Analysis of ecstasy tablets using capillary electrophoresis with capacitively coupled contactless conductivity detection

Porto, SKSS; Nogueira, T; Blanes, L; Doble, P; Sabino, BD; do Lago, CL; Angnes, L

Analysis of ecstasy tablets using capillary electrophoresis with capacitively coupled contactless conductivity detection

Porto, SKSS Nogueira, T Blanes, L Doble, P

Sabino, BD do Lago, CL Angnes, L

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Publication Type:: Journal Article
Citation:: Journal of Forensic Sciences, 2014, 59 (6), pp. 1622 - 1626
Issue Date:: 2014-01-01

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Field	Value	Language
dc.contributor.author	Porto, SKSS	en_US
dc.contributor.author	Nogueira, T	en_US
dc.contributor.author	Blanes, L	en_US
dc.contributor.author	Doble, P https://orcid.org/0000-0002-8472-1301	en_US
dc.contributor.author	Sabino, BD	en_US
dc.contributor.author	do Lago, CL	en_US
dc.contributor.author	Angnes, L	en_US
dc.date.available	2013-12-01	en_US
dc.date.issued	2014-01-01	en_US
dc.identifier.citation	Journal of Forensic Sciences, 2014, 59 (6), pp. 1622 - 1626	en_US
dc.identifier.issn	0022-1198	en_US
dc.identifier.uri	http://hdl.handle.net/10453/51620
dc.description.abstract	© 2014 American Academy of Forensic Sciences. A method for the identification of 3,4-methylenedioxymethamphetamine (MDMA) and meta-chlorophenylpiperazine (mCPP) was developed employing capillary electrophoresis (CE) with capacitively coupled contactless conductivity detection (C4D). Sample extraction, separation, and detection of "Ecstasy" tablets were performed in <10 min without sample derivatization. The separation electrolyte was 20 mm TAPS/Lithium, pH 8.7. Average minimal detectable amounts for MDMA and mCPP were 0.04 mg/tablet, several orders of magnitude lower than the minimum amount encountered in a tablet. Seven different Ecstasy tablets seized in Rio de Janeiro, Brazil, were analyzed by CE-C4D and compared against routine gas chromatography-mass spectrometry (GC-MS). The CE method demonstrated sufficient selectivity to discriminate the two target drugs, MDMA and mCPP, from the other drugs present in seizures, namely amphepramone, fenproporex, caffeine, lidocaine, and cocaine. Separation was performed in <90 sec. The advantages of using C4D instead of traditional CE-UV methods for in-field analysis are also discussed.	en_US
dc.relation	http://purl.org/au-research/grants/arc/LP120200079
dc.relation.ispartof	Journal of Forensic Sciences	en_US
dc.relation.isbasedon	10.1111/1556-4029.12573	en_US
dc.subject.classification	Legal & Forensic Medicine	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Sulfonic Acids	en_US
dc.subject.mesh	Lithium Compounds	en_US
dc.subject.mesh	N-Methyl-3,4-methylenedioxyamphetamine	en_US
dc.subject.mesh	Acetic Acid	en_US
dc.subject.mesh	Piperazines	en_US
dc.subject.mesh	Hallucinogens	en_US
dc.subject.mesh	Tablets	en_US
dc.subject.mesh	Electrophoresis, Capillary	en_US
dc.subject.mesh	Electric Conductivity	en_US
dc.subject.mesh	Gas Chromatography-Mass Spectrometry	en_US
dc.subject.mesh	Serotonin Receptor Agonists	en_US
dc.subject.mesh	Drug Trafficking	en_US
dc.title	Analysis of ecstasy tablets using capillary electrophoresis with capacitively coupled contactless conductivity detection	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	59	en_US
utslib.for	0399 Other Chemical Sciences	en_US
utslib.for	0699 Other Biological Sciences	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	closed_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	59	en_US

Abstract:

© 2014 American Academy of Forensic Sciences. A method for the identification of 3,4-methylenedioxymethamphetamine (MDMA) and meta-chlorophenylpiperazine (mCPP) was developed employing capillary electrophoresis (CE) with capacitively coupled contactless conductivity detection (C4D). Sample extraction, separation, and detection of "Ecstasy" tablets were performed in <10 min without sample derivatization. The separation electrolyte was 20 mm TAPS/Lithium, pH 8.7. Average minimal detectable amounts for MDMA and mCPP were 0.04 mg/tablet, several orders of magnitude lower than the minimum amount encountered in a tablet. Seven different Ecstasy tablets seized in Rio de Janeiro, Brazil, were analyzed by CE-C4D and compared against routine gas chromatography-mass spectrometry (GC-MS). The CE method demonstrated sufficient selectivity to discriminate the two target drugs, MDMA and mCPP, from the other drugs present in seizures, namely amphepramone, fenproporex, caffeine, lidocaine, and cocaine. Separation was performed in <90 sec. The advantages of using C4D instead of traditional CE-UV methods for in-field analysis are also discussed.

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http://hdl.handle.net/10453/51620