The mammary cellular hierarchy and breast cancer.

Oakes, SR; Gallego-Ortega, D; Ormandy, CJ

The mammary cellular hierarchy and breast cancer.

Oakes, SR Gallego-Ortega, D Ormandy, CJ

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Publisher:: SPRINGER BASEL AG
Publication Type:: Journal Article
Citation:: Cell Mol Life Sci, 2014, 71, (22), pp. 4301-4324
Issue Date:: 2014-11

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Field	Value	Language
dc.contributor.author	Oakes, SR
dc.contributor.author	Gallego-Ortega, D
dc.contributor.author	Ormandy, CJ
dc.date.accessioned	2022-04-13T12:34:58Z
dc.date.available	2014-06-23
dc.date.available	2022-04-13T12:34:58Z
dc.date.issued	2014-11
dc.identifier.citation	Cell Mol Life Sci, 2014, 71, (22), pp. 4301-4324
dc.identifier.issn	1420-682X
dc.identifier.issn	1420-9071
dc.identifier.uri	http://hdl.handle.net/10453/156226
dc.description.abstract	Advances in the study of hematopoietic cell maturation have paved the way to a deeper understanding the stem and progenitor cellular hierarchy in the mammary gland. The mammary epithelium, unlike the hematopoietic cellular hierarchy, sits in a complex niche where communication between epithelial cells and signals from the systemic hormonal milieu, as well as from extra-cellular matrix, influence cell fate decisions and contribute to tissue homeostasis. We review the discovery, definition and regulation of the mammary cellular hierarchy and we describe the development of the concepts that have guided our investigations. We outline recent advances in in vivo lineage tracing that is now challenging many of our assumptions regarding the behavior of mammary stem cells, and we show how understanding these cellular lineages has altered our view of breast cancer.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	SPRINGER BASEL AG
dc.relation.ispartof	Cell Mol Life Sci
dc.relation.isbasedon	10.1007/s00018-014-1674-4
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0601 Biochemistry and Cell Biology, 0606 Physiology, 1103 Clinical Sciences
dc.subject.classification	Biochemistry & Molecular Biology
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Cell Lineage
dc.subject.mesh	Female
dc.subject.mesh	Genetic Heterogeneity
dc.subject.mesh	Humans
dc.subject.mesh	Mammary Glands, Human
dc.subject.mesh	Neoplastic Stem Cells
dc.subject.mesh	Stem Cells
dc.subject.mesh	Mammary Glands, Human
dc.subject.mesh	Stem Cells
dc.subject.mesh	Humans
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Cell Lineage
dc.subject.mesh	Genetic Heterogeneity
dc.subject.mesh	Female
dc.subject.mesh	Neoplastic Stem Cells
dc.title	The mammary cellular hierarchy and breast cancer.
dc.type	Journal Article
utslib.citation.volume	71
utslib.location.activity	Switzerland
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	0606 Physiology
utslib.for	1103 Clinical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2022-04-13T12:34:54Z
pubs.issue	22
pubs.publication-status	Published
pubs.volume	71
utslib.citation.issue	22

Abstract:

Advances in the study of hematopoietic cell maturation have paved the way to a deeper understanding the stem and progenitor cellular hierarchy in the mammary gland. The mammary epithelium, unlike the hematopoietic cellular hierarchy, sits in a complex niche where communication between epithelial cells and signals from the systemic hormonal milieu, as well as from extra-cellular matrix, influence cell fate decisions and contribute to tissue homeostasis. We review the discovery, definition and regulation of the mammary cellular hierarchy and we describe the development of the concepts that have guided our investigations. We outline recent advances in in vivo lineage tracing that is now challenging many of our assumptions regarding the behavior of mammary stem cells, and we show how understanding these cellular lineages has altered our view of breast cancer.

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http://hdl.handle.net/10453/156226