Marine structure derived calcium phosphate-polymer biocomposites for local antibiotic delivery

Macha, IJ; Cazalbou, S; Ben-Nissan, B; Harvey, KL; Milthorpe, B

Marine structure derived calcium phosphate-polymer biocomposites for local antibiotic delivery

Macha, IJ

Cazalbou, S Ben-Nissan, B Harvey, KL Milthorpe, B

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Publication Type:: Journal Article
Citation:: Marine Drugs, 2015, 13 (1), pp. 666 - 680
Issue Date:: 2015-01-01

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Field	Value	Language
dc.contributor.author	Macha, IJ https://orcid.org/0000-0002-7517-4537	en_US
dc.contributor.author	Cazalbou, S	en_US
dc.contributor.author	Ben-Nissan, B	en_US
dc.contributor.author	Harvey, KL	en_US
dc.contributor.author	Milthorpe, B https://orcid.org/0000-0002-0867-9586	en_US
dc.date.available	2015-01-12	en_US
dc.date.issued	2015-01-01	en_US
dc.identifier.citation	Marine Drugs, 2015, 13 (1), pp. 666 - 680	en_US
dc.identifier.uri	http://hdl.handle.net/10453/33027
dc.description.abstract	© 2015 by the authors. Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca2+ for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against Staphylococcus aureus (S. aureus) (SH1000) even at high concentration of bacteria. The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release. Clinical release profiles can be easily tuned from drug-HAp physicochemical interactions and degradation kinetics of polymer matrix. The developed systems could be applied to prevent microbial adhesion to medical implant surfaces and to treat infections mainly caused by S. aureus in surgery.	en_US
dc.relation.ispartof	Marine Drugs	en_US
dc.relation.isbasedon	10.3390/md13010666	en_US
dc.subject.classification	Medicinal & Biomolecular Chemistry	en_US
dc.subject.mesh	Staphylococcus aureus	en_US
dc.subject.mesh	Calcium Phosphates	en_US
dc.subject.mesh	Hydroxyapatites	en_US
dc.subject.mesh	Polymers	en_US
dc.subject.mesh	Gentamicins	en_US
dc.subject.mesh	Ceramics	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Microscopy, Electron, Scanning	en_US
dc.subject.mesh	Drug Delivery Systems	en_US
dc.subject.mesh	Microbial Sensitivity Tests	en_US
dc.subject.mesh	Tensile Strength	en_US
dc.title	Marine structure derived calcium phosphate-polymer biocomposites for local antibiotic delivery	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	13	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	0306 Physical Chemistry (incl. Structural)	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	13	en_US

Abstract:

© 2015 by the authors. Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca2+ for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against Staphylococcus aureus (S. aureus) (SH1000) even at high concentration of bacteria. The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release. Clinical release profiles can be easily tuned from drug-HAp physicochemical interactions and degradation kinetics of polymer matrix. The developed systems could be applied to prevent microbial adhesion to medical implant surfaces and to treat infections mainly caused by S. aureus in surgery.

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http://hdl.handle.net/10453/33027