Lung heterogeneity as a predictor for disease severity and response to therapy

Rutting, S; Chapman, DG; Farah, CS; Thamrin, C

Lung heterogeneity as a predictor for disease severity and response to therapy

Rutting, S Chapman, DG Farah, CS Thamrin, C

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Current Opinion in Physiology, 2021, 22, pp. 1-8
Issue Date:: 2021-08-01

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Field	Value	Language
dc.contributor.author	Rutting, S
dc.contributor.author	Chapman, DG
dc.contributor.author	Farah, CS
dc.contributor.author	Thamrin, C
dc.date.accessioned	2022-02-10T03:46:38Z
dc.date.available	2022-02-10T03:46:38Z
dc.date.issued	2021-08-01
dc.identifier.citation	Current Opinion in Physiology, 2021, 22, pp. 1-8
dc.identifier.issn	2468-8673
dc.identifier.issn	2468-8673
dc.identifier.uri	http://hdl.handle.net/10453/154372
dc.description.abstract	Heterogeneity is an intrinsic property of the lungs. Structurally, it is evident in the complex branching of the airways and the spatial distribution of tissue throughout the lung. Functionally, this translates to variation in the distribution of airway resistance and lung compliance, resulting in disparity in the filling and emptying rates between individual compartments, and consequently heterogeneous distribution of ventilation. Disease causes pathological alterations to structure and function, causing corresponding changes to heterogeneity, which can be measured via functional imaging, oscillometry or gas washout methods. This review describes key relevant concepts, and presents the most recent evidence for the significance of heterogeneity as a marker of disease severity and potential predictor of treatment or intervention response.
dc.language	en
dc.publisher	Elsevier
dc.relation.ispartof	Current Opinion in Physiology
dc.relation.isbasedon	10.1016/j.cophys.2021.05.009
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.title	Lung heterogeneity as a predictor for disease severity and response to therapy
dc.type	Journal Article
utslib.citation.volume	22
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
utslib.copyright.embargo	2022-08-31T00:00:00+1000Z
dc.date.updated	2022-02-10T03:46:37Z
pubs.publication-status	Published
pubs.volume	22

Abstract:

Heterogeneity is an intrinsic property of the lungs. Structurally, it is evident in the complex branching of the airways and the spatial distribution of tissue throughout the lung. Functionally, this translates to variation in the distribution of airway resistance and lung compliance, resulting in disparity in the filling and emptying rates between individual compartments, and consequently heterogeneous distribution of ventilation. Disease causes pathological alterations to structure and function, causing corresponding changes to heterogeneity, which can be measured via functional imaging, oscillometry or gas washout methods. This review describes key relevant concepts, and presents the most recent evidence for the significance of heterogeneity as a marker of disease severity and potential predictor of treatment or intervention response.

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http://hdl.handle.net/10453/154372