Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells
- Publisher:
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Publication Type:
- Journal Article
- Citation:
- Biomedicine & Pharmacotherapy, 2021, 138, pp. 111425
- Issue Date:
- 2021-03-23
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Augustine, R | |
dc.contributor.author | Dan, P | |
dc.contributor.author | Hasan, A | |
dc.contributor.author | Khalaf, IM | |
dc.contributor.author | Prasad, P | |
dc.contributor.author | Ghosal, K | |
dc.contributor.author |
Gentile, C https://orcid.org/0000-0002-3689-4275 |
|
dc.contributor.author |
McClements, L https://orcid.org/0000-0002-4911-1014 |
|
dc.contributor.author | Maureira, P | |
dc.date.accessioned | 2022-01-12T08:17:35Z | |
dc.date.available | 2021-02-21 | |
dc.date.available | 2022-01-12T08:17:35Z | |
dc.date.issued | 2021-03-23 | |
dc.identifier.citation | Biomedicine & Pharmacotherapy, 2021, 138, pp. 111425 | |
dc.identifier.issn | 0753-3322 | |
dc.identifier.issn | 1950-6007 | |
dc.identifier.uri | http://hdl.handle.net/10453/153005 | |
dc.description.abstract | Cardiovascular disease is one of the leading causes of mortality worldwide. Cardiac tissue engineering strategies focusing on biomaterial scaffolds incorporating cells and growth factors are emerging as highly promising for cardiac repair and regeneration. The use of stem cells within cardiac microengineered tissue constructs present an inherent ability to differentiate into cell types of the human heart. Stem cells derived from various tissues including bone marrow, dental pulp, adipose tissue and umbilical cord can be used for this purpose. Approaches ranging from stem cell injections, stem cell spheroids, cell encapsulation in a suitable hydrogel, use of prefabricated scaffold and bioprinting technology are at the forefront in the field of cardiac tissue engineering. The stem cell microenvironment plays a key role in the maintenance of stemness and/or differentiation into cardiac specific lineages. This review provides a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue. A particular emphasis is given to the roles played by the extracellular matrix (ECM) in regulating the physiological response of stem cells within cardiac tissue engineering platforms. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | |
dc.relation.ispartof | Biomedicine & Pharmacotherapy | |
dc.relation.isbasedon | 10.1016/j.biopha.2021.111425 | |
dc.rights | This is an open access article under the CC BY license | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 1115 Pharmacology and Pharmaceutical Sciences | |
dc.subject.classification | Oncology & Carcinogenesis | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Cellular Microenvironment | |
dc.subject.mesh | Heart Diseases | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Mesenchymal Stem Cell Transplantation | |
dc.subject.mesh | Mesenchymal Stem Cells | |
dc.subject.mesh | Myocytes, Cardiac | |
dc.subject.mesh | Tissue Engineering | |
dc.subject.mesh | Transplantation, Autologous | |
dc.subject.mesh | Myocytes, Cardiac | |
dc.subject.mesh | Mesenchymal Stem Cells | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Heart Diseases | |
dc.subject.mesh | Mesenchymal Stem Cell Transplantation | |
dc.subject.mesh | Transplantation, Autologous | |
dc.subject.mesh | Tissue Engineering | |
dc.subject.mesh | Cellular Microenvironment | |
dc.title | Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells | |
dc.type | Journal Article | |
utslib.citation.volume | 138 | |
utslib.location.activity | France | |
utslib.for | 1115 Pharmacology and Pharmaceutical Sciences | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
pubs.organisational-group | /University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
pubs.organisational-group | /University of Technology Sydney/Centre for Health Technologies (CHT) | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2022-01-12T08:16:32Z | |
pubs.publication-status | Published | |
pubs.volume | 138 |
Abstract:
Cardiovascular disease is one of the leading causes of mortality worldwide. Cardiac tissue engineering strategies focusing on biomaterial scaffolds incorporating cells and growth factors are emerging as highly promising for cardiac repair and regeneration. The use of stem cells within cardiac microengineered tissue constructs present an inherent ability to differentiate into cell types of the human heart. Stem cells derived from various tissues including bone marrow, dental pulp, adipose tissue and umbilical cord can be used for this purpose. Approaches ranging from stem cell injections, stem cell spheroids, cell encapsulation in a suitable hydrogel, use of prefabricated scaffold and bioprinting technology are at the forefront in the field of cardiac tissue engineering. The stem cell microenvironment plays a key role in the maintenance of stemness and/or differentiation into cardiac specific lineages. This review provides a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue. A particular emphasis is given to the roles played by the extracellular matrix (ECM) in regulating the physiological response of stem cells within cardiac tissue engineering platforms.
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