New genetic loci link adipose and insulin biology to body fat distribution
Shungin, D
Winkler, TW
Croteau-Chonka, DC
Ferreira, T
Locke, AE
Mägi, R
Strawbridge, RJ
Pers, TH
Fischer, K
Justice, AE
Workalemahu, T
Wu, JMW
Buchkovich, ML
Heard-Costa, NL
Roman, TS
Drong, AW
Song, C
Gustafsson, S
Day, FR
Esko, T
Fall, T
Kutalik, Z
Luan, J
Randall, JC
Scherag, A
Vedantam, S
Wood, AR
Chen, J
Fehrmann, R
Karjalainen, J
Kahali, B
Liu, CT
Schmidt, EM
Absher, D
Amin, N
Anderson, D
Beekman, M
Bragg-Gresham, JL
Buyske, S
Demirkan, A
Ehret, GB
Feitosa, MF
Goel, A
Jackson, AU
Johnson, T
Kleber, ME
Kristiansson, K
Mangino, M
Leach, IM
Medina-Gomez, C
Palmer, CD
Pasko, D
Pechlivanis, S
Peters, MJ
Prokopenko, I
Stančáková, A
Sung, YJ
Tanaka, T
Teumer, A
Van Vliet-Ostaptchouk, JV
Yengo, L
Zhang, W
Albrecht, E
Ärnlöv, J
Arscott, GM
Bandinelli, S
Barrett, A
Bellis, C
Bennett, AJ
Berne, C
Blüher, M
Böhringer, S
Bonnet, F
Böttcher, Y
Bruinenberg, M
Carba, DB
Caspersen, IH
Clarke, R
Daw, EW
Deelen, J
Deelman, E
Delgado, G
Doney, AS
Eklund, N
Erdos, MR
Estrada, K
Eury, E
Friedrich, N
Garcia, ME
Giedraitis, V
Gigante, B
Go, AS
Golay, A
Grallert, H
Grammer, TB
Gräßler, J
Grewal, J
Groves, CJ
Haller, T
Hallmans, G
- Publication Type:
- Journal Article
- Citation:
- Nature, 2015, 518 (7538), pp. 187 - 196
- Issue Date:
- 2015-02-12
Closed Access
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New genetic loci link adipose and insulin biology to body fat distribution.pdf | Submitted Version | 2.23 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author |
Shungin, D |
en_US |
dc.contributor.author | Winkler, TW | en_US |
dc.contributor.author | Croteau-Chonka, DC | en_US |
dc.contributor.author | Ferreira, T | en_US |
dc.contributor.author | Locke, AE | en_US |
dc.contributor.author | Mägi, R | en_US |
dc.contributor.author |
Strawbridge, RJ |
en_US |
dc.contributor.author |
Pers, TH |
en_US |
dc.contributor.author | Fischer, K | en_US |
dc.contributor.author | Justice, AE | en_US |
dc.contributor.author |
Workalemahu, T |
en_US |
dc.contributor.author | Wu, JMW | en_US |
dc.contributor.author | Buchkovich, ML | en_US |
dc.contributor.author |
Heard-Costa, NL |
en_US |
dc.contributor.author | Roman, TS | en_US |
dc.contributor.author | Drong, AW | en_US |
dc.contributor.author |
Song, C |
en_US |
dc.contributor.author | Gustafsson, S | en_US |
dc.contributor.author |
Day, FR |
en_US |
dc.contributor.author |
Esko, T |
en_US |
dc.contributor.author | Fall, T | en_US |
dc.contributor.author | Kutalik, Z | en_US |
dc.contributor.author | Luan, J | en_US |
dc.contributor.author |
Randall, JC |
en_US |
dc.contributor.author | Scherag, A | en_US |
dc.contributor.author | Vedantam, S | en_US |
dc.contributor.author | Wood, AR | en_US |
dc.contributor.author | Chen, J | en_US |
dc.contributor.author |
Fehrmann, R |
en_US |
dc.contributor.author | Karjalainen, J | en_US |
dc.contributor.author | Kahali, B | en_US |
dc.contributor.author | Liu, CT | en_US |
dc.contributor.author |
Schmidt, EM |
en_US |
dc.contributor.author | Absher, D | en_US |
dc.contributor.author |
Amin, N |
en_US |
dc.contributor.author |
Anderson, D |
en_US |
dc.contributor.author |
Beekman, M |
en_US |
dc.contributor.author | Bragg-Gresham, JL | en_US |
dc.contributor.author |
Buyske, S |
en_US |
dc.contributor.author | Demirkan, A | en_US |
dc.contributor.author |
Ehret, GB |
en_US |
dc.contributor.author |
Feitosa, MF |
en_US |
dc.contributor.author | Goel, A | en_US |
dc.contributor.author | Jackson, AU | en_US |
dc.contributor.author |
Johnson, T |
en_US |
dc.contributor.author |
Kleber, ME |
en_US |
dc.contributor.author |
Kristiansson, K |
en_US |
dc.contributor.author |
Mangino, M |
en_US |
dc.contributor.author | Leach, IM | en_US |
dc.contributor.author |
Medina-Gomez, C |
en_US |
dc.contributor.author | Palmer, CD | en_US |
dc.contributor.author | Pasko, D | en_US |
dc.contributor.author | Pechlivanis, S | en_US |
dc.contributor.author |
Peters, MJ |
en_US |
dc.contributor.author |
Prokopenko, I |
en_US |
dc.contributor.author | Stančáková, A | en_US |
dc.contributor.author | Sung, YJ | en_US |
dc.contributor.author | Tanaka, T | en_US |
dc.contributor.author | Teumer, A | en_US |
dc.contributor.author |
Van Vliet-Ostaptchouk, JV |
