Assessment of multiple hormone activities of a UV-filter (octocrylene) in zebrafish (Danio rerio)

Zhang, QY; Ma, XY; Wang, XC; Ngo, HH

Assessment of multiple hormone activities of a UV-filter (octocrylene) in zebrafish (Danio rerio)

Zhang, QY Ma, XY Wang, XC Ngo, HH

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Publication Type:: Journal Article
Citation:: Chemosphere, 2016, 159 pp. 433 - 441
Issue Date:: 2016-09-01

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Field	Value	Language
dc.contributor.author	Zhang, QY	en_US
dc.contributor.author	Ma, XY	en_US
dc.contributor.author	Wang, XC	en_US
dc.contributor.author	Ngo, HH https://orcid.org/0000-0002-0296-2866	en_US
dc.date.available	2020-05-25T19:20:19Z
dc.date.issued	2016-09-01	en_US
dc.identifier.citation	Chemosphere, 2016, 159 pp. 433 - 441	en_US
dc.identifier.issn	0045-6535	en_US
dc.identifier.uri	http://hdl.handle.net/10453/61389
dc.description.abstract	© 2016 Elsevier Ltd In this study, zebrafish (Danio rerio) were exposed to a UV-filter-octocrylene (OCT) with elevated concentrations for 28 d. The total body accumulation of OCT in zebrafish was found to reach 2321.01 (“L” level), 31,234.80 (“M” level), and 70,593.38 ng g−1 (“H” level) when the average OCT exposure concentration was controlled at 28.61, 505.62, and 1248.70 μg L−1, respectively. Gross and histological observations as well as RT-qPCR analysis were conducted to determine the effects of OCT accumulation on zebrafish. After exposure, the gonad-somatic index and percentage of vitellogenic oocytes were found to increase significantly in the ovaries of female zebrafish at the H accumulation level. Significant up-regulation of esr1 and cyp19b were observed in the gonads, as well as vtg1 in the livers for both female and male zebrafish. At M and H accumulation levels, apparent down-regulation of ar was observed in the ovaries and testis of the female and male zebrafish, respectively. Although the extent of the effects on zebrafish differed at different accumulation levels, the induction of vtg1 and histological changes in the ovaries are indications of estrogenic activity and the inhibition of esr1 and ar showed antiestrogenic and antiandrogenic activity, respectively. Thus, as OCT could easily accumulate in aquatic life such as zebrafish, one of its most of concern hazards would be the disturbance of the histological development and its multiple hormonal activities.	en_US
dc.relation.ispartof	Chemosphere	en_US
dc.relation.isbasedon	10.1016/j.chemosphere.2016.06.037	en_US
dc.subject.classification	Environmental Sciences	en_US
dc.subject.classification	Meteorology & Atmospheric Sciences	en_US
dc.subject.mesh	Ovary	en_US
dc.subject.mesh	Testis	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Zebrafish	en_US
dc.subject.mesh	Acrylates	en_US
dc.subject.mesh	Vitellogenins	en_US
dc.subject.mesh	Sunscreening Agents	en_US
dc.subject.mesh	Water Pollutants, Chemical	en_US
dc.subject.mesh	Gene Expression Regulation	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Assessment of multiple hormone activities of a UV-filter (octocrylene) in zebrafish (Danio rerio)	en_US
dc.type	Journal Article
utslib.citation.volume	159	en_US
utslib.for	0608 Zoology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	159	en_US

Abstract:

© 2016 Elsevier Ltd In this study, zebrafish (Danio rerio) were exposed to a UV-filter-octocrylene (OCT) with elevated concentrations for 28 d. The total body accumulation of OCT in zebrafish was found to reach 2321.01 (“L” level), 31,234.80 (“M” level), and 70,593.38 ng g−1 (“H” level) when the average OCT exposure concentration was controlled at 28.61, 505.62, and 1248.70 μg L−1, respectively. Gross and histological observations as well as RT-qPCR analysis were conducted to determine the effects of OCT accumulation on zebrafish. After exposure, the gonad-somatic index and percentage of vitellogenic oocytes were found to increase significantly in the ovaries of female zebrafish at the H accumulation level. Significant up-regulation of esr1 and cyp19b were observed in the gonads, as well as vtg1 in the livers for both female and male zebrafish. At M and H accumulation levels, apparent down-regulation of ar was observed in the ovaries and testis of the female and male zebrafish, respectively. Although the extent of the effects on zebrafish differed at different accumulation levels, the induction of vtg1 and histological changes in the ovaries are indications of estrogenic activity and the inhibition of esr1 and ar showed antiestrogenic and antiandrogenic activity, respectively. Thus, as OCT could easily accumulate in aquatic life such as zebrafish, one of its most of concern hazards would be the disturbance of the histological development and its multiple hormonal activities.

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http://hdl.handle.net/10453/61389