Refrigeration, cryopreservation and pathogen inactivation: an updated perspective on platelet storage conditions

Waters, L; Cameron, M; Padula, MP; Marks, DC; Johnson, L

Refrigeration, cryopreservation and pathogen inactivation: an updated perspective on platelet storage conditions

Waters, L

Cameron, M Padula, MP

Marks, DC Johnson, L

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Publication Type:: Journal Article
Citation:: Vox Sanguinis, 2018, 113 (4), pp. 317 - 328
Issue Date:: 2018-05-01

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Field	Value	Language
dc.contributor.author	Waters, L https://orcid.org/0000-0002-4740-055X	en_US
dc.contributor.author	Cameron, M	en_US
dc.contributor.author	Padula, MP https://orcid.org/0000-0002-8283-0643	en_US
dc.contributor.author	Marks, DC	en_US
dc.contributor.author	Johnson, L	en_US
dc.date.available	2020-05-25T19:03:39Z
dc.date.issued	2018-05-01	en_US
dc.identifier.citation	Vox Sanguinis, 2018, 113 (4), pp. 317 - 328	en_US
dc.identifier.issn	0042-9007	en_US
dc.identifier.uri	http://hdl.handle.net/10453/130983
dc.description.abstract	© 2018 International Society of Blood Transfusion Conventional storage of platelet concentrates limits their shelf life to between 5 and 7 days due to the risk of bacterial proliferation and the development of the platelet storage lesion. Cold storage and cryopreservation of platelets may facilitate extension of the shelf life to weeks and years, and may also provide the benefit of being more haemostatically effective than conventionally stored platelets. Further, treatment of platelet concentrates with pathogen inactivation systems reduces bacterial contamination and provides a safeguard against the risk of emerging and re-emerging pathogens. While each of these alternative storage techniques is gaining traction individually, little work has been done to examine the effect of combining treatments in an effort to further improve product safety and minimize wastage. This review aims to discuss the benefits of alternative storage techniques and how they may be combined to alleviate the problems associated with conventional platelet storage.	en_US
dc.relation.ispartof	Vox Sanguinis	en_US
dc.relation.isbasedon	10.1111/vox.12640	en_US
dc.subject.classification	Cardiovascular System & Hematology	en_US
dc.subject.mesh	Blood Platelets	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Anti-Infective Agents	en_US
dc.subject.mesh	Cryopreservation	en_US
dc.subject.mesh	Refrigeration	en_US
dc.subject.mesh	Blood Preservation	en_US
dc.title	Refrigeration, cryopreservation and pathogen inactivation: an updated perspective on platelet storage conditions	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	113	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1116 Medical Physiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	open_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	113	en_US

Abstract:

© 2018 International Society of Blood Transfusion Conventional storage of platelet concentrates limits their shelf life to between 5 and 7 days due to the risk of bacterial proliferation and the development of the platelet storage lesion. Cold storage and cryopreservation of platelets may facilitate extension of the shelf life to weeks and years, and may also provide the benefit of being more haemostatically effective than conventionally stored platelets. Further, treatment of platelet concentrates with pathogen inactivation systems reduces bacterial contamination and provides a safeguard against the risk of emerging and re-emerging pathogens. While each of these alternative storage techniques is gaining traction individually, little work has been done to examine the effect of combining treatments in an effort to further improve product safety and minimize wastage. This review aims to discuss the benefits of alternative storage techniques and how they may be combined to alleviate the problems associated with conventional platelet storage.

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http://hdl.handle.net/10453/130983