en_US |
dc.contributor.author |
Yengo, L |
en_US |
dc.contributor.author | Zhang, W | en_US |
dc.contributor.author | Albrecht, E | en_US |
dc.contributor.author | Ärnlöv, J | en_US |
dc.contributor.author | Arscott, GM | en_US |
dc.contributor.author | Bandinelli, S | en_US |
dc.contributor.author | Barrett, A | en_US |
dc.contributor.author | Bellis, C | en_US |
dc.contributor.author | Bennett, AJ | en_US |
dc.contributor.author | Berne, C | en_US |
dc.contributor.author | Blüher, M | en_US |
dc.contributor.author | Böhringer, S | en_US |
dc.contributor.author |
Bonnet, F |
en_US |
dc.contributor.author | Böttcher, Y | en_US |
dc.contributor.author | Bruinenberg, M | en_US |
dc.contributor.author | Carba, DB | en_US |
dc.contributor.author | Caspersen, IH | en_US |
dc.contributor.author | Clarke, R | en_US |
dc.contributor.author | Daw, EW | en_US |
dc.contributor.author |
Deelen, J |
en_US |
dc.contributor.author | Deelman, E | en_US |
dc.contributor.author | Delgado, G | en_US |
dc.contributor.author | Doney, AS | en_US |
dc.contributor.author | Eklund, N | en_US |
dc.contributor.author | Erdos, MR | en_US |
dc.contributor.author | Estrada, K | en_US |
dc.contributor.author | Eury, E | en_US |
dc.contributor.author | Friedrich, N | en_US |
dc.contributor.author | Garcia, ME | en_US |
dc.contributor.author | Giedraitis, V | en_US |
dc.contributor.author |
Gigante, B |
en_US |
dc.contributor.author | Go, AS | en_US |
dc.contributor.author | Golay, A | en_US |
dc.contributor.author | Grallert, H | en_US |
dc.contributor.author | Grammer, TB | en_US |
dc.contributor.author | Gräßler, J | en_US |
dc.contributor.author | Grewal, J | en_US |
dc.contributor.author | Groves, CJ | en_US |
dc.contributor.author | Haller, T | en_US |
dc.contributor.author | Hallmans, G | en_US |
dc.date.available | 2014-12-02 | en_US |
dc.date.issued | 2015-02-12 | en_US |
dc.identifier.citation | Nature, 2015, 518 (7538), pp. 187 - 196 | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | http://hdl.handle.net/10453/119113 | |
dc.description.abstract | © 2015, Macmillan Publishers Limited. All rights reserved. Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (P<5×10-8). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. | en_US |
dc.relation.ispartof | Nature | en_US |
dc.relation.isbasedon | 10.1038/nature14132 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject.classification | General Science & Technology | en_US |
dc.subject.mesh | Adipose Tissue | en_US |
dc.subject.mesh | Adipocytes | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Insulin Resistance | en_US |
dc.subject.mesh | Obesity | en_US |
dc.subject.mesh | Insulin | en_US |
dc.subject.mesh | Body Mass Index | en_US |
dc.subject.mesh | Waist-Hip Ratio | en_US |
dc.subject.mesh | Age Factors | en_US |
dc.subject.mesh | Transcription, Genetic | en_US |
dc.subject.mesh | Epigenesis, Genetic | en_US |
dc.subject.mesh | Sex Characteristics | en_US |
dc.subject.mesh | Neovascularization, Physiologic | en_US |
dc.subject.mesh | Polymorphism, Single Nucleotide | en_US |
dc.subject.mesh | Quantitative Trait Loci | en_US |
dc.subject.mesh | Genome, Human | en_US |
dc.subject.mesh | Models, Biological | en_US |
dc.subject.mesh | Continental Population Groups | en_US |
dc.subject.mesh | Europe | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Adipogenesis | en_US |
dc.subject.mesh | Body Fat Distribution | en_US |
dc.subject.mesh | Genome-Wide Association Study | en_US |
dc.title | New genetic loci link adipose and insulin biology to body fat distribution | en_US |
dc.type | Journal Article | |
utslib.citation.volume | 7538 | en_US |
utslib.citation.volume | 518 | en_US |
utslib.for | 0903 Biomedical Engineering | en_US |
utslib.for | 0604 Genetics | en_US |
pubs.embargo.period | Not known | en_US |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
utslib.copyright.status | closed_access | * |
pubs.issue | 7538 | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 518 | en_US |
Abstract:
© 2015, Macmillan Publishers Limited. All rights reserved. Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (P<5×10-8). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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