Widespread and Indiscriminate Nanosilver Use: Genuine Potential for Microbial Resistance

Gunawan, C; Marquis, CP; Amal, R; Sotiriou, GA; Rice, SA; Harry, EJ

Widespread and Indiscriminate Nanosilver Use: Genuine Potential for Microbial Resistance

Gunawan, C

Marquis, CP Amal, R Sotiriou, GA Rice, SA

Harry, EJ

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Publication Type:: Journal Article
Citation:: ACS Nano, 2017, 11 (4), pp. 3438 - 3445
Issue Date:: 2017-04-25

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Field	Value	Language
dc.contributor.author	Gunawan, C https://orcid.org/0000-0002-2957-1347	en_US
dc.contributor.author	Marquis, CP	en_US
dc.contributor.author	Amal, R	en_US
dc.contributor.author	Sotiriou, GA	en_US
dc.contributor.author	Rice, SA https://orcid.org/0000-0002-9486-2343	en_US
dc.contributor.author	Harry, EJ https://orcid.org/0000-0003-0858-9473	en_US
dc.date.available	2020-05-25T19:06:26Z
dc.date.issued	2017-04-25	en_US
dc.identifier.citation	ACS Nano, 2017, 11 (4), pp. 3438 - 3445	en_US
dc.identifier.issn	1936-0851	en_US
dc.identifier.uri	http://hdl.handle.net/10453/89995
dc.description.abstract	© 2017 American Chemical Society. In this era of increasing antibiotic resistance, the use of alternative antimicrobials such as silver has become more widespread. Superior antimicrobial activity has been provided through fabrication of silver nanoparticles or nanosilver (NAg), which imparts cytotoxic actions distinct from those of bulk silver. In the wake of the recent discoveries of bacterial resistance to NAg and its rising incorporation in medical and consumer goods such as wound dressings and dietary supplements, we argue that there is an urgent need to monitor the prevalence and spread of NAg microbial resistance. In this Perspective, we describe how the use of NAg in commercially available products facilitates prolonged microorganism exposure to bioavailable silver, which underpins the development of resistance. Furthermore, we advocate for a judicial approach toward NAg use in order to preserve its efficacy and to avoid environmental disruption.	en_US
dc.relation.ispartof	ACS Nano	en_US
dc.relation.isbasedon	10.1021/acsnano.7b01166	en_US
dc.subject.classification	Nanoscience & Nanotechnology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Bacteria	en_US
dc.subject.mesh	Silver	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Microbial Sensitivity Tests	en_US
dc.subject.mesh	Drug Resistance, Bacterial	en_US
dc.subject.mesh	Metal Nanoparticles	en_US
dc.title	Widespread and Indiscriminate Nanosilver Use: Genuine Potential for Microbial Resistance	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	11	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	11	en_US

Abstract:

© 2017 American Chemical Society. In this era of increasing antibiotic resistance, the use of alternative antimicrobials such as silver has become more widespread. Superior antimicrobial activity has been provided through fabrication of silver nanoparticles or nanosilver (NAg), which imparts cytotoxic actions distinct from those of bulk silver. In the wake of the recent discoveries of bacterial resistance to NAg and its rising incorporation in medical and consumer goods such as wound dressings and dietary supplements, we argue that there is an urgent need to monitor the prevalence and spread of NAg microbial resistance. In this Perspective, we describe how the use of NAg in commercially available products facilitates prolonged microorganism exposure to bioavailable silver, which underpins the development of resistance. Furthermore, we advocate for a judicial approach toward NAg use in order to preserve its efficacy and to avoid environmental disruption.

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http://hdl.handle.net/10453/89995