In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146

Ong, VA; Lawrence, A; Timms, P; Vodstrcil, LA; Tabrizi, SN; Beagley, KW; Allan, JA; Hocking, JS; Huston, WM

In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146

Ong, VA Lawrence, A Timms, P Vodstrcil, LA Tabrizi, SN Beagley, KW Allan, JA Hocking, JS Huston, WM

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Publication Type:: Journal Article
Citation:: Microbes and Infection, 2015, 17 (11-12), pp. 738 - 744
Issue Date:: 2015-11-01

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Field	Value	Language
dc.contributor.author	Ong, VA	en_US
dc.contributor.author	Lawrence, A	en_US
dc.contributor.author	Timms, P	en_US
dc.contributor.author	Vodstrcil, LA	en_US
dc.contributor.author	Tabrizi, SN	en_US
dc.contributor.author	Beagley, KW	en_US
dc.contributor.author	Allan, JA	en_US
dc.contributor.author	Hocking, JS	en_US
dc.contributor.author	Huston, WM https://orcid.org/0000-0002-0879-1287	en_US
dc.date.available	2020-05-25T19:18:17Z
dc.date.issued	2015-11-01	en_US
dc.identifier.citation	Microbes and Infection, 2015, 17 (11-12), pp. 738 - 744	en_US
dc.identifier.issn	1286-4579	en_US
dc.identifier.uri	http://hdl.handle.net/10453/41117
dc.description.abstract	© 2015 Institut Pasteur. The present study aimed to establish if a previously identified Chlamydia trachomatis HtrA (CtHtrA) inhibitor, JO146, is effective against currently circulating clinical isolates to validate if CtHtrA is a clinically relevant target for future therapeutic development. Inhibition of CtHtrA during the middle of the chlamydial replicative cycle until the completion of the cycle resulted in loss of infectious progeny for six unique clinical isolates representing different serovars. This supports the potential for CtHtrA to be a clinically relevant target for development of new therapeutics and suggests the importance of further investigation of JO146 as a lead compound.	en_US
dc.relation.ispartof	Microbes and Infection	en_US
dc.relation.isbasedon	10.1016/j.micinf.2015.09.004	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Cell Line	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Chlamydia trachomatis	en_US
dc.subject.mesh	Serine Endopeptidases	en_US
dc.subject.mesh	Dipeptides	en_US
dc.subject.mesh	Serine Proteinase Inhibitors	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Organophosphonates	en_US
dc.title	In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146	en_US
dc.type	Journal Article
utslib.citation.volume	11-12	en_US
utslib.citation.volume	17	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1107 Immunology	en_US
utslib.for	1108 Medical Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access
pubs.issue	11-12	en_US
pubs.publication-status	Published	en_US
pubs.volume	17	en_US

Abstract:

© 2015 Institut Pasteur. The present study aimed to establish if a previously identified Chlamydia trachomatis HtrA (CtHtrA) inhibitor, JO146, is effective against currently circulating clinical isolates to validate if CtHtrA is a clinically relevant target for future therapeutic development. Inhibition of CtHtrA during the middle of the chlamydial replicative cycle until the completion of the cycle resulted in loss of infectious progeny for six unique clinical isolates representing different serovars. This supports the potential for CtHtrA to be a clinically relevant target for development of new therapeutics and suggests the importance of further investigation of JO146 as a lead compound.

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http://hdl.handle.net/10453/41117