Within-home versus between-home variability of house dust endotoxin in a birth cohort

Abraham, JH; Gold, DR; Dockery, DW; Ryan, L; Park, JH; Milton, DK

Within-home versus between-home variability of house dust endotoxin in a birth cohort

Abraham, JH Gold, DR Dockery, DW Ryan, L

Park, JH Milton, DK

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Publication Type:: Journal Article
Citation:: Environmental Health Perspectives, 2005, 113 (11), pp. 1516 - 1521
Issue Date:: 2005-11-01

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Field	Value	Language
dc.contributor.author	Abraham, JH	en_US
dc.contributor.author	Gold, DR	en_US
dc.contributor.author	Dockery, DW	en_US
dc.contributor.author	Ryan, L https://orcid.org/0000-0001-5957-2490	en_US
dc.contributor.author	Park, JH	en_US
dc.contributor.author	Milton, DK	en_US
dc.date.issued	2005-11-01	en_US
dc.identifier.citation	Environmental Health Perspectives, 2005, 113 (11), pp. 1516 - 1521	en_US
dc.identifier.issn	0091-6765	en_US
dc.identifier.uri	http://hdl.handle.net/10453/88307
dc.description.abstract	Endotoxin exposure has been proposed as an environmental determinant of allergen responses in children. To better understand the implications of using a single measurement of house dust endotoxin to characterize exposure in the first year of life, we evaluated room-specific within-home and between-home variability in dust endotoxin obtained from 470 households in Boston, Massachusetts. Homes were sampled up to two times over 5-11 months, We analyzed 1,287 dust samples from the kitchen, family room, and baby's bedroom for endotoxin. We fit a mixed-effects model to estimate mean levels and the variation of endotoxin between homes, between rooms, and between sampling times. Endotoxin ranged from 2 to 1,945 units per milligram of dust. Levels were highest during summer and lowest in the winter. Mean endotoxin levels varied significantly from room to room. Cross-sectionally, endotoxin was moderately correlated between family room and bedroom floor (r = 0.30), between family room and kitchen (r = 0.32), and between kitchen and bedroom (r = 0.42). Adjusting for season, the correlation of endotoxin levels within homes over time was 0.65 for both the bedroom and kitchen and 0.54 for the family room. The temporal within-home variance of endotoxin was lowest for bedroom floor samples and highest for kitchen samples. Between-home variance was lowest in the family room and highest for kitchen samples. Adjusting, for season, within-home variation was less than between-home variation for all three rooms. These results suggest that room-to-room and home-to-home differences in endotoxin influence the total variability more than factors affecting endotoxin levels within a room over time.	en_US
dc.relation.ispartof	Environmental Health Perspectives	en_US
dc.relation.isbasedon	10.1289/ehp.7632	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Gram-Negative Bacteria	en_US
dc.subject.mesh	Dust	en_US
dc.subject.mesh	Endotoxins	en_US
dc.subject.mesh	Air Pollutants	en_US
dc.subject.mesh	Limulus Test	en_US
dc.subject.mesh	Cohort Studies	en_US
dc.subject.mesh	Housing	en_US
dc.subject.mesh	Air Pollution, Indoor	en_US
dc.subject.mesh	Environmental Monitoring	en_US
dc.subject.mesh	Infant	en_US
dc.subject.mesh	Infant, Newborn	en_US
dc.subject.mesh	Boston	en_US
dc.title	Within-home versus between-home variability of house dust endotoxin in a birth cohort	en_US
dc.type	Journal Article
utslib.citation.volume	11	en_US
utslib.citation.volume	113	en_US
utslib.for	010402 Biostatistics	en_US
utslib.for	05 Environmental Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	11	en_US
pubs.publication-status	Published	en_US
pubs.volume	113	en_US

Abstract:

Endotoxin exposure has been proposed as an environmental determinant of allergen responses in children. To better understand the implications of using a single measurement of house dust endotoxin to characterize exposure in the first year of life, we evaluated room-specific within-home and between-home variability in dust endotoxin obtained from 470 households in Boston, Massachusetts. Homes were sampled up to two times over 5-11 months, We analyzed 1,287 dust samples from the kitchen, family room, and baby's bedroom for endotoxin. We fit a mixed-effects model to estimate mean levels and the variation of endotoxin between homes, between rooms, and between sampling times. Endotoxin ranged from 2 to 1,945 units per milligram of dust. Levels were highest during summer and lowest in the winter. Mean endotoxin levels varied significantly from room to room. Cross-sectionally, endotoxin was moderately correlated between family room and bedroom floor (r = 0.30), between family room and kitchen (r = 0.32), and between kitchen and bedroom (r = 0.42). Adjusting for season, the correlation of endotoxin levels within homes over time was 0.65 for both the bedroom and kitchen and 0.54 for the family room. The temporal within-home variance of endotoxin was lowest for bedroom floor samples and highest for kitchen samples. Between-home variance was lowest in the family room and highest for kitchen samples. Adjusting, for season, within-home variation was less than between-home variation for all three rooms. These results suggest that room-to-room and home-to-home differences in endotoxin influence the total variability more than factors affecting endotoxin levels within a room over time.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/26242