One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina

Gupta, V; Gupta, VB; Chitranshi, N; Gangoda, S; Vander Wall, R; Abbasi, M; Golzan, M; Dheer, Y; Shah, T; Avolio, A; Chung, R; Martins, R; Graham, S

One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina

Gupta, V Gupta, VB Chitranshi, N Gangoda, S Vander Wall, R Abbasi, M Golzan, M

Dheer, Y Shah, T Avolio, A Chung, R Martins, R Graham, S

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Publication Type:: Journal Article
Citation:: Cellular and Molecular Life Sciences, 2016, 73 (22), pp. 4279 - 4297
Issue Date:: 2016-06-22

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Field	Value	Language
dc.contributor.author	Gupta, V	en_US
dc.contributor.author	Gupta, VB	en_US
dc.contributor.author	Chitranshi, N	en_US
dc.contributor.author	Gangoda, S	en_US
dc.contributor.author	Vander Wall, R	en_US
dc.contributor.author	Abbasi, M	en_US
dc.contributor.author	Golzan, M https://orcid.org/0000-0002-4479-3917	en_US
dc.contributor.author	Dheer, Y	en_US
dc.contributor.author	Shah, T	en_US
dc.contributor.author	Avolio, A	en_US
dc.contributor.author	Chung, R	en_US
dc.contributor.author	Martins, R	en_US
dc.contributor.author	Graham, S	en_US
dc.date.available	2016-06-15	en_US
dc.date.issued	2016-06-22	en_US
dc.identifier.citation	Cellular and Molecular Life Sciences, 2016, 73 (22), pp. 4279 - 4297	en_US
dc.identifier.issn	1420-682X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/98272
dc.description.abstract	© 2016, Springer International Publishing. Accumulation of amyloid β (Aβ) and its aggregates in the ageing central nervous system is regarded synonymous to Alzheimer’s disease (AD) pathology. Despite unquestionable advances in mechanistic and diagnostic aspects of the disease understanding, the primary cause of Aβ accumulation as well as its in vivo roles remains elusive; nonetheless, the majority of the efforts to address pathological mechanisms for therapeutic development are focused towards moderating Aβ accumulation in the brain. More recently, Aβ deposition has been identified in the eye and is linked with distinct age-related diseases including age-related macular degeneration, glaucoma as well as AD. Awareness of the Aβ accumulation in these markedly different degenerative disorders has led to an increasing body of work exploring overlapping mechanisms, a prospective biomarker role for Aβ and the potential to use retina as a model for brain related neurodegenerative disorders. Here, we present an integrated view of current understanding of the retinal Aβ deposition discussing the accumulation mechanisms, anticipated impacts and outlining ameliorative approaches that can be extrapolated to the retina for potential therapeutic benefits. Further longitudinal investigations in humans and animal models will determine retinal Aβ association as a potential pathognomonic, diagnostic or prognostic biomarker.	en_US
dc.relation.ispartof	Cellular and Molecular Life Sciences	en_US
dc.relation.isbasedon	10.1007/s00018-016-2295-x	en_US
dc.subject.classification	Biochemistry & Molecular Biology	en_US
dc.subject.mesh	Brain	en_US
dc.subject.mesh	Retina	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Neurodegenerative Diseases	en_US
dc.subject.mesh	Inflammation	en_US
dc.subject.mesh	Amyloid beta-Peptides	en_US
dc.subject.mesh	Protein Aggregates	en_US
dc.title	One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina	en_US
dc.type	Journal Article
utslib.citation.volume	22	en_US
utslib.citation.volume	73	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	0606 Physiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	22	en_US
pubs.publication-status	Published	en_US
pubs.volume	73	en_US

Abstract:

© 2016, Springer International Publishing. Accumulation of amyloid β (Aβ) and its aggregates in the ageing central nervous system is regarded synonymous to Alzheimer’s disease (AD) pathology. Despite unquestionable advances in mechanistic and diagnostic aspects of the disease understanding, the primary cause of Aβ accumulation as well as its in vivo roles remains elusive; nonetheless, the majority of the efforts to address pathological mechanisms for therapeutic development are focused towards moderating Aβ accumulation in the brain. More recently, Aβ deposition has been identified in the eye and is linked with distinct age-related diseases including age-related macular degeneration, glaucoma as well as AD. Awareness of the Aβ accumulation in these markedly different degenerative disorders has led to an increasing body of work exploring overlapping mechanisms, a prospective biomarker role for Aβ and the potential to use retina as a model for brain related neurodegenerative disorders. Here, we present an integrated view of current understanding of the retinal Aβ deposition discussing the accumulation mechanisms, anticipated impacts and outlining ameliorative approaches that can be extrapolated to the retina for potential therapeutic benefits. Further longitudinal investigations in humans and animal models will determine retinal Aβ association as a potential pathognomonic, diagnostic or prognostic biomarker.

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http://hdl.handle.net/10453/98272