Increased incidence of gestational hypertension and preeclampsia after assisted reproductive technology treatment

Wang, YA; Chughtai, AA; Farquhar, CM; Pollock, W; Lui, K; Sullivan, EA

Increased incidence of gestational hypertension and preeclampsia after assisted reproductive technology treatment

Wang, YA

Chughtai, AA Farquhar, CM Pollock, W Lui, K Sullivan, EA

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Publication Type:: Journal Article
Citation:: Fertility and Sterility, 2016, 105 (4), pp. 920 - 926.e2
Issue Date:: 2016-04-01

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Field	Value	Language
dc.contributor.author	Wang, YA https://orcid.org/0000-0002-3656-4284	en_US
dc.contributor.author	Chughtai, AA	en_US
dc.contributor.author	Farquhar, CM	en_US
dc.contributor.author	Pollock, W	en_US
dc.contributor.author	Lui, K	en_US
dc.contributor.author	Sullivan, EA https://orcid.org/0000-0002-8718-2753	en_US
dc.date.available	2020-05-25T19:04:34Z
dc.date.issued	2016-04-01	en_US
dc.identifier.citation	Fertility and Sterility, 2016, 105 (4), pp. 920 - 926.e2	en_US
dc.identifier.issn	0015-0282	en_US
dc.identifier.uri	http://hdl.handle.net/10453/41900
dc.description.abstract	© 2016 American Society for Reproductive Medicine. Objective To determine the association between assisted reproductive technology (ART) treatment and the rate of combined gestational hypertension (GH), preeclampsia (PE). Design Retrospective population study. Setting Not applicable. Patient(s) A total of 596,520 mothers (3.6% ART mothers) who gave birth between 2007 and 2011. Intervention(s) Not applicable. Main Outcome Measure(s) Comparison of the rate of GH/PE for ART and non-ART mothers, with odds ratio (OR), adjusted odds ratio (AOR), and 95% confidence interval (CI) used to assess the association between ART and GH/PE. Result(s) The overall rate of GH/PE was 4.3%, with 6.4% for ART mothers and 4.3% for non-ART mothers. The rate of GH/PE was higher for mothers of twins than singletons (12.4% vs. 5.7% for ART mothers; 8.6% vs. 4.2% for non-ART mothers). The ART mothers had a 17% increased odds of GH/PE compared with the non-ART mothers (AOR 1.17; 95% CI, 1.10-1.24). After stratification by plurality, the difference in GH/PE rates between ART and non-ART mothers was not statistically significant, with AOR 1.05 (95% CI, 0.98-1.12) for mothers of singletons and AOR 1.10 (95% CI, 0.94-1.30) for mothers of twins. Conclusion(s) The changes in AOR after stratification indicated that multiple pregnancies after ART are the single most likely explanation for the increased rate of GH/PE among ART mothers. The lower rate of GH/PE among mothers of singletons compared with mothers of twins suggests that a policy to minimize multiple pregnancies after ART may reduce the excess risk of GH/PE due to ART treatment.	en_US
dc.relation.ispartof	Fertility and Sterility	en_US
dc.relation.isbasedon	10.1016/j.fertnstert.2015.12.024	en_US
dc.subject.classification	Obstetrics & Reproductive Medicine	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Hypertension, Pregnancy-Induced	en_US
dc.subject.mesh	Pre-Eclampsia	en_US
dc.subject.mesh	Treatment Outcome	en_US
dc.subject.mesh	Reproductive Techniques, Assisted	en_US
dc.subject.mesh	Population Surveillance	en_US
dc.subject.mesh	Incidence	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Retrospective Studies	en_US
dc.subject.mesh	Cohort Studies	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Pregnancy, Multiple	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Female	en_US
dc.title	Increased incidence of gestational hypertension and preeclampsia after assisted reproductive technology treatment	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	105	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1117 Public Health and Health Services	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
utslib.copyright.status	open_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	105	en_US

Abstract:

© 2016 American Society for Reproductive Medicine. Objective To determine the association between assisted reproductive technology (ART) treatment and the rate of combined gestational hypertension (GH), preeclampsia (PE). Design Retrospective population study. Setting Not applicable. Patient(s) A total of 596,520 mothers (3.6% ART mothers) who gave birth between 2007 and 2011. Intervention(s) Not applicable. Main Outcome Measure(s) Comparison of the rate of GH/PE for ART and non-ART mothers, with odds ratio (OR), adjusted odds ratio (AOR), and 95% confidence interval (CI) used to assess the association between ART and GH/PE. Result(s) The overall rate of GH/PE was 4.3%, with 6.4% for ART mothers and 4.3% for non-ART mothers. The rate of GH/PE was higher for mothers of twins than singletons (12.4% vs. 5.7% for ART mothers; 8.6% vs. 4.2% for non-ART mothers). The ART mothers had a 17% increased odds of GH/PE compared with the non-ART mothers (AOR 1.17; 95% CI, 1.10-1.24). After stratification by plurality, the difference in GH/PE rates between ART and non-ART mothers was not statistically significant, with AOR 1.05 (95% CI, 0.98-1.12) for mothers of singletons and AOR 1.10 (95% CI, 0.94-1.30) for mothers of twins. Conclusion(s) The changes in AOR after stratification indicated that multiple pregnancies after ART are the single most likely explanation for the increased rate of GH/PE among ART mothers. The lower rate of GH/PE among mothers of singletons compared with mothers of twins suggests that a policy to minimize multiple pregnancies after ART may reduce the excess risk of GH/PE due to ART treatment.

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http://hdl.handle.net/10453/41900