Lean mass and peak bone mineral density.

Nguyen, HG; Pham, MT; Ho-Pham, LT; Nguyen, TV

Lean mass and peak bone mineral density.

Nguyen, HG Pham, MT Ho-Pham, LT Nguyen, TV

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Osteoporosis and sarcopenia, 2020, 6, (4), pp. 212-216
Issue Date:: 2020-12

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Field	Value	Language
dc.contributor.author	Nguyen, HG
dc.contributor.author	Pham, MT
dc.contributor.author	Ho-Pham, LT
dc.contributor.author	Nguyen, TV
dc.date.accessioned	2021-02-25T19:52:53Z
dc.date.available	2020-10-28
dc.date.available	2021-02-25T19:52:53Z
dc.date.issued	2020-12
dc.identifier.citation	Osteoporosis and sarcopenia, 2020, 6, (4), pp. 212-216
dc.identifier.issn	2405-5255
dc.identifier.issn	2405-5263
dc.identifier.uri	http://hdl.handle.net/10453/146470
dc.description.abstract	<h4>Objectives</h4>The association between body composition parameters and peak bone mineral density is not well documented. The aim of this study is to assess the relative contributions of lean mass and fat mass on peak bone mineral density (BMD).<h4>Methods</h4>The study involved 416 women and 334 men aged between 20 and 30 years who were participants in the population-based Vietnam Osteoporosis Study. Whole body composition parameters (eg, fat mass and lean mass) and BMD at the lumbar spine and femoral neck were measured by dual-energy X-ray absorptiometry. The association between lean mass and fat mass and BMD was analyzed by the linear regression model using the Least Absolute Shrinkage and Selection Operator (LASSO).<h4>Results</h4>Peak BMD in men was higher than women, and the difference was more pronounced at the femoral neck (average difference: 0.123 g/cm<sup>2</sup>; 95% confidence interval [CI] 0.105-0.141 g/cm<sup>2</sup>) than at the lumbar spine (average difference 0.019 g/cm<sup>2</sup>; 95% CI, 0.005-0.036 g/cm<sup>2</sup>). Results of LASSO regression indicated that lean mass was the only predictor of BMD for either men or women. Each kilogram increase in lean mass was associated with ∼0.01 g/cm<sup>2</sup> increase in BMD. Lean mass alone explained 16% and 36% of variation in lumbar spine and femoral neck BMD, respectively.<h4>Conclusions</h4>Lean mass, not fat mass, is the main determinant of peak bone mineral density. This finding implies that good physical activity during adulthood can contribute to the maximization of peak bone mass during adulthood.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Osteoporosis and sarcopenia
dc.relation.isbasedon	10.1016/j.afos.2020.10.001
dc.rights	Elsevier required licence: © 2020 . This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The definitive publisher version is available online at https://doi.org/10.1016/j.afos.2020.10.001	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Lean mass and peak bone mineral density.
dc.type	Journal Article
utslib.citation.volume	6
utslib.location.activity	Netherlands
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
dc.date.updated	2021-02-25T19:52:49Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	6
utslib.citation.issue	4

Abstract:

Objectives

The association between body composition parameters and peak bone mineral density is not well documented. The aim of this study is to assess the relative contributions of lean mass and fat mass on peak bone mineral density (BMD).

Methods

The study involved 416 women and 334 men aged between 20 and 30 years who were participants in the population-based Vietnam Osteoporosis Study. Whole body composition parameters (eg, fat mass and lean mass) and BMD at the lumbar spine and femoral neck were measured by dual-energy X-ray absorptiometry. The association between lean mass and fat mass and BMD was analyzed by the linear regression model using the Least Absolute Shrinkage and Selection Operator (LASSO).

Results

Peak BMD in men was higher than women, and the difference was more pronounced at the femoral neck (average difference: 0.123 g/cm²; 95% confidence interval [CI] 0.105-0.141 g/cm²) than at the lumbar spine (average difference 0.019 g/cm²; 95% CI, 0.005-0.036 g/cm²). Results of LASSO regression indicated that lean mass was the only predictor of BMD for either men or women. Each kilogram increase in lean mass was associated with ∼0.01 g/cm² increase in BMD. Lean mass alone explained 16% and 36% of variation in lumbar spine and femoral neck BMD, respectively.

Conclusions

Lean mass, not fat mass, is the main determinant of peak bone mineral density. This finding implies that good physical activity during adulthood can contribute to the maximization of peak bone mass during adulthood.

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http://hdl.handle.net/10453/146470