Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-γ

Gold, DR; Willwerth, BM; Tantisira, KG; Finn, PW; Schaub, B; Perkins, DL; Tzianabos, A; Ly, NP; Schroeter, C; Gibbons, F; Campos, H; Oken, E; Gillman, MW; Palmer, LJ; Ryan, LM; Weiss, ST

Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-γ

Gold, DR Willwerth, BM Tantisira, KG Finn, PW Schaub, B Perkins, DL Tzianabos, A Ly, NP Schroeter, C Gibbons, F Campos, H Oken, E Gillman, MW Palmer, LJ Ryan, LM

Weiss, ST

Permalink

Publication Type:: Journal Article
Citation:: Journal of Allergy and Clinical Immunology, 2006, 117 (4), pp. 931 - 938
Issue Date:: 2006-04-01

Closed Access

	Filename	Description	Size
	2011008538OK.pdf		173.69 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Gold, DR	en_US
dc.contributor.author	Willwerth, BM	en_US
dc.contributor.author	Tantisira, KG	en_US
dc.contributor.author	Finn, PW	en_US
dc.contributor.author	Schaub, B	en_US
dc.contributor.author	Perkins, DL	en_US
dc.contributor.author	Tzianabos, A	en_US
dc.contributor.author	Ly, NP	en_US
dc.contributor.author	Schroeter, C	en_US
dc.contributor.author	Gibbons, F	en_US
dc.contributor.author	Campos, H	en_US
dc.contributor.author	Oken, E	en_US
dc.contributor.author	Gillman, MW	en_US
dc.contributor.author	Palmer, LJ	en_US
dc.contributor.author	Ryan, LM https://orcid.org/0000-0001-5957-2490	en_US
dc.contributor.author	Weiss, ST	en_US
dc.date.available	2005-12-12	en_US
dc.date.issued	2006-04-01	en_US
dc.identifier.citation	Journal of Allergy and Clinical Immunology, 2006, 117 (4), pp. 931 - 938	en_US
dc.identifier.issn	0091-6749	en_US
dc.identifier.uri	http://hdl.handle.net/10453/26018
dc.description.abstract	Background: N-3 and n-6 polyunsaturated fatty acids (PUFAs) have been hypothesized to have opposing influences on neonatal immune responses that might influence the risk of allergy or asthma. However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development. Objective: We evaluated whether cord blood fatty acid levels were related to neonatal immune responses and whether n-3 and n-6 PUFA responses differed. Methods: We examined the relation of cord blood plasma n-3 and n-6 PUFAs (n = 192) to antigen- and mitogen-stimulated cord blood lymphocyte proliferation (n = 191) and cytokine (IL-13 and IFN-γ; n = 167) secretion in a US birth cohort. Results: Higher levels of n-6 linoleic acid were correlated with higher IL-13 levels in response to Bla g 2 (cockroach, P = .009) and Der f 1 (dust mite, P = .02). Higher n-3 EPA and n-6 AA levels were each correlated with reduced lymphocyte proliferation and IFN-γ levels in response to Bla g 2 and Der f 1 stimulation. Controlling for potential confounders, EPA and AA had similar independent effects on reduced allergen-stimulated IFN-γ levels. If neonates had either EPA or AA levels in the highest quartile, their Der f 1 IFN-γ levels were 90% lower (P = .0001) than those with both EPA and AA levels in the lowest 3 quartiles. Reduced AA/EPA ratio was associated with reduced allergen-stimulated IFN-γ level. Conclusion: Increased levels of fetal n-3 EPA and n-6 AA might have similar effects on attenuation of cord blood lymphocyte proliferation and IFN-γ secretion. Clinical implications: The implications of these findings for allergy or asthma development are not yet known. © 2006 American Academy of Allergy, Asthma and Immunology.	en_US
dc.relation.ispartof	Journal of Allergy and Clinical Immunology	en_US
dc.relation.isbasedon	10.1016/j.jaci.2005.12.1322	en_US
dc.subject.classification	Allergy	en_US
dc.subject.mesh	Lymphocytes	en_US
dc.subject.mesh	Fetal Blood	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Fatty Acids, Omega-3	en_US
dc.subject.mesh	Fatty Acids	en_US
dc.subject.mesh	Fatty Acids, Omega-6	en_US
dc.subject.mesh	Interleukin-13	en_US
dc.subject.mesh	Allergens	en_US
dc.subject.mesh	Cell Proliferation	en_US
dc.subject.mesh	Infant, Newborn	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Interferon-gamma	en_US
dc.subject.mesh	In Vitro Techniques	en_US
dc.title	Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-γ	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	117	en_US
utslib.for	010402 Biostatistics	en_US
utslib.for	1107 Immunology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	117	en_US

Abstract:

Background: N-3 and n-6 polyunsaturated fatty acids (PUFAs) have been hypothesized to have opposing influences on neonatal immune responses that might influence the risk of allergy or asthma. However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development. Objective: We evaluated whether cord blood fatty acid levels were related to neonatal immune responses and whether n-3 and n-6 PUFA responses differed. Methods: We examined the relation of cord blood plasma n-3 and n-6 PUFAs (n = 192) to antigen- and mitogen-stimulated cord blood lymphocyte proliferation (n = 191) and cytokine (IL-13 and IFN-γ; n = 167) secretion in a US birth cohort. Results: Higher levels of n-6 linoleic acid were correlated with higher IL-13 levels in response to Bla g 2 (cockroach, P = .009) and Der f 1 (dust mite, P = .02). Higher n-3 EPA and n-6 AA levels were each correlated with reduced lymphocyte proliferation and IFN-γ levels in response to Bla g 2 and Der f 1 stimulation. Controlling for potential confounders, EPA and AA had similar independent effects on reduced allergen-stimulated IFN-γ levels. If neonates had either EPA or AA levels in the highest quartile, their Der f 1 IFN-γ levels were 90% lower (P = .0001) than those with both EPA and AA levels in the lowest 3 quartiles. Reduced AA/EPA ratio was associated with reduced allergen-stimulated IFN-γ level. Conclusion: Increased levels of fetal n-3 EPA and n-6 AA might have similar effects on attenuation of cord blood lymphocyte proliferation and IFN-γ secretion. Clinical implications: The implications of these findings for allergy or asthma development are not yet known. © 2006 American Academy of Allergy, Asthma and Immunology.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/26018