Biogenesis and the regulation of the maturation of miRNAs

Tran, N; Hutvagner, G

Biogenesis and the regulation of the maturation of miRNAs

Tran, N

Hutvagner, G

Permalink

Publication Type:: Journal Article
Citation:: Essays in Biochemistry, 2013, 54 (1), pp. 17 - 28
Issue Date:: 2013-06-25

Closed Access

	Filename	Description	Size
	Biogenesis_and_the_regulation_of_the_maturation_of.pdf	Published Version	569.36 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Tran, N https://orcid.org/0000-0001-7747-2530	en_US
dc.contributor.author	Hutvagner, G https://orcid.org/0000-0002-7231-9446	en_US
dc.date.issued	2013-06-25	en_US
dc.identifier.citation	Essays in Biochemistry, 2013, 54 (1), pp. 17 - 28	en_US
dc.identifier.issn	0071-1365	en_US
dc.identifier.uri	http://hdl.handle.net/10453/126888
dc.description.abstract	Regulation of gene expression is a fundamental process in both prokaryotic and eukaryotic organisms. Multiple regulatory mechanisms are in place to control gene expression at the level of transcription, post-transcription and post-translation to maintain optimal RNA and protein expressions in cells. miRNAs (micro- RNAs) are abundant short 21-23 nt non-coding RNAs that are key regulators of virtually all eukaryotic biological processes. The levels of miRNAs in an organism are crucial for proper development and sustaining optimal cell functions. Therefore the processing and regulation of the processing of these miRNAs are critical. In the present chapter we highlight the most important steps of miRNA processing, describe the functions of key proteins involved in the maturation of miRNAs, and discuss how the generation and the stability of miRNAs are regulated. © The Authors Journal compilation © 2013 Biochemical Society.	en_US
dc.relation.ispartof	Essays in Biochemistry	en_US
dc.relation.isbasedon	10.1042/BSE0540017	en_US
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Biochemistry & Molecular Biology	en_US
dc.subject.mesh	Cell Nucleus	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	MicroRNAs	en_US
dc.subject.mesh	RNA, Small Nucleolar	en_US
dc.subject.mesh	Gene Expression Regulation	en_US
dc.subject.mesh	RNA Processing, Post-Transcriptional	en_US
dc.subject.mesh	RNA Stability	en_US
dc.title	Biogenesis and the regulation of the maturation of miRNAs	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	54	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access	*
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	54	en_US

Abstract:

Regulation of gene expression is a fundamental process in both prokaryotic and eukaryotic organisms. Multiple regulatory mechanisms are in place to control gene expression at the level of transcription, post-transcription and post-translation to maintain optimal RNA and protein expressions in cells. miRNAs (micro- RNAs) are abundant short 21-23 nt non-coding RNAs that are key regulators of virtually all eukaryotic biological processes. The levels of miRNAs in an organism are crucial for proper development and sustaining optimal cell functions. Therefore the processing and regulation of the processing of these miRNAs are critical. In the present chapter we highlight the most important steps of miRNA processing, describe the functions of key proteins involved in the maturation of miRNAs, and discuss how the generation and the stability of miRNAs are regulated. © The Authors Journal compilation © 2013 Biochemical Society.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/126888