VEGF<inf>111</inf>: New insights in tissue invasion

Danastas, K; Combes, V; Lindsay, LA; Grau, GER; Thompson, MB; Murphy, CR

VEGF<inf>111</inf>: New insights in tissue invasion

Danastas, K Combes, V

Lindsay, LA Grau, GER Thompson, MB Murphy, CR

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Publication Type:: Journal Article
Citation:: Frontiers in Physiology, 2015, 6 (JAN)
Issue Date:: 2015-01-01

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Field	Value	Language
dc.contributor.author	Danastas, K	en_US
dc.contributor.author	Combes, V https://orcid.org/0000-0003-2178-3596	en_US
dc.contributor.author	Lindsay, LA	en_US
dc.contributor.author	Grau, GER	en_US
dc.contributor.author	Thompson, MB	en_US
dc.contributor.author	Murphy, CR	en_US
dc.date.available	2015-01-05	en_US
dc.date.issued	2015-01-01	en_US
dc.identifier.citation	Frontiers in Physiology, 2015, 6 (JAN)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/41483
dc.description.abstract	© 2015 Danastas, Combes, Lindsay, Grau, Thompson and Murphy. Vascular endothelial growth factor is a secreted glycoprotein that acts on endothelial cells to induce developmental and physiological angiogenesis. It has also been implicated in angiogenesis occurring in several pathologies, most notably, cancer. Alternative splicing of VEGF mRNA transcripts results in several isoforms with distinct properties depending on their exon composition. Recently, a new isoform has been identified, VEGF111 with a unique exon composition responsible for its high angiogenic potential. In humans, the only known inducer of VEGF111 is DNA damage but its natural presence in the uterus of the viviparous lizard, Saiphos equalis, suggests other mechanisms of regulation. Most interestingly, the possible relationship between the evolution of viviparity and the associated increased risk in developing cancer may be important in understanding the mechanisms underlying tumor development.	en_US
dc.relation.ispartof	Frontiers in Physiology	en_US
dc.relation.isbasedon	10.3389/fphys.2015.00002	en_US
dc.title	VEGF<inf>111</inf>: New insights in tissue invasion	en_US
dc.type	Journal Article
utslib.citation.volume	JAN	en_US
utslib.citation.volume	6	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	0606 Physiology	en_US
utslib.for	1116 Medical Physiology	en_US
utslib.for	1701 Psychology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access
pubs.issue	JAN	en_US
pubs.publication-status	Published	en_US
pubs.volume	6	en_US

Abstract:

© 2015 Danastas, Combes, Lindsay, Grau, Thompson and Murphy. Vascular endothelial growth factor is a secreted glycoprotein that acts on endothelial cells to induce developmental and physiological angiogenesis. It has also been implicated in angiogenesis occurring in several pathologies, most notably, cancer. Alternative splicing of VEGF mRNA transcripts results in several isoforms with distinct properties depending on their exon composition. Recently, a new isoform has been identified, VEGF111 with a unique exon composition responsible for its high angiogenic potential. In humans, the only known inducer of VEGF111 is DNA damage but its natural presence in the uterus of the viviparous lizard, Saiphos equalis, suggests other mechanisms of regulation. Most interestingly, the possible relationship between the evolution of viviparity and the associated increased risk in developing cancer may be important in understanding the mechanisms underlying tumor development.

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http://hdl.handle.net/10453/41483