Microfluidics as efficient technology for the isolation and characterization of stem cells.

Aghlmandi, A; Nikshad, A; Safaralizadeh, R; Warkiani, ME; Aghebati-Maleki, L; Yousefi, M

Microfluidics as efficient technology for the isolation and characterization of stem cells.

Aghlmandi, A Nikshad, A Safaralizadeh, R Warkiani, ME Aghebati-Maleki, L Yousefi, M

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Publisher:: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Publication Type:: Journal Article
Citation:: EXCLI Journal, 2021, 20, pp. 426-443
Issue Date:: 2021

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Field	Value	Language
dc.contributor.author	Aghlmandi, A
dc.contributor.author	Nikshad, A
dc.contributor.author	Safaralizadeh, R
dc.contributor.author	Warkiani, ME
dc.contributor.author	Aghebati-Maleki, L
dc.contributor.author	Yousefi, M
dc.date.accessioned	2022-03-08T06:01:34Z
dc.date.available	2021-02-15
dc.date.available	2022-03-08T06:01:34Z
dc.date.issued	2021
dc.identifier.citation	EXCLI Journal, 2021, 20, pp. 426-443
dc.identifier.issn	1611-2156
dc.identifier.issn	1611-2156
dc.identifier.uri	http://hdl.handle.net/10453/155070
dc.description.abstract	The recent years have been passed with significant progressions in the utilization of microfluidic technologies for cellular investigations. The aim of microfluidics is to mimic small-scale body environment with features like optical transparency. Microfluidics can screen and monitor different cell types during culture and study cell function in response to stimuli in a fully controlled environment. No matter how the microfluidic environment is similar to in vivo environment, it is not possible to fully investigate stem cells behavior in response to stimuli during cell proliferation and differentiation. Researchers have used stem cells in different fields from fundamental researches to clinical applications. Many cells in the body possess particular functions, but stem cells do not have a specific task and can turn into almost any type of cells. Stem cells are undifferentiated cells with the ability of changing into specific cells that can be essential for the body. Researchers and physicians are interested in stem cells to use them in testing the function of the body's systems and solving their complications. This review discusses the recent advances in utilizing microfluidic techniques for the analysis of stem cells, and mentions the advantages and disadvantages of using microfluidic technology for stem cell research.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
dc.relation.ispartof	EXCLI Journal
dc.relation.isbasedon	10.17179/excli2020-3028
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Toxicology
dc.title	Microfluidics as efficient technology for the isolation and characterization of stem cells.
dc.type	Journal Article
utslib.citation.volume	20
utslib.location.activity	Germany
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-03-08T06:01:30Z
pubs.publication-status	Published
pubs.volume	20

Abstract:

The recent years have been passed with significant progressions in the utilization of microfluidic technologies for cellular investigations. The aim of microfluidics is to mimic small-scale body environment with features like optical transparency. Microfluidics can screen and monitor different cell types during culture and study cell function in response to stimuli in a fully controlled environment. No matter how the microfluidic environment is similar to in vivo environment, it is not possible to fully investigate stem cells behavior in response to stimuli during cell proliferation and differentiation. Researchers have used stem cells in different fields from fundamental researches to clinical applications. Many cells in the body possess particular functions, but stem cells do not have a specific task and can turn into almost any type of cells. Stem cells are undifferentiated cells with the ability of changing into specific cells that can be essential for the body. Researchers and physicians are interested in stem cells to use them in testing the function of the body's systems and solving their complications. This review discusses the recent advances in utilizing microfluidic techniques for the analysis of stem cells, and mentions the advantages and disadvantages of using microfluidic technology for stem cell research.

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http://hdl.handle.net/10453/155070