Effects of sample rheology on the equilibrium position of particles and cells within a spiral microfluidic channel

Raoufi, MA; Joushani, HAN; Razavi Bazaz, S; Ding, L; Asadnia, M; Ebrahimi Warkiani, M

Effects of sample rheology on the equilibrium position of particles and cells within a spiral microfluidic channel

Raoufi, MA Joushani, HAN Razavi Bazaz, S

Ding, L Asadnia, M Ebrahimi Warkiani, M

Permalink

Publisher:: Springer
Publication Type:: Journal Article
Citation:: Microfluidics and Nanofluidics, 2021, 25, (9), pp. 1-13
Issue Date:: 2021-09-01

Closed Access

	Filename	Description	Size
	Raoufi2021_Article_EffectsOfSampleRheologyOnTheEq.pdf		4.08 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Raoufi, MA
dc.contributor.author	Joushani, HAN
dc.contributor.author	Razavi Bazaz, S https://orcid.org/0000-0002-6419-3361
dc.contributor.author	Ding, L
dc.contributor.author	Asadnia, M
dc.contributor.author	Ebrahimi Warkiani, M https://orcid.org/0000-0002-4184-1944
dc.date.accessioned	2022-03-08T05:41:05Z
dc.date.available	2022-03-08T05:41:05Z
dc.date.issued	2021-09-01
dc.identifier.citation	Microfluidics and Nanofluidics, 2021, 25, (9), pp. 1-13
dc.identifier.issn	1613-4982
dc.identifier.issn	1613-4990
dc.identifier.uri	http://hdl.handle.net/10453/155064
dc.description.abstract	Elasto-inertial migration in non-Newtonian fluids is a rapidly growing field with tremendous potentials for manipulating micron to submicron particles. Previous research attempts were mainly carried out in straight channels due to the complexity of particle migration, solution tuning, and data analysis in elasto-inertial microfluidics. Consequently, the combined effects of Dean drag force and solution rheology on coupled Dean drag elasto-inertial focusing phenomena have not been carefully analyzed. This study delved thoroughly into the combined effects of solution rheology and Dean drag force on elasto-inertial focusing of particles and cells within a spiral microchannel. Polyethylene oxide (PEO) of 1MDa, 2MDa, and 4MDa molecular weights were used to prepare 250, 500, and 1000 ppm non-Newtonian solutions to investigate the focusing behavior of particles and cells over a wide range of flow rates and solution rheologies. Dean coupled elasto-inertial effects were systematically investigated to demonstrate its potentials for position-adjustable and size-tunable particle and cell focusing phenomenon. Various cells and microbeads with diameters ranging from 1 to 17 μm were employed to carefully study the equilibrium position, focusing band, and migration behavior under different elastic, inertial, and Dean conditions. Following the focusing, cell viability, morphology, and growth rate were evaluated which showed cells remained undamaged from viscosity, shear rate, and chemical properties of PEO solutions. We are of the opinion that the current study can provide scientists with a better understanding of focusing phenomena in viscoelastic fluids within spiral microfluidic channels.
dc.language	English
dc.publisher	Springer
dc.relation	http://purl.org/au-research/grants/arc/DP170103704
dc.relation	http://purl.org/au-research/grants/arc/DP180103003
dc.relation	http://purl.org/au-research/grants/nhmrc/1143377
dc.relation.ispartof	Microfluidics and Nanofluidics
dc.relation.isbasedon	10.1007/s10404-021-02475-2
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0913 Mechanical Engineering, 0915 Interdisciplinary Engineering, 1007 Nanotechnology
dc.subject.classification	Nanoscience & Nanotechnology
dc.title	Effects of sample rheology on the equilibrium position of particles and cells within a spiral microfluidic channel
dc.type	Journal Article
utslib.citation.volume	25
utslib.for	0913 Mechanical Engineering
utslib.for	0915 Interdisciplinary Engineering
utslib.for	1007 Nanotechnology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-03-08T05:41:03Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	25
utslib.citation.issue	9

Abstract:

Elasto-inertial migration in non-Newtonian fluids is a rapidly growing field with tremendous potentials for manipulating micron to submicron particles. Previous research attempts were mainly carried out in straight channels due to the complexity of particle migration, solution tuning, and data analysis in elasto-inertial microfluidics. Consequently, the combined effects of Dean drag force and solution rheology on coupled Dean drag elasto-inertial focusing phenomena have not been carefully analyzed. This study delved thoroughly into the combined effects of solution rheology and Dean drag force on elasto-inertial focusing of particles and cells within a spiral microchannel. Polyethylene oxide (PEO) of 1MDa, 2MDa, and 4MDa molecular weights were used to prepare 250, 500, and 1000 ppm non-Newtonian solutions to investigate the focusing behavior of particles and cells over a wide range of flow rates and solution rheologies. Dean coupled elasto-inertial effects were systematically investigated to demonstrate its potentials for position-adjustable and size-tunable particle and cell focusing phenomenon. Various cells and microbeads with diameters ranging from 1 to 17 μm were employed to carefully study the equilibrium position, focusing band, and migration behavior under different elastic, inertial, and Dean conditions. Following the focusing, cell viability, morphology, and growth rate were evaluated which showed cells remained undamaged from viscosity, shear rate, and chemical properties of PEO solutions. We are of the opinion that the current study can provide scientists with a better understanding of focusing phenomena in viscoelastic fluids within spiral microfluidic channels.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/155064