RNA Binding Proteins in the miRNA pathway

Connerty, P; Ahadi, A; Hutvagner, G

RNA Binding Proteins in the miRNA pathway

Connerty, P Ahadi, A

Hutvagner, G

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Publication Type:: Journal Article
Citation:: International Journal of Molecular Sciences, 2015, 17 (1)
Issue Date:: 2015-12-26

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Field	Value	Language
dc.contributor.author	Connerty, P	en_US
dc.contributor.author	Ahadi, A https://orcid.org/0000-0002-2018-3065	en_US
dc.contributor.author	Hutvagner, G https://orcid.org/0000-0002-7231-9446	en_US
dc.date.available	2015-12-23	en_US
dc.date.issued	2015-12-26	en_US
dc.identifier.citation	International Journal of Molecular Sciences, 2015, 17 (1)	en_US
dc.identifier.issn	1661-6596	en_US
dc.identifier.uri	http://hdl.handle.net/10453/41086
dc.description.abstract	© 2015 by the authors; licensee MDPI, Basel, Switzerland. microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs). We also describe multiple mechanisms that regulate the canonical miRNA pathway, which depends on a wide range of RBPs. Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets.	en_US
dc.relation.ispartof	International Journal of Molecular Sciences	en_US
dc.relation.isbasedon	10.3390/ijms17010031	en_US
dc.subject.classification	Chemical Physics	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Ribonuclease III	en_US
dc.subject.mesh	MicroRNAs	en_US
dc.subject.mesh	Gene Silencing	en_US
dc.subject.mesh	Protein Binding	en_US
dc.subject.mesh	Argonaute Proteins	en_US
dc.title	RNA Binding Proteins in the miRNA pathway	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	17	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	0604 Genetics	en_US
utslib.for	0399 Other Chemical Sciences	en_US
utslib.for	0699 Other Biological Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Computer Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	17	en_US

Abstract:

© 2015 by the authors; licensee MDPI, Basel, Switzerland. microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs). We also describe multiple mechanisms that regulate the canonical miRNA pathway, which depends on a wide range of RBPs. Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets.

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http://hdl.handle.net/10453/41086