Characterization of the surface biocompatibility of an electrospun nylon 6/CaP nanofiber scaffold using osteoblasts

Abdal-hay, A; Tijing, LD; Lim, JK

Characterization of the surface biocompatibility of an electrospun nylon 6/CaP nanofiber scaffold using osteoblasts

Abdal-hay, A Tijing, LD

Lim, JK

Permalink

Publication Type:: Journal Article
Citation:: Chemical Engineering Journal, 2013, 215-216 pp. 57 - 64
Issue Date:: 2013-01-05

Closed Access

	Filename	Description	Size
	2012002579OK.pdf		1.11 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Abdal-hay, A	en_US
dc.contributor.author	Tijing, LD https://orcid.org/0000-0001-9398-6355	en_US
dc.contributor.author	Lim, JK	en_US
dc.date.issued	2013-01-05	en_US
dc.identifier.citation	Chemical Engineering Journal, 2013, 215-216 pp. 57 - 64	en_US
dc.identifier.issn	1385-8947	en_US
dc.identifier.uri	http://hdl.handle.net/10453/27899
dc.description.abstract	The purpose of this research is to improve the biocompatibility of bone tissue engineering scaffolds using a one-step electrospinning process. Calcium phosphate (CaP) was coated on the surface of nylon 6 (N6) nanofibers to form an ultrathin layer, thereby increasing surface roughness and wettability of the N6 nanofiber membrane in order to further improve implant tissue integration. The morphology, composition, chemical interaction bonding and mechanical properties of CaP-coated N6 nanofibers were characterized. The wettability of the scaffold was measured in terms of the water contact angle, and the results indicated that N6 fibers coated with an ultrathin layer of CaP exhibited an excellent surface wettability (water contact angle = 0°). Mechanical testing revealed higher properties of coated CaP layers compared to a plain N6 mat. The biological response induced by the surface modifications of N6 fibers was evaluated by in vitro cell culture with MC3T3-E1 osteoblasts cells. It was found that CaP-coated N6 nanofibrous matrices definitely favored cell proliferation, with the efficiency dependent upon the coating technique. A combination of a nanoscale fibrous structure and a CaP coating could mimic the structure, composition and function of bone tissues. © 2012 Elsevier B.V.	en_US
dc.relation.ispartof	Chemical Engineering Journal	en_US
dc.relation.isbasedon	10.1016/j.cej.2012.10.046	en_US
dc.subject.classification	Chemical Engineering	en_US
dc.title	Characterization of the surface biocompatibility of an electrospun nylon 6/CaP nanofiber scaffold using osteoblasts	en_US
dc.type	Journal Article
utslib.citation.volume	215-216	en_US
utslib.for	0904 Chemical Engineering	en_US
utslib.for	0905 Civil Engineering	en_US
utslib.for	0907 Environmental Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	215-216	en_US

Abstract:

The purpose of this research is to improve the biocompatibility of bone tissue engineering scaffolds using a one-step electrospinning process. Calcium phosphate (CaP) was coated on the surface of nylon 6 (N6) nanofibers to form an ultrathin layer, thereby increasing surface roughness and wettability of the N6 nanofiber membrane in order to further improve implant tissue integration. The morphology, composition, chemical interaction bonding and mechanical properties of CaP-coated N6 nanofibers were characterized. The wettability of the scaffold was measured in terms of the water contact angle, and the results indicated that N6 fibers coated with an ultrathin layer of CaP exhibited an excellent surface wettability (water contact angle = 0°). Mechanical testing revealed higher properties of coated CaP layers compared to a plain N6 mat. The biological response induced by the surface modifications of N6 fibers was evaluated by in vitro cell culture with MC3T3-E1 osteoblasts cells. It was found that CaP-coated N6 nanofibrous matrices definitely favored cell proliferation, with the efficiency dependent upon the coating technique. A combination of a nanoscale fibrous structure and a CaP coating could mimic the structure, composition and function of bone tissues. © 2012 Elsevier B.V.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/27899