Predictors of cord blood IgE levels in children at risk for asthma and atopy

Scirica, CV; Gold, DR; Ryan, L; Abulkerim, H; Celedón, JC; Platts-Mills, TAE; Naccara, LM; Weiss, ST; Litonjua, AA

Predictors of cord blood IgE levels in children at risk for asthma and atopy

Scirica, CV Gold, DR Ryan, L

Abulkerim, H Celedón, JC Platts-Mills, TAE Naccara, LM Weiss, ST Litonjua, AA

Permalink

Publication Type:: Journal Article
Citation:: Journal of Allergy and Clinical Immunology, 2007, 119 (1), pp. 81 - 88
Issue Date:: 2007-01-01

Closed Access

	Filename	Description	Size
	2011008534OK.pdf		137.07 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Scirica, CV	en_US
dc.contributor.author	Gold, DR	en_US
dc.contributor.author	Ryan, L https://orcid.org/0000-0001-5957-2490	en_US
dc.contributor.author	Abulkerim, H	en_US
dc.contributor.author	Celedón, JC	en_US
dc.contributor.author	Platts-Mills, TAE	en_US
dc.contributor.author	Naccara, LM	en_US
dc.contributor.author	Weiss, ST	en_US
dc.contributor.author	Litonjua, AA	en_US
dc.date.available	2006-09-01	en_US
dc.date.issued	2007-01-01	en_US
dc.identifier.citation	Journal of Allergy and Clinical Immunology, 2007, 119 (1), pp. 81 - 88	en_US
dc.identifier.issn	0091-6749	en_US
dc.identifier.uri	http://hdl.handle.net/10453/26014
dc.description.abstract	Background: Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels. Objective: Our objective was to identify predictors of cord blood IgE levels among infants at increased risk of atopy. Methods: Cord blood IgE levels were measured in 874 infants who were screened for participation in a birth cohort. Questionnaires were administered after birth of the infant, and maternal and cord blood was obtained for measurement of IgE levels. Logistic and tobit regression models were used to study the association between perinatal factors and cord blood IgE levels. Results: In multivariable models infant male sex, increased maternal total IgE level, maternal allergen sensitization, Hispanic ethnicity, and residence in low-income areas were associated with detectable or increased cord blood IgE levels, whereas increasing maternal age was associated with undetectable or lower cord blood IgE levels. Although maternal smoking during pregnancy was positively associated with cord blood IgE levels in univariable models, the effect did not persist after adjusting for potential confounders. Conclusion: Maternal allergen sensitization, markers of socioeconomic disadvantage and race/ethnicity, maternal age, and infant sex might influence fetal production of IgE. We found no association of maternal parity, mode of delivery, gestational age, or season of birth with cord blood IgE levels. Clinical implications: The identification of these definable familial and environmental factors that predict cord blood IgE levels might help in the early detection of infants at risk for atopic disorders. © 2007 American Academy of Allergy, Asthma & Immunology.	en_US
dc.relation.ispartof	Journal of Allergy and Clinical Immunology	en_US
dc.relation.isbasedon	10.1016/j.jaci.2006.09.002	en_US
dc.subject.classification	Allergy	en_US
dc.subject.mesh	Fetal Blood	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Asthma	en_US
dc.subject.mesh	Hypersensitivity, Immediate	en_US
dc.subject.mesh	Immunoglobulin E	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Cohort Studies	en_US
dc.subject.mesh	Maternal Age	en_US
dc.subject.mesh	Sex Factors	en_US
dc.subject.mesh	Poverty	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Infant, Newborn	en_US
dc.subject.mesh	Hispanic Americans	en_US
dc.subject.mesh	Boston	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Predictors of cord blood IgE levels in children at risk for asthma and atopy	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	119	en_US
utslib.for	010402 Biostatistics	en_US
utslib.for	1107 Immunology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	119	en_US

Abstract:

Background: Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels. Objective: Our objective was to identify predictors of cord blood IgE levels among infants at increased risk of atopy. Methods: Cord blood IgE levels were measured in 874 infants who were screened for participation in a birth cohort. Questionnaires were administered after birth of the infant, and maternal and cord blood was obtained for measurement of IgE levels. Logistic and tobit regression models were used to study the association between perinatal factors and cord blood IgE levels. Results: In multivariable models infant male sex, increased maternal total IgE level, maternal allergen sensitization, Hispanic ethnicity, and residence in low-income areas were associated with detectable or increased cord blood IgE levels, whereas increasing maternal age was associated with undetectable or lower cord blood IgE levels. Although maternal smoking during pregnancy was positively associated with cord blood IgE levels in univariable models, the effect did not persist after adjusting for potential confounders. Conclusion: Maternal allergen sensitization, markers of socioeconomic disadvantage and race/ethnicity, maternal age, and infant sex might influence fetal production of IgE. We found no association of maternal parity, mode of delivery, gestational age, or season of birth with cord blood IgE levels. Clinical implications: The identification of these definable familial and environmental factors that predict cord blood IgE levels might help in the early detection of infants at risk for atopic disorders. © 2007 American Academy of Allergy, Asthma & Immunology.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/26014