Bone regeneration of rat tibial defect by zinc-tricalcium phosphate (Zn-TCP) synthesized from porous foraminifera carbonate macrospheres

Chou, J; Hao, J; Kuroda, S; Bishop, D; Ben-Nissan, B; Milthorpe, B; Otsuka, M

Bone regeneration of rat tibial defect by zinc-tricalcium phosphate (Zn-TCP) synthesized from porous foraminifera carbonate macrospheres

Chou, J

Hao, J Kuroda, S Bishop, D

Ben-Nissan, B Milthorpe, B

Otsuka, M

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Publication Type:: Journal Article
Citation:: Marine Drugs, 2013, 11 (12), pp. 5148 - 5158
Issue Date:: 2013-12-01

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Field	Value	Language
dc.contributor.author	Chou, J https://orcid.org/0000-0002-7472-8016	en_US
dc.contributor.author	Hao, J	en_US
dc.contributor.author	Kuroda, S	en_US
dc.contributor.author	Bishop, D https://orcid.org/0000-0002-6533-4410	en_US
dc.contributor.author	Ben-Nissan, B	en_US
dc.contributor.author	Milthorpe, B https://orcid.org/0000-0002-0867-9586	en_US
dc.contributor.author	Otsuka, M	en_US
dc.date.available	2013-12-04	en_US
dc.date.issued	2013-12-01	en_US
dc.identifier.citation	Marine Drugs, 2013, 11 (12), pp. 5148 - 5158	en_US
dc.identifier.uri	http://hdl.handle.net/10453/27921
dc.description.abstract	Foraminifera carbonate exoskeleton was hydrothermally converted to biocompatible and biodegradable zinc-tricalcium phosphate (Zn-TCP) as an alternative biomimetic material for bone fracture repair. Zn-TCP samples implanted in a rat tibial defect model for eight weeks were compared with unfilled defect and beta-tricalcium phosphate showing accelerated bone regeneration compared with the control groups, with statistically significant bone mineral density and bone mineral content growth. CT images of the defect showed restoration of cancellous bone in Zn-TCP and only minimal growth in control group. Histological slices reveal bone in-growth within the pores and porous chamber of the material detailing good bone-material integration with the presence of blood vessels. These results exhibit the future potential of biomimetic Zn-TCP as bone grafts for bone fracture repair. © 2013 by the authors; licensee MDPI.	en_US
dc.relation.ispartof	Marine Drugs	en_US
dc.relation.isbasedon	10.3390/md11125148	en_US
dc.subject.classification	Medicinal & Biomolecular Chemistry	en_US
dc.subject.mesh	Tibia	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Rats	en_US
dc.subject.mesh	Rats, Wistar	en_US
dc.subject.mesh	Carbonates	en_US
dc.subject.mesh	Calcium Phosphates	en_US
dc.subject.mesh	Zinc	en_US
dc.subject.mesh	Biocompatible Materials	en_US
dc.subject.mesh	Bone Regeneration	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Porosity	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Foraminifera	en_US
dc.title	Bone regeneration of rat tibial defect by zinc-tricalcium phosphate (Zn-TCP) synthesized from porous foraminifera carbonate macrospheres	en_US
dc.type	Journal Article
utslib.citation.volume	12	en_US
utslib.citation.volume	11	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	0306 Physical Chemistry (incl. Structural)	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	12	en_US
pubs.publication-status	Published	en_US
pubs.volume	11	en_US

Abstract:

Foraminifera carbonate exoskeleton was hydrothermally converted to biocompatible and biodegradable zinc-tricalcium phosphate (Zn-TCP) as an alternative biomimetic material for bone fracture repair. Zn-TCP samples implanted in a rat tibial defect model for eight weeks were compared with unfilled defect and beta-tricalcium phosphate showing accelerated bone regeneration compared with the control groups, with statistically significant bone mineral density and bone mineral content growth. CT images of the defect showed restoration of cancellous bone in Zn-TCP and only minimal growth in control group. Histological slices reveal bone in-growth within the pores and porous chamber of the material detailing good bone-material integration with the presence of blood vessels. These results exhibit the future potential of biomimetic Zn-TCP as bone grafts for bone fracture repair. © 2013 by the authors; licensee MDPI.

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http://hdl.handle.net/10453/27921