Non-proteinuric pre-eclampsia: A novel risk indicator in women with gestational hypertension

Homer, CSE; Brown, MA; Mangos, G; Davis, GK

Non-proteinuric pre-eclampsia: A novel risk indicator in women with gestational hypertension

Homer, CSE

Brown, MA Mangos, G Davis, GK

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Publication Type:: Journal Article
Citation:: Journal of Hypertension, 2008, 26 (2), pp. 295 - 302
Issue Date:: 2008-02-01

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Field	Value	Language
dc.contributor.author	Homer, CSE https://orcid.org/0000-0002-7454-3011	en_US
dc.contributor.author	Brown, MA	en_US
dc.contributor.author	Mangos, G	en_US
dc.contributor.author	Davis, GK	en_US
dc.date.issued	2008-02-01	en_US
dc.identifier.citation	Journal of Hypertension, 2008, 26 (2), pp. 295 - 302	en_US
dc.identifier.issn	0263-6352	en_US
dc.identifier.uri	http://hdl.handle.net/10453/9735
dc.identifier.uri	http://hdl.handle.net/10453/32267
dc.description.abstract	OBJECTIVE: To determine whether outcomes differed for women with pre-eclampsia according to the presence of proteinuria and whether non-proteinuric pre-eclampsia is similar to gestational hypertension. DESIGN: From 1987 to 2005, at three hospitals in Sydney, Australia, women referred to the obstetric medicine team were recruited. Outcomes for three groups were compared: proteinuric pre-eclampsia, non-proteinuric pre-eclampsia and gestational hypertension. RESULTS: Women with proteinuric pre-eclampsia were more likely to have severe hypertension (39 versus 30%, P = 0.003), deliver preterm infants (39 versus 30%, P = 0.007) and had a higher perinatal mortality rate (25.2 versus 5.7 per 1000, P = 0.02) than those with non-proteinuric pre-eclampsia, who were more likely to have thrombocytopenia and liver disease. Women with non-proteinuric pre-eclampsia were more likely to have multiple pregnancies (3.9 versus 9.9%, P < 0.001), experience severe hypertension (8.9 versus 29.7%, P < 0.001), and deliver preterm infants (11.3 versus 30.2%, P < 0.001) who were small for gestational age (12.7 versus 20.9%, P < 0.001) than those with gestational hypertension. CONCLUSION: This study highlights differences between non-proteinuric pre-eclampsia and gestational hypertension. The subclassification of 'non-proteinuric pre-eclampsia' should be added to existing classification systems to alert clinicians to potential risks. © 2008 Lippincott Williams & Wilkins, Inc.	en_US
dc.relation.ispartof	Journal of Hypertension	en_US
dc.relation.isbasedon	10.1097/HJH.0b013e3282f1a953	en_US
dc.subject.classification	Cardiovascular System & Hematology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Proteinuria	en_US
dc.subject.mesh	Hypertension, Pregnancy-Induced	en_US
dc.subject.mesh	Pre-Eclampsia	en_US
dc.subject.mesh	Premature Birth	en_US
dc.subject.mesh	Hypertension	en_US
dc.subject.mesh	Biological Markers	en_US
dc.subject.mesh	Odds Ratio	en_US
dc.subject.mesh	Case-Control Studies	en_US
dc.subject.mesh	Retrospective Studies	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Infant, Newborn	en_US
dc.subject.mesh	Infant, Small for Gestational Age	en_US
dc.subject.mesh	Infant, Premature	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Biomarkers	en_US
dc.title	Non-proteinuric pre-eclampsia: A novel risk indicator in women with gestational hypertension	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	26	en_US
utslib.for	111717 Primary Health Care	en_US
utslib.for	111006 Midwifery	en_US
utslib.for	1102 Cardiorespiratory Medicine and Haematology	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1116 Medical Physiology	en_US
dc.location.activity	Brisbane, AUSTRALIA
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
pubs.organisational-group	/University of Technology Sydney/Strength - WHO CC
utslib.copyright.status	open_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	26	en_US

Abstract:

OBJECTIVE: To determine whether outcomes differed for women with pre-eclampsia according to the presence of proteinuria and whether non-proteinuric pre-eclampsia is similar to gestational hypertension. DESIGN: From 1987 to 2005, at three hospitals in Sydney, Australia, women referred to the obstetric medicine team were recruited. Outcomes for three groups were compared: proteinuric pre-eclampsia, non-proteinuric pre-eclampsia and gestational hypertension. RESULTS: Women with proteinuric pre-eclampsia were more likely to have severe hypertension (39 versus 30%, P = 0.003), deliver preterm infants (39 versus 30%, P = 0.007) and had a higher perinatal mortality rate (25.2 versus 5.7 per 1000, P = 0.02) than those with non-proteinuric pre-eclampsia, who were more likely to have thrombocytopenia and liver disease. Women with non-proteinuric pre-eclampsia were more likely to have multiple pregnancies (3.9 versus 9.9%, P < 0.001), experience severe hypertension (8.9 versus 29.7%, P < 0.001), and deliver preterm infants (11.3 versus 30.2%, P < 0.001) who were small for gestational age (12.7 versus 20.9%, P < 0.001) than those with gestational hypertension. CONCLUSION: This study highlights differences between non-proteinuric pre-eclampsia and gestational hypertension. The subclassification of 'non-proteinuric pre-eclampsia' should be added to existing classification systems to alert clinicians to potential risks. © 2008 Lippincott Williams & Wilkins, Inc.

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http://hdl.handle.net/10453/9735