Metalloproteomics: principles, challenges and applications to neurodegeneration

Lothian, A; Hare, D; Grimm, R; Ryan, T; Masters, C; Roberts, B

Metalloproteomics: principles, challenges and applications to neurodegeneration

Lothian, A Hare, D Grimm, R Ryan, T Masters, C Roberts, B

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Publisher:: Frontiers
Publication Type:: Journal Article
Citation:: Lothian, Amber et al. 2013, 'Metalloproteomics: principles, challenges and applications to neurodegeneration', Frontiers in Aging Neuroscience, vol. 5, no. 1, pp. 35-1-35-7.
Issue Date:: 2013

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Field	Value	Language
dc.contributor.author	Lothian, A	en_US
dc.contributor.author	Hare, D	en_US
dc.contributor.author	Grimm, R	en_US
dc.contributor.author	Ryan, T	en_US
dc.contributor.author	Masters, C	en_US
dc.contributor.author	Roberts, B	en_US
dc.date.accessioned	2014-04-14T02:45:39Z
dc.date.available	2014-04-14T02:45:39Z
dc.date.issued	2013	en_US
dc.identifier	2012008358	en_US
dc.identifier.citation	Lothian, Amber et al. 2013, 'Metalloproteomics: principles, challenges and applications to neurodegeneration', Frontiers in Aging Neuroscience, vol. 5, no. 1, pp. 35-1-35-7.	en_US
dc.identifier.issn	1663-4365	en_US
dc.identifier.other	C1	en_US
dc.identifier.uri	http://hdl.handle.net/10453/26463
dc.description.abstract	Trace elements are required for a variety of normal biological functions. As our understanding of neurodegenerative disease advances we are identifying a number of metalloenzymes involved in disease process. Thus, the future of metals in neurobiology will rely more on detailed information regarding what metalloenzymes are present and how they are involved in the pathophysiology of disease. To gain this detailed information, we will rely less on bulk measures of the amount of a trace elements in a particular tissue and turn to metalloproteomic techniques to help elucidate both metalloprotein structure and function. Recent advances in metalloproteomics will translate to a richer understanding of the mechanism and precise role of metalloenzymes and proteins in the brain.	en_US
dc.publisher	Frontiers	en_US
dc.relation.ispartof	Verified OK	en_US
dc.relation.ispartof	Frontiers in Aging Neuroscience	en_US
dc.relation.isbasedon	http://dx.doi.org/10.3389/fnagi.2013.00035	en_US
dc.subject	metalloproteomics, LC-ICP-MS, metals in neurodegeneration, quantitative methods, hyphenated ICP-MS techniques	en_US
dc.subject.classification	Medicinal and Biomolecular Chemistry	en_US
dc.title	Metalloproteomics: principles, challenges and applications to neurodegeneration	en_US
dc.type	Journal article
utslib.citation.volume	5	en_US
utslib.citation.number	1	en_US
utslib.location	Switzerland	en_US
utslib.citation.startpage	35-1	en_US
utslib.citation.endpage	35-7	en_US
utslib.identifier.org	SCI.School of Chemistry and Forensic Science	en_US
utslib.for	030400	en_US
utslib.percentage	100	en_US
utslib.copyright.status	open_access

Abstract:

Trace elements are required for a variety of normal biological functions. As our understanding of neurodegenerative disease advances we are identifying a number of metalloenzymes involved in disease process. Thus, the future of metals in neurobiology will rely more on detailed information regarding what metalloenzymes are present and how they are involved in the pathophysiology of disease. To gain this detailed information, we will rely less on bulk measures of the amount of a trace elements in a particular tissue and turn to metalloproteomic techniques to help elucidate both metalloprotein structure and function. Recent advances in metalloproteomics will translate to a richer understanding of the mechanism and precise role of metalloenzymes and proteins in the brain.

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http://hdl.handle.net/10453/26463