Structure of self-organized multilayer nanoparticles for drug delivery

Gerelli, Y; Barbieri, S; Di Bari, MT; Deriu, A; Cantù, L; Brocca, P; Sonvico, F; Colombo, P; May, R; Motta, S

Structure of self-organized multilayer nanoparticles for drug delivery

Gerelli, Y Barbieri, S Di Bari, MT Deriu, A Cantù, L Brocca, P Sonvico, F

Colombo, P May, R Motta, S

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Publication Type:: Journal Article
Citation:: Langmuir, 2008, 24 (20), pp. 11378 - 11384
Issue Date:: 2008-10-21

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Field	Value	Language
dc.contributor.author	Gerelli, Y	en_US
dc.contributor.author	Barbieri, S	en_US
dc.contributor.author	Di Bari, MT	en_US
dc.contributor.author	Deriu, A	en_US
dc.contributor.author	Cantù, L	en_US
dc.contributor.author	Brocca, P	en_US
dc.contributor.author	Sonvico, F https://orcid.org/0000-0001-7372-1456	en_US
dc.contributor.author	Colombo, P	en_US
dc.contributor.author	May, R	en_US
dc.contributor.author	Motta, S	en_US
dc.date.issued	2008-10-21	en_US
dc.identifier.citation	Langmuir, 2008, 24 (20), pp. 11378 - 11384	en_US
dc.identifier.issn	0743-7463	en_US
dc.identifier.uri	http://hdl.handle.net/10453/22066
dc.description.abstract	The combined use of cryo-TEM, dynamic light scattering, and small-angle X-ray and neutron scattering techniques allows a detailed structural model of complex pharmaceutical preparations of soybean lecithin/chitosan nanoparticles used as drug vectors to be worked out. Charge-driven self-organization of the lipid(-)/polysaccharide(+) vesicles occurs during rapid injection, under mechanical stirring, of an ethanol solution of soybean lecithin into a chitosan aqueous solution. We conclude that beyond the charge inversion region of the phase diagram, i.e., entering the redissolution region, the initial stages of particle formation are likely to be affected by a re-entrant condensation effect at the nanoscale. This behavior resembles that at the mesoscale which is well-known for polyion/amphiphile systems. Close to the boundary of the charge inversion region, nanoparticle formation occurs under a maximum condensation condition at the nanoscale and the complexation-aggregation process is driven toward a maximum multilamellarity. Interestingly, the formulation that maximizes vesicle multilamellarity corresponds to that displaying the highest drug loading efficiency. © 2008 American Chemical Society.	en_US
dc.relation.ispartof	Langmuir	en_US
dc.relation.isbasedon	10.1021/la801992t	en_US
dc.subject.classification	Chemical Physics	en_US
dc.subject.mesh	Ions	en_US
dc.subject.mesh	Chitosan	en_US
dc.subject.mesh	Liposomes	en_US
dc.subject.mesh	Drug Carriers	en_US
dc.subject.mesh	Cryoelectron Microscopy	en_US
dc.subject.mesh	Microscopy, Electron, Transmission	en_US
dc.subject.mesh	Drug Delivery Systems	en_US
dc.subject.mesh	Lasers	en_US
dc.subject.mesh	Particle Size	en_US
dc.subject.mesh	Surface Properties	en_US
dc.subject.mesh	Neutrons	en_US
dc.subject.mesh	Light	en_US
dc.subject.mesh	X-Rays	en_US
dc.subject.mesh	Scattering, Radiation	en_US
dc.subject.mesh	Nanoparticles	en_US
dc.title	Structure of self-organized multilayer nanoparticles for drug delivery	en_US
dc.type	Journal Article
utslib.citation.volume	20	en_US
utslib.citation.volume	24	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.issue	20	en_US
pubs.publication-status	Published	en_US
pubs.volume	24	en_US

Abstract:

The combined use of cryo-TEM, dynamic light scattering, and small-angle X-ray and neutron scattering techniques allows a detailed structural model of complex pharmaceutical preparations of soybean lecithin/chitosan nanoparticles used as drug vectors to be worked out. Charge-driven self-organization of the lipid(-)/polysaccharide(+) vesicles occurs during rapid injection, under mechanical stirring, of an ethanol solution of soybean lecithin into a chitosan aqueous solution. We conclude that beyond the charge inversion region of the phase diagram, i.e., entering the redissolution region, the initial stages of particle formation are likely to be affected by a re-entrant condensation effect at the nanoscale. This behavior resembles that at the mesoscale which is well-known for polyion/amphiphile systems. Close to the boundary of the charge inversion region, nanoparticle formation occurs under a maximum condensation condition at the nanoscale and the complexation-aggregation process is driven toward a maximum multilamellarity. Interestingly, the formulation that maximizes vesicle multilamellarity corresponds to that displaying the highest drug loading efficiency. © 2008 American Chemical Society.

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http://hdl.handle.net/10453/22066