Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes

Seshadri, R; Myers, GSA; Tettelin, H; Eisen, JA; Heidelberg, JF; Dodson, RJ; Davidsen, TM; DeBoy, RT; Fouts, DE; Haft, DH; Selengut, J; Ren, Q; Brinkac, LM; Madupu, R; Kolonay, J; Durkin, SA; Daugherty, SC; Shetty, J; Shvartsbeyn, A; Gebregeorgis, E; Geer, K; Tsegaye, G; Malek, J; Ayodeji, B; Shatsman, S; McLeod, MP; Šmajs, D; Howell, JK; Pal, S; Amin, A; Vashisth, P; McNeill, TZ; Xiang, Q; Sodergren, E; Baca, E; Weinstock, GM; Norris, SJ; Fraser, CM; Paulsen, IT

Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes

Seshadri, R Myers, GSA

Tettelin, H Eisen, JA Heidelberg, JF Dodson, RJ Davidsen, TM DeBoy, RT Fouts, DE Haft, DH Selengut, J Ren, Q Brinkac, LM Madupu, R Kolonay, J Durkin, SA Daugherty, SC Shetty, J Shvartsbeyn, A Gebregeorgis, E Geer, K Tsegaye, G Malek, J Ayodeji, B Shatsman, S McLeod, MP Šmajs, D Howell, JK Pal, S Amin, A Vashisth, P McNeill, TZ Xiang, Q Sodergren, E Baca, E Weinstock, GM Norris, SJ Fraser, CM Paulsen, IT

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Publication Type:: Journal Article
Citation:: Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (15), pp. 5646 - 5651
Issue Date:: 2004-04-13

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Field	Value	Language
dc.contributor.author	Seshadri, R	en_US
dc.contributor.author	Myers, GSA https://orcid.org/0000-0002-4756-4810	en_US
dc.contributor.author	Tettelin, H	en_US
dc.contributor.author	Eisen, JA	en_US
dc.contributor.author	Heidelberg, JF	en_US
dc.contributor.author	Dodson, RJ	en_US
dc.contributor.author	Davidsen, TM	en_US
dc.contributor.author	DeBoy, RT	en_US
dc.contributor.author	Fouts, DE	en_US
dc.contributor.author	Haft, DH	en_US
dc.contributor.author	Selengut, J	en_US
dc.contributor.author	Ren, Q	en_US
dc.contributor.author	Brinkac, LM	en_US
dc.contributor.author	Madupu, R	en_US
dc.contributor.author	Kolonay, J	en_US
dc.contributor.author	Durkin, SA	en_US
dc.contributor.author	Daugherty, SC	en_US
dc.contributor.author	Shetty, J	en_US
dc.contributor.author	Shvartsbeyn, A	en_US
dc.contributor.author	Gebregeorgis, E	en_US
dc.contributor.author	Geer, K	en_US
dc.contributor.author	Tsegaye, G	en_US
dc.contributor.author	Malek, J	en_US
dc.contributor.author	Ayodeji, B	en_US
dc.contributor.author	Shatsman, S	en_US
dc.contributor.author	McLeod, MP	en_US
dc.contributor.author	Šmajs, D	en_US
dc.contributor.author	Howell, JK	en_US
dc.contributor.author	Pal, S	en_US
dc.contributor.author	Amin, A	en_US
dc.contributor.author	Vashisth, P	en_US
dc.contributor.author	McNeill, TZ	en_US
dc.contributor.author	Xiang, Q	en_US
dc.contributor.author	Sodergren, E	en_US
dc.contributor.author	Baca, E	en_US
dc.contributor.author	Weinstock, GM	en_US
dc.contributor.author	Norris, SJ	en_US
dc.contributor.author	Fraser, CM	en_US
dc.contributor.author	Paulsen, IT	en_US
dc.date.issued	2004-04-13	en_US
dc.identifier.citation	Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (15), pp. 5646 - 5651	en_US
dc.identifier.issn	0027-8424	en_US
dc.identifier.uri	http://hdl.handle.net/10453/39765
dc.description.abstract	We present the complete 2,843,201-bp genome sequence of Treponema denticola (ATCC 35405) an oral spirochete associated with periodontal disease. Analysis of the T. denticola genome reveals factors mediating coaggregation, cell signaling, stress protection, and other competitive and cooperative measures, consistent with its pathogenic nature and lifestyle within the mixed-species environment of subgingival dental plaque. Comparisons with previously sequenced spirochete genomes revealed specific factors contributing to differences and similarities in spirochete physiology as well as pathogenic potential. The T. denticola genome is considerably larger in size than the genome of the related syphilis-causing spirochete Treponema pallidum. The differences in gene content appear to be attributable to a combination of three phenomena: genome reduction, lineage-specific expansions, and horizontal gene transfer. Genes lost due to reductive evolution appear to be largely involved in metabolism and transport, whereas some of the genes that have arisen due to lineage-specific expansions are implicated in various pathogenic interactions, and genes acquired via horizontal gene transfer are largely phage-related or of unknown function.	en_US
dc.relation.ispartof	Proceedings of the National Academy of Sciences of the United States of America	en_US
dc.relation.isbasedon	10.1073/pnas.0307639101	en_US
dc.subject.mesh	Mouth	en_US
dc.subject.mesh	Leptospira interrogans	en_US
dc.subject.mesh	Borrelia burgdorferi	en_US
dc.subject.mesh	Treponema	en_US
dc.subject.mesh	Treponema pallidum	en_US
dc.subject.mesh	Bacterial Proteins	en_US
dc.subject.mesh	ATP-Binding Cassette Transporters	en_US
dc.subject.mesh	Base Sequence	en_US
dc.subject.mesh	Sequence Homology, Amino Acid	en_US
dc.subject.mesh	Genes, Bacterial	en_US
dc.subject.mesh	Genome, Bacterial	en_US
dc.subject.mesh	Models, Genetic	en_US
dc.subject.mesh	Molecular Sequence Data	en_US
dc.title	Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes	en_US
dc.type	Journal Article
utslib.citation.volume	15	en_US
utslib.citation.volume	101	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	15	en_US
pubs.publication-status	Published	en_US
pubs.volume	101	en_US

Abstract:

We present the complete 2,843,201-bp genome sequence of Treponema denticola (ATCC 35405) an oral spirochete associated with periodontal disease. Analysis of the T. denticola genome reveals factors mediating coaggregation, cell signaling, stress protection, and other competitive and cooperative measures, consistent with its pathogenic nature and lifestyle within the mixed-species environment of subgingival dental plaque. Comparisons with previously sequenced spirochete genomes revealed specific factors contributing to differences and similarities in spirochete physiology as well as pathogenic potential. The T. denticola genome is considerably larger in size than the genome of the related syphilis-causing spirochete Treponema pallidum. The differences in gene content appear to be attributable to a combination of three phenomena: genome reduction, lineage-specific expansions, and horizontal gene transfer. Genes lost due to reductive evolution appear to be largely involved in metabolism and transport, whereas some of the genes that have arisen due to lineage-specific expansions are implicated in various pathogenic interactions, and genes acquired via horizontal gene transfer are largely phage-related or of unknown function.

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http://hdl.handle.net/10453/39765