Nanosurfacing Ti alloy by weak alkalinity-activated solid-state dewetting (AAD) and its biointerfacial enhancement effect

Song, X; Liu, F; Qiu, C; Coy, E; Liu, H; Aperador, W; Załȩski, K; Li, JJ; Song, W; Lu, Z; Pan, H; Kong, L; Wang, G

Nanosurfacing Ti alloy by weak alkalinity-activated solid-state dewetting (AAD) and its biointerfacial enhancement effect

Song, X Liu, F Qiu, C Coy, E Liu, H Aperador, W Załȩski, K Li, JJ Song, W Lu, Z Pan, H Kong, L Wang, G

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Publisher:: ROYAL SOC CHEMISTRY
Publication Type:: Journal Article
Citation:: Materials Horizons, 2021, 8, (3), pp. 912-924
Issue Date:: 2021-03-01

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Field	Value	Language
dc.contributor.author	Song, X
dc.contributor.author	Liu, F
dc.contributor.author	Qiu, C
dc.contributor.author	Coy, E
dc.contributor.author	Liu, H
dc.contributor.author	Aperador, W
dc.contributor.author	Załȩski, K
dc.contributor.author	Li, JJ
dc.contributor.author	Song, W
dc.contributor.author	Lu, Z
dc.contributor.author	Pan, H
dc.contributor.author	Kong, L
dc.contributor.author	Wang, G
dc.date.accessioned	2021-08-20T07:58:53Z
dc.date.available	2021-08-20T07:58:53Z
dc.date.issued	2021-03-01
dc.identifier.citation	Materials Horizons, 2021, 8, (3), pp. 912-924
dc.identifier.issn	2051-6347
dc.identifier.issn	2051-6355
dc.identifier.uri	http://hdl.handle.net/10453/150190
dc.description.abstract	Nanoscale manipulation of material surfaces can create extraordinary properties, holding great potential for modulating the implant-bio interface for enhanced performance. In this study, a green, simple and biocompatible nanosurfacing approach based on weak alkalinity-activated solid-state dewetting (AAD) was for the first time developed to nano-manipulate the Ti6Al4V surface by atomic self-rearrangement. AAD treatment generated quasi-periodic titanium oxide nanopimples with high surface energy. The nanopimple-like nanostructures enhanced the osteogenic activity of osteoblasts, facilitated M2 polarization of macrophages, and modulated the cross-talk between osteoblasts and macrophages, which collectively led to significant strengthening of in vivo bone-implant interfacial bonding. In addition, the titanium oxide nanopimples strongly adhered to the Ti alloy, showing resistance to tribocorrosion damage. The results suggest strong nano-bio interfacial effects, which was not seen for the control Ti alloy processed through traditional thermal oxidation. Compared to other nanostructuring strategies, the AAD technique shows great potential to integrate high-performance, functionality, practicality and scalability for surface modification of medical implants.
dc.language	English
dc.publisher	ROYAL SOC CHEMISTRY
dc.relation	http://purl.org/au-research/grants/nhmrc/1120249
dc.relation.ispartof	Materials Horizons
dc.relation.isbasedon	10.1039/d0mh01837f
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0303 Macromolecular and Materials Chemistry, 0904 Chemical Engineering, 0912 Materials Engineering
dc.title	Nanosurfacing Ti alloy by weak alkalinity-activated solid-state dewetting (AAD) and its biointerfacial enhancement effect
dc.type	Journal Article
utslib.citation.volume	8
utslib.for	0303 Macromolecular and Materials Chemistry
utslib.for	0904 Chemical Engineering
utslib.for	0912 Materials Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2021-08-20T07:58:44Z
pubs.issue	3
pubs.publication-status	Published
pubs.volume	8
utslib.citation.issue	3

Abstract:

Nanoscale manipulation of material surfaces can create extraordinary properties, holding great potential for modulating the implant-bio interface for enhanced performance. In this study, a green, simple and biocompatible nanosurfacing approach based on weak alkalinity-activated solid-state dewetting (AAD) was for the first time developed to nano-manipulate the Ti6Al4V surface by atomic self-rearrangement. AAD treatment generated quasi-periodic titanium oxide nanopimples with high surface energy. The nanopimple-like nanostructures enhanced the osteogenic activity of osteoblasts, facilitated M2 polarization of macrophages, and modulated the cross-talk between osteoblasts and macrophages, which collectively led to significant strengthening of in vivo bone-implant interfacial bonding. In addition, the titanium oxide nanopimples strongly adhered to the Ti alloy, showing resistance to tribocorrosion damage. The results suggest strong nano-bio interfacial effects, which was not seen for the control Ti alloy processed through traditional thermal oxidation. Compared to other nanostructuring strategies, the AAD technique shows great potential to integrate high-performance, functionality, practicality and scalability for surface modification of medical implants.

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http://hdl.handle.net/10453/150190