Association between abdominal obesity and fracture risk: A prospective study

Yang, S; Nguyen, ND; Center, JR; Eisman, JA; Nguyen, TV

Association between abdominal obesity and fracture risk: A prospective study

Yang, S Nguyen, ND Center, JR Eisman, JA Nguyen, TV

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Publication Type:: Journal Article
Citation:: Journal of Clinical Endocrinology and Metabolism, 2013, 98 (6), pp. 2478 - 2483
Issue Date:: 2013-06-01

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Field	Value	Language
dc.contributor.author	Yang, S	en_US
dc.contributor.author	Nguyen, ND	en_US
dc.contributor.author	Center, JR	en_US
dc.contributor.author	Eisman, JA	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.date.issued	2013-06-01	en_US
dc.identifier.citation	Journal of Clinical Endocrinology and Metabolism, 2013, 98 (6), pp. 2478 - 2483	en_US
dc.identifier.issn	0021-972X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28724
dc.description.abstract	Context: Higher body weight is associated with greater bone mineral density (BMD) and lower fracture risk. However, the relationship between abdominal fat mass (aFM) and fracture risk is unclear because of limited prospective data. The present study sought to examine the association between aFM, BMD, and fracture risk. Methods: The study was designed as a prospective investigation, in which a sample of 1126 participants (360 men and 766 women) aged 50 years or older had been continuously followed up for an average of 5 years. The mean age of participants was 71 years (range, 57-94 years). At baseline, BMD at the femoral neck and lumbar spine and aFM were measured by dual-energy X-ray absorptiometry. The incidence of low-trauma and nonpathological fractures was ascertained prospectively from X-ray reports. Results: During the follow-up period, 19 men and 107 women had sustained a fracture. In women, each 1-kg lower aFM was associated with a 50% higher risk of fracture (hazard ratio [HR], 1.50;95% confidence interval [CI], 1.10-2.05) after adjustment for age, femoral neck BMD, falls, stature, physical activity, and prior fracture. Subgroup analysis by fracture type found that the association was mainly observed in clinical vertebral fracture (HR, 1.96; 95% CI, 1.22-3.13). In men, although there was no statistically significant association between aFM and fracture risk (HR, 1.15; 95% CI, 0.58-2.25), the strength of this finding is affected negatively by the low number of fractures. Conclusions: Lower abdominal fat was significantly associated with an higher fracture risk in women. Copyright © 2013 by The Endocrine Society.	en_US
dc.relation.ispartof	Journal of Clinical Endocrinology and Metabolism	en_US
dc.relation.isbasedon	10.1210/jc.2012-2958	en_US
dc.subject.classification	Endocrinology & Metabolism	en_US
dc.subject.mesh	Adipose Tissue	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Risk	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Aged, 80 and over	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Fractures, Bone	en_US
dc.subject.mesh	Obesity, Abdominal	en_US
dc.title	Association between abdominal obesity and fracture risk: A prospective study	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	98	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	98	en_US

Abstract:

Context: Higher body weight is associated with greater bone mineral density (BMD) and lower fracture risk. However, the relationship between abdominal fat mass (aFM) and fracture risk is unclear because of limited prospective data. The present study sought to examine the association between aFM, BMD, and fracture risk. Methods: The study was designed as a prospective investigation, in which a sample of 1126 participants (360 men and 766 women) aged 50 years or older had been continuously followed up for an average of 5 years. The mean age of participants was 71 years (range, 57-94 years). At baseline, BMD at the femoral neck and lumbar spine and aFM were measured by dual-energy X-ray absorptiometry. The incidence of low-trauma and nonpathological fractures was ascertained prospectively from X-ray reports. Results: During the follow-up period, 19 men and 107 women had sustained a fracture. In women, each 1-kg lower aFM was associated with a 50% higher risk of fracture (hazard ratio [HR], 1.50;95% confidence interval [CI], 1.10-2.05) after adjustment for age, femoral neck BMD, falls, stature, physical activity, and prior fracture. Subgroup analysis by fracture type found that the association was mainly observed in clinical vertebral fracture (HR, 1.96; 95% CI, 1.22-3.13). In men, although there was no statistically significant association between aFM and fracture risk (HR, 1.15; 95% CI, 0.58-2.25), the strength of this finding is affected negatively by the low number of fractures. Conclusions: Lower abdominal fat was significantly associated with an higher fracture risk in women. Copyright © 2013 by The Endocrine Society.

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http://hdl.handle.net/10453/28724