Real versus simulated galactic cosmic radiation for investigating cancer risk in the hematopoietic system - are we comparing apples to apples?

Mehner, C; Krishnan, S; Chou, J; Freeman, ML; Freeman, WD; Patel, T; Turnbull, MT

Real versus simulated galactic cosmic radiation for investigating cancer risk in the hematopoietic system - are we comparing apples to apples?

Mehner, C Krishnan, S Chou, J

Freeman, ML Freeman, WD Patel, T Turnbull, MT

Permalink

Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Life Sci Space Res (Amst), 2021, 29, pp. 8-14
Issue Date:: 2021-05

Closed Access

	Filename	Description	Size
	1-s2.0-S2214552421000018-main.pdf	Published version	669.7 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Mehner, C
dc.contributor.author	Krishnan, S
dc.contributor.author	Chou, J https://orcid.org/0000-0002-7472-8016
dc.contributor.author	Freeman, ML
dc.contributor.author	Freeman, WD
dc.contributor.author	Patel, T
dc.contributor.author	Turnbull, MT
dc.date.accessioned	2022-05-22T22:35:39Z
dc.date.available	2021-01-14
dc.date.available	2022-05-22T22:35:39Z
dc.date.issued	2021-05
dc.identifier.citation	Life Sci Space Res (Amst), 2021, 29, pp. 8-14
dc.identifier.issn	2214-5524
dc.identifier.issn	2214-5532
dc.identifier.uri	http://hdl.handle.net/10453/157606
dc.description.abstract	Deep space exploration missions need strategies to mitigate the potentially harmful exposure to galactic cosmic radiation. This form of radiation can cause significant damage to biological systems and organisms, which include radiation-induced carcinogenesis in the hematopoietic system. Ongoing studies investigate these effects using cell- and animal-based studies in low earth orbit. The logistic challenges and costs involved with sending biological specimens to space have prompted the development of surrogate ground-based radiation experiments to study the mechanisms of biological injury and cancer risk. However, simulating galactic cosmic radiation has proven difficult and current studies are only partially succeeding at replicating the complexity of this radiation and its downstream injury pathways. Accurate simulation of chronic, low dose galactic radiation will improve our ability to test mitigation strategies such as drug development and improved shielding materials that could be crucial and essential for successful space exploration.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Life Sci Space Res (Amst)
dc.relation.isbasedon	10.1016/j.lssr.2021.01.001
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.mesh	Animals
dc.subject.mesh	Carcinogenesis
dc.subject.mesh	Cosmic Radiation
dc.subject.mesh	Hematopoietic System
dc.subject.mesh	Radiation Dosage
dc.subject.mesh	Space Flight
dc.subject.mesh	Hematopoietic System
dc.subject.mesh	Animals
dc.subject.mesh	Malus
dc.subject.mesh	Radiation Dosage
dc.subject.mesh	Cosmic Radiation
dc.subject.mesh	Space Flight
dc.subject.mesh	Carcinogenesis
dc.title	Real versus simulated galactic cosmic radiation for investigating cancer risk in the hematopoietic system - are we comparing apples to apples?
dc.type	Journal Article
utslib.citation.volume	29
utslib.location.activity	Netherlands
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	closed_access	*
dc.date.updated	2022-05-22T22:35:38Z
pubs.publication-status	Published
pubs.volume	29

Abstract:

Deep space exploration missions need strategies to mitigate the potentially harmful exposure to galactic cosmic radiation. This form of radiation can cause significant damage to biological systems and organisms, which include radiation-induced carcinogenesis in the hematopoietic system. Ongoing studies investigate these effects using cell- and animal-based studies in low earth orbit. The logistic challenges and costs involved with sending biological specimens to space have prompted the development of surrogate ground-based radiation experiments to study the mechanisms of biological injury and cancer risk. However, simulating galactic cosmic radiation has proven difficult and current studies are only partially succeeding at replicating the complexity of this radiation and its downstream injury pathways. Accurate simulation of chronic, low dose galactic radiation will improve our ability to test mitigation strategies such as drug development and improved shielding materials that could be crucial and essential for successful space exploration.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/157606