Protein Binding Interfaces and Their Binding Hot Spot Prediction: A Survey

Li, J; Liu, Q

Protein Binding Interfaces and Their Binding Hot Spot Prediction: A Survey

Li, J

Liu, Q

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Publisher:: Springer
Publication Type:: Chapter
Citation:: Bioinformatics for Diagnosis, Prognosis and Treatment of Complex Diseases, 2013, 1, pp. 79 - 106
Issue Date:: 2013-01

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Field	Value	Language
dc.contributor.author	Li, J https://orcid.org/0000-0003-1833-7413	en_US
dc.contributor.author	Liu, Q	en_US
dc.contributor.editor	Shen, B	en_US
dc.date.issued	2013-01	en_US
dc.identifier.citation	Bioinformatics for Diagnosis, Prognosis and Treatment of Complex Diseases, 2013, 1, pp. 79 - 106	en_US
dc.identifier.isbn	978-94-007-7974-7	en_US
dc.identifier.uri	http://hdl.handle.net/10453/27113
dc.description.abstract	In living organisms, genes are the blueprints or library, specifying instructions for building proteins. Proteins constitute the bulk of cells. Proteins mutual binding and interactions play a vital role in numerous functions and activities, such as signal transduction, enzymatic reactions, immunoreactions and inter-cellular communications. This survey provides basic knowledge of proteins and protein binding. First, we describe proteins fundamental elements, structures and functions. In Sect. 5.2, we present concepts related to protein binding and interactions. In Sect. 5.3, we explain why protein binding interfaces have a uneven distribution of binding free energy. In the Sects. 5.4 and 5.5, we explain why protein interfaces are complicated and how the current studies deal with this difficult problem. In Sect. 5.6, we present an overview on methods to model and predict binding free energy of protein interactions. Section 5.7 concludes this survey with a summary.	en_US
dc.publisher	Springer	en_US
dc.relation	http://purl.org/au-research/grants/arc/DP130102124
dc.relation.ispartof	Bioinformatics for Diagnosis, Prognosis and Treatment of Complex Diseases	en_US
dc.relation.isbasedon	10.1007/978-94-007-7975-4_5	en_US
dc.title	Protein Binding Interfaces and Their Binding Hot Spot Prediction: A Survey	en_US
dc.type	Chapter
utslib.location	German	en_US
utslib.for	060102 Bioinformatics	en_US
utslib.citation.edition	1	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - AAI - Advanced Analytics Institute Research Centre
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.consider-herdc	true	en_US
pubs.edition	1	en_US
pubs.place-of-publication	German	en_US

Abstract:

In living organisms, genes are the blueprints or library, specifying instructions for building proteins. Proteins constitute the bulk of cells. Proteins mutual binding and interactions play a vital role in numerous functions and activities, such as signal transduction, enzymatic reactions, immunoreactions and inter-cellular communications. This survey provides basic knowledge of proteins and protein binding. First, we describe proteins fundamental elements, structures and functions. In Sect. 5.2, we present concepts related to protein binding and interactions. In Sect. 5.3, we explain why protein binding interfaces have a uneven distribution of binding free energy. In the Sects. 5.4 and 5.5, we explain why protein interfaces are complicated and how the current studies deal with this difficult problem. In Sect. 5.6, we present an overview on methods to model and predict binding free energy of protein interactions. Section 5.7 concludes this survey with a summary.

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http://hdl.handle.net/10453/27113