School of Biomedical Engineering

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Advancements in gene therapies targeting mutant KRAS in cancers.

Wang, Y Bui, TA Yang, X Hutvagner, G Deng, W

Mutations in the KRAS gene are well-known tumourigenic drivers of colorectal, pancreatic and lung cancers. Mechanistically, these mutations promote uncontrolled cell proliferation and alter the tum...

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3D Printing of Bioceramic Scaffolds-Barriers to the Clinical Translation: From Promise to Reality, and Future Perspectives.

Lin, K Sheikh, R Romanazzo, S Roohani, I

In this review, we summarize the challenges of the three-dimensional (3D) printing of porous bioceramics and their translational hurdles to clinical applications. The state-of-the-art of the major ...

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Design and Fabrication of 3D printed Scaffolds with a Mechanical Strength Comparable to Cortical Bone to Repair Large Bone Defects.

Roohani-Esfahani, S-I Newman, P Zreiqat, H

A challenge in regenerating large bone defects under load is to create scaffolds with large and interconnected pores while providing a compressive strength comparable to cortical bone (100-150 MPa)...

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Zirconium ions up-regulate the BMP/SMAD signaling pathway and promote the proliferation and differentiation of human osteoblasts.

Chen, Y Roohani-Esfahani, S-I Lu, Z Zreiqat, H Dunstan, CR

Zirconium (Zr) is an element commonly used in dental and orthopedic implants either as zirconia (ZrO2) or in metal alloys. It can also be incorporated into calcium silicate-based ceramics. However,...

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Effects of Sr-HT-Gahnite on osteogenesis and angiogenesis by adipose derived stem cells for critical-sized calvarial defect repair.

Wang, G Roohani-Esfahani, S-I Zhang, W Lv, K Yang, G Ding, X Zou, D Cui, D Zreiqat, H Jiang, X

Tissue engineering strategies to construct vascularized bone grafts are now attracting much attention. Strontium-hardystonite-Gahnite (Sr-HT-Gahnite) is a strong, highly porous, and biocompatible c...

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iPSC Bioprinting: Where are We at?

Romanazzo, S Nemec, S Roohani, I

Here, we present a concise review of current 3D bioprinting technologies applied to induced pluripotent stem cells (iPSC). iPSC have recently received a great deal of attention from the scientific ...

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Nature-inspired topographies on hydroxyapatite surfaces regulate stem cells behaviour.

Ramaswamy, Y Roohani, I No, YJ Madafiglio, G Chang, F Zhang, F Lu, Z Zreiqat, H

Surface topography is one of the key factors in regulating interactions between materials and cells. While topographies presented to cells in vivo are non-symmetrical and in complex shapes, current...

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Tropoelastin Improves Post-Infarct Cardiac Function.

Hume, RD Kanagalingam, S Deshmukh, T Chen, S Mithieux, SM Rashid, FN Roohani, I Lu, J Doan, T Graham, D Clayton, ZE Slaughter, E Kizana, E Stempien-Otero, AS Brown, P Thomas, L Weiss, AS Chong, JJH

BACKGROUND: Myocardial infarction (MI) is among the leading causes of death worldwide. Following MI, necrotic cardiomyocytes are replaced by a stiff collagen-rich scar. Compared to collagen, the ex...

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Antibacterial Activity and Mechanisms of Magnesium-Doped Baghdadite Bioceramics for Orthopedic Implants

Nguyen, HN Roohani, I Hayles, A Lu, Z Vongsvivut, J Vasilev, K Truong, VK Zreiqat, H

Baghdadite (BAG, Ca3ZrSi2O9), a calcium silicate compound with zirconium incorporation, shows significant potential in medical implants. However, its susceptibility to infections poses a considerab...

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Material extrusion 3D printing of bioactive smart scaffolds for bone tissue engineering

Sabahi, N Roohani, I Wang, CH Li, X

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