The shifting trajectory of growth in femur length during gestation

Bjørnerem, A; Johnsen, SL; Nguyen, TV; Kiserud, T; Seeman, E

The shifting trajectory of growth in femur length during gestation

Bjørnerem, A Johnsen, SL Nguyen, TV

Kiserud, T Seeman, E

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Publication Type:: Journal Article
Citation:: Journal of Bone and Mineral Research, 2010, 25 (5), pp. 1029 - 1033
Issue Date:: 2010-05-01

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Field	Value	Language
dc.contributor.author	Bjørnerem, A	en_US
dc.contributor.author	Johnsen, SL	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.contributor.author	Kiserud, T	en_US
dc.contributor.author	Seeman, E	en_US
dc.date.issued	2010-05-01	en_US
dc.identifier.citation	Journal of Bone and Mineral Research, 2010, 25 (5), pp. 1029 - 1033	en_US
dc.identifier.issn	0884-0431	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28788
dc.description.abstract	Bone size is a determinant of bone strength and tracks in its percentile of origin during childhood and adolescence. We hypothesized that the ranking of an individual's femur length (FL) is established in early gestation and tracks thereafter. Fetal FL was measured serially using 2D ultrasound in 625 Norwegian fetuses. Tracking was assessed using Pearson correlation, a generalized estimating equation model, and by calculating the proportion of fetuses whose FL remained within the same quartile. Baseline FL Z-score (weeks 10 to 19) and later measurements correlated, but more weakly as gestation advanced: r = 0.59 (weeks 20 to 26); r = 0.45 (weeks 27 to 33); and r = 0.32 (weeks 34 to 39) (p<0.001). Tracking within the same quartile throughout gestation occurred in 13% of fetuses. Of the 87% deviating, 21% returned to the quartile of origin, so 34% began and ended in the same quartile, 38% deviated by one quartile, and 28% deviated by two or more quartiles by the end of gestation. A standard deviation higher baseline FL Z-score, placental weight (150 g), maternal height (5 cm), and weight (10 kg), was associated with a 0.25, 0.15, 0.10, and 0.05 SD higher FL Z-score at the end of gestation, respectively (p ranging from <0.001 to 0.02). Tracking within the same percentile throughout the whole of gestation, as suggest by growth charts, is uncommon. Deviation from tracking is more common and is the result of changes in growth velocity within and between fetuses and is partly influenced by maternal, fetal, and placental factors. © 2010 American Society for Bone and Mineral Research.	en_US
dc.relation.ispartof	Journal of Bone and Mineral Research	en_US
dc.relation.isbasedon	10.1359/jbmr.091107	en_US
dc.subject.classification	Anatomy & Morphology	en_US
dc.subject.mesh	Femur	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Body Weight	en_US
dc.subject.mesh	Ultrasonography, Prenatal	en_US
dc.subject.mesh	Body Height	en_US
dc.subject.mesh	Fetal Development	en_US
dc.subject.mesh	Gestational Age	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Infant, Newborn	en_US
dc.subject.mesh	Female	en_US
dc.title	The shifting trajectory of growth in femur length during gestation	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	25	en_US
utslib.for	110306 Endocrinology	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	09 Engineering	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	25	en_US

Abstract:

Bone size is a determinant of bone strength and tracks in its percentile of origin during childhood and adolescence. We hypothesized that the ranking of an individual's femur length (FL) is established in early gestation and tracks thereafter. Fetal FL was measured serially using 2D ultrasound in 625 Norwegian fetuses. Tracking was assessed using Pearson correlation, a generalized estimating equation model, and by calculating the proportion of fetuses whose FL remained within the same quartile. Baseline FL Z-score (weeks 10 to 19) and later measurements correlated, but more weakly as gestation advanced: r = 0.59 (weeks 20 to 26); r = 0.45 (weeks 27 to 33); and r = 0.32 (weeks 34 to 39) (p<0.001). Tracking within the same quartile throughout gestation occurred in 13% of fetuses. Of the 87% deviating, 21% returned to the quartile of origin, so 34% began and ended in the same quartile, 38% deviated by one quartile, and 28% deviated by two or more quartiles by the end of gestation. A standard deviation higher baseline FL Z-score, placental weight (150 g), maternal height (5 cm), and weight (10 kg), was associated with a 0.25, 0.15, 0.10, and 0.05 SD higher FL Z-score at the end of gestation, respectively (p ranging from <0.001 to 0.02). Tracking within the same percentile throughout the whole of gestation, as suggest by growth charts, is uncommon. Deviation from tracking is more common and is the result of changes in growth velocity within and between fetuses and is partly influenced by maternal, fetal, and placental factors. © 2010 American Society for Bone and Mineral Research.

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http://hdl.handle.net/10453/28788