Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma

Favaloro, J; Liyadipitiya, T; Brown, R; Yang, S; Suen, H; Woodland, N; Nassif, N; Hart, D; Fromm, P; Weatherburn, C; Gibson, J; Ho, PJ; Joshua, D

Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma

Favaloro, J Liyadipitiya, T Brown, R Yang, S Suen, H Woodland, N Nassif, N

Hart, D Fromm, P Weatherburn, C Gibson, J Ho, PJ Joshua, D

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Publication Type:: Journal Article
Citation:: Leukemia and Lymphoma, 2014, 55 (12), pp. 2893 - 2900
Issue Date:: 2014-01-01

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Field	Value	Language
dc.contributor.author	Favaloro, J	en_US
dc.contributor.author	Liyadipitiya, T	en_US
dc.contributor.author	Brown, R	en_US
dc.contributor.author	Yang, S	en_US
dc.contributor.author	Suen, H	en_US
dc.contributor.author	Woodland, N	en_US
dc.contributor.author	Nassif, N https://orcid.org/0000-0003-2675-8322	en_US
dc.contributor.author	Hart, D	en_US
dc.contributor.author	Fromm, P	en_US
dc.contributor.author	Weatherburn, C	en_US
dc.contributor.author	Gibson, J	en_US
dc.contributor.author	Ho, PJ	en_US
dc.contributor.author	Joshua, D	en_US
dc.date.issued	2014-01-01	en_US
dc.identifier.citation	Leukemia and Lymphoma, 2014, 55 (12), pp. 2893 - 2900	en_US
dc.identifier.issn	1042-8194	en_US
dc.identifier.uri	http://hdl.handle.net/10453/30674
dc.description.abstract	© 2014 Informa UK, Ltd. Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of cells that have been implicated as inhibitors of lymphopoiesis in patients with malignancies. They have a consensus phenotype of CD33+/CD11b+/HLA-DRlo/-and can be further divided into CD15 + granulocytic (G-MDSC) and CD14 + monocytic (M-MDSC) subsets. We characterized MDSCs in patients with multiple myeloma (MM) and found a significant increase in G-MDSCs in the blood of patients with progressive MM. Flow-sorted MDSCs from patients with MM induced the generation of regulatory T cells (Treg). MDSCs from both patients with MM and aged-matched controls demonstrated a dose-dependent inhibition of lymphocyte proliferation in carboxyfluorescein succinimidyl ester (CFSE)-tracking experiments. Granulocyte colony stimulating factor (G-CSF) administered to induce stem cell mobilization caused an increase in the number of MDSCs in the peripheral blood of patients with MM and a concentration of these immune-suppressive cells in peripheral blood stem cell collections. MDSCs are likely to cause immune dysfunction in patients with MM.	en_US
dc.relation.ispartof	Leukemia and Lymphoma	en_US
dc.relation.isbasedon	10.3109/10428194.2014.904511	en_US
dc.subject.classification	Immunology	en_US
dc.subject.mesh	Myeloid Cells	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Multiple Myeloma	en_US
dc.subject.mesh	Granulocyte Colony-Stimulating Factor	en_US
dc.subject.mesh	Antigens, Surface	en_US
dc.subject.mesh	Cell Count	en_US
dc.subject.mesh	Immunophenotyping	en_US
dc.subject.mesh	Lymphocyte Activation	en_US
dc.subject.mesh	Phenotype	en_US
dc.subject.mesh	T-Lymphocytes, Regulatory	en_US
dc.subject.mesh	Immunomodulation	en_US
dc.title	Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma	en_US
dc.type	Journal Article
utslib.citation.volume	12	en_US
utslib.citation.volume	55	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	12	en_US
pubs.publication-status	Published	en_US
pubs.volume	55	en_US

Abstract:

© 2014 Informa UK, Ltd. Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of cells that have been implicated as inhibitors of lymphopoiesis in patients with malignancies. They have a consensus phenotype of CD33+/CD11b+/HLA-DRlo/-and can be further divided into CD15 + granulocytic (G-MDSC) and CD14 + monocytic (M-MDSC) subsets. We characterized MDSCs in patients with multiple myeloma (MM) and found a significant increase in G-MDSCs in the blood of patients with progressive MM. Flow-sorted MDSCs from patients with MM induced the generation of regulatory T cells (Treg). MDSCs from both patients with MM and aged-matched controls demonstrated a dose-dependent inhibition of lymphocyte proliferation in carboxyfluorescein succinimidyl ester (CFSE)-tracking experiments. Granulocyte colony stimulating factor (G-CSF) administered to induce stem cell mobilization caused an increase in the number of MDSCs in the peripheral blood of patients with MM and a concentration of these immune-suppressive cells in peripheral blood stem cell collections. MDSCs are likely to cause immune dysfunction in patients with MM.

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http://hdl.handle.net/10453/30674