Abnormal patterns of theta frequency oscillations during the temporal evolution of freezing of gait in parkinson's disease

Shine, JM; Handojoseno, AMA; Nguyen, TN; Tran, Y; Naismith, SL; Nguyen, H; Lewis, SJG

Abnormal patterns of theta frequency oscillations during the temporal evolution of freezing of gait in parkinson's disease

Shine, JM Handojoseno, AMA Nguyen, TN Tran, Y

Naismith, SL Nguyen, H

Lewis, SJG

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Publication Type:: Journal Article
Citation:: Clinical Neurophysiology, 2014, 125 (3), pp. 569 - 576
Issue Date:: 2014-03-01

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Field	Value	Language
dc.contributor.author	Shine, JM	en_US
dc.contributor.author	Handojoseno, AMA	en_US
dc.contributor.author	Nguyen, TN	en_US
dc.contributor.author	Tran, Y https://orcid.org/0000-0002-1741-4205	en_US
dc.contributor.author	Naismith, SL	en_US
dc.contributor.author	Nguyen, H https://orcid.org/0000-0003-3373-8178	en_US
dc.contributor.author	Lewis, SJG	en_US
dc.date.available	2013-09-11	en_US
dc.date.issued	2014-03-01	en_US
dc.identifier.citation	Clinical Neurophysiology, 2014, 125 (3), pp. 569 - 576	en_US
dc.identifier.issn	1388-2457	en_US
dc.identifier.uri	http://hdl.handle.net/10453/33310
dc.description.abstract	Objective: We sought to characterize the electrophysiological signature of Freezing of gait in Parkinson's disease. Methods: We examined 24 patients with idiopathic Parkinson's disease and significant freezing of gait as they performed a series of timed up-and-go tasks in their 'off' state while electroencephalographic data was collected from four scalp leads. Fast Fourier Transformation was utilized to explore the power spectral density between periods of normal walking and periods of freezing, as well as during the transition between the two states. In addition, Cross Spectrum and Cross Frequency analyses were used to explore the role of impaired temporal and spatial connectivity. Results: When compared to walking, episodes of freezing were associated with a significant increase in theta band power within the central and frontal leads. The transition from normal walking to freezing of gait was also associated with increased theta frequency coupling between the central and frontal leads, along with an increase in cross-frequency coupling in the central lead. Conclusions: Episodes of freezing of gait in Parkinson's disease are associated with abnormal oscillatory activity in the brain. Significance: These results provide novel insights into the pattern of spatiotemporal dynamics underlying freezing of gait and may provide a potential means for therapeutic prediction and alleviation of freezing episodes in susceptible patients. © 2013.	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1062319
dc.relation.ispartof	Clinical Neurophysiology	en_US
dc.relation.isbasedon	10.1016/j.clinph.2013.09.006	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.subject.mesh	Temporal Lobe	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Parkinson Disease	en_US
dc.subject.mesh	Gait Disorders, Neurologic	en_US
dc.subject.mesh	Theta Rhythm	en_US
dc.subject.mesh	Gait	en_US
dc.subject.mesh	Walking	en_US
dc.subject.mesh	Fourier Analysis	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Aged, 80 and over	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Abnormal patterns of theta frequency oscillations during the temporal evolution of freezing of gait in parkinson's disease	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	125	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	111703 Care for Disabled	en_US
utslib.for	09 Engineering	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	17 Psychology and Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	125	en_US

Abstract:

Objective: We sought to characterize the electrophysiological signature of Freezing of gait in Parkinson's disease. Methods: We examined 24 patients with idiopathic Parkinson's disease and significant freezing of gait as they performed a series of timed up-and-go tasks in their 'off' state while electroencephalographic data was collected from four scalp leads. Fast Fourier Transformation was utilized to explore the power spectral density between periods of normal walking and periods of freezing, as well as during the transition between the two states. In addition, Cross Spectrum and Cross Frequency analyses were used to explore the role of impaired temporal and spatial connectivity. Results: When compared to walking, episodes of freezing were associated with a significant increase in theta band power within the central and frontal leads. The transition from normal walking to freezing of gait was also associated with increased theta frequency coupling between the central and frontal leads, along with an increase in cross-frequency coupling in the central lead. Conclusions: Episodes of freezing of gait in Parkinson's disease are associated with abnormal oscillatory activity in the brain. Significance: These results provide novel insights into the pattern of spatiotemporal dynamics underlying freezing of gait and may provide a potential means for therapeutic prediction and alleviation of freezing episodes in susceptible patients. © 2013.

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http://hdl.handle.net/10453/33310