationship between laser scan speed, laser spot diameter and the total scan cycle of the quadrupole mass analyser. This paper presents a simple method to calculate the laser scan speeds capable of reducing the acquisition time by up to a factor of 5 whilst maintaining dimensional integrity of the image. © 2012 The Royal Society of Chemistry.	en_US
dc.relation.ispartof	Journal of Analytical Atomic Spectrometry	en_US
dc.relation.isbasedon	10.1039/c1ja10301f	en_US
dc.subject.classification	Analytical Chemistry	en_US
dc.title	Improving acquisition times of elemental bio-imaging for quadrupole-based LA-ICP-MS	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	27	en_US
utslib.for	0306 Physical Chemistry (incl. Structural)	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	0403 Geology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	27	en_US

Abstract:

Elemental bio-imaging experiments by quadrupole-based LA-ICP-MS normally employ scan speeds where the distance traversed in one second is equal to or less than the diameter of the laser beam. Consequently, data for a higher-resolution (pixel size = 15 μm 2) image of a 5 mm 2 tissue section can take upwards of 30 h to acquire. Appropriate laser scan speeds may be calculated by consideration of the relationship between laser scan speed, laser spot diameter and the total scan cycle of the quadrupole mass analyser. This paper presents a simple method to calculate the laser scan speeds capable of reducing the acquisition time by up to a factor of 5 whilst maintaining dimensional integrity of the image. © 2012 The Royal Society of Chemistry.

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http://hdl.handle.net/10453/22